Q96A61 · TRI52_HUMAN

  • Protein
    E3 ubiquitin-protein ligase TRIM52
  • Gene
    TRIM52
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

E3 ubiquitin-protein ligase (PubMed:27667714).
Positively regulates the NF-kappa-B signaling pathway (PubMed:27667714, PubMed:28073078).
(Microbial infection) Exhibits antiviral activity against Japanese encephalitis virus (JEV). Ubiquitinates the viral non-structural protein 2 (NS2A) and targets it for proteasome-mediated degradation.

Miscellaneous

Arose via a partial duplication of the TRIM41 gene, followed by independent loss or pseudogenization of TRIM52 in multiple mammalian and primate lineages.

Catalytic activity

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.
    EC:2.3.2.27 (UniProtKB | ENZYME | Rhea)

Pathway

Protein modification; protein ubiquitination.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site227Zn2+ (UniProtKB | ChEBI)
Binding site230Zn2+ (UniProtKB | ChEBI)
Binding site249Zn2+ (UniProtKB | ChEBI)
Binding site255Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentcytosol
Cellular Componentnucleus
Molecular Functiontranscription coactivator activity
Molecular Functionubiquitin protein ligase activity
Molecular Functionzinc ion binding
Biological Processdefense response to virus
Biological Processpositive regulation of canonical NF-kappaB signal transduction
Biological Processpositive regulation of NF-kappaB transcription factor activity
Biological Processprotein autoubiquitination
Biological Processprotein ubiquitination

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    E3 ubiquitin-protein ligase TRIM52
  • EC number
  • Alternative names
    • RING finger protein 102
    • Tripartite motif-containing protein 52

Gene names

    • Name
      TRIM52
    • Synonyms
      RNF102

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q96A61
  • Secondary accessions
    • L0CQ38
    • Q59G66

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 316 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000562801-297E3 ubiquitin-protein ligase TRIM52

Post-translational modification

Autoubiquitinated (PubMed:27667714).
Polyubiquitinated (PubMed:20596523, PubMed:27667714).
Undergoes extremely rapid proteolytic degradation by the proteasome (PubMed:31133683).

Keywords

Proteomic databases

PTM databases

Expression

Induction

Up-regulated by Golgi stress-inducing agents such nigericin, trichostatin, tetoposide, campothecin and brefeldin A (PubMed:31133683).
Up-regulated by IL1B/interleukin-1 beta and TNFA/TNF-alpha (PubMed:28073078).

Gene expression databases

Organism-specific databases

Interaction

Subunit

(Microbial infection) Interacts with Japanese encephalitis virus non-structural protein 2 (NS2A); mediates the ubiquitination of NS2A, targeting it for proteasome-mediated degradation.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for zinc finger, region.

TypeIDPosition(s)Description
Zinc finger20-62RING-type; degenerate
Region72-167Important for rapid proteolytic degradation by the proteasome
Zinc finger222-263B box-type

Domain

The RING-type zinc finger domain is essential for its E3 ubiquitin-protein ligase activity, ability to positively regulate the NF-kappa-B signaling pathway and its antiviral activity.

Sequence similarities

Belongs to the TRIM/RBCC family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q96A61-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    297
  • Mass (Da)
    34,653
  • Last updated
    2001-12-01 v1
  • Checksum
    13381ED57BDCC6AB
MAGYATTPSPMQTLQEEAVCAICLDYFKDPVSISCGHNFCRGCVTQLWSKEDEEDQNEEEDEWEEEEDEEAVGAMDGWDGSIREVLYRGNADEELFQDQDDDELWLGDSGITNWDNVDYMWDEEEEEEEEDQDYYLGGLRPDLRIDVYREEEILEAYDEDEDEELYPDIHPPPSLPLPGQFTCPQCRKSFTRRSFRPNLQLANMVQIIRQMCPTPYRGNRSNDQGMCFKHQEALKLFCEVDKEAICVVCRESRSHKQHSVLPLEEVVQEYQEIKLETTLVGILQIEQESIHSKAYNQ

Q96A61-2

Computationally mapped potential isoform sequences

There are 6 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8I5KRY2A0A8I5KRY2_HUMANTRIM52272
A0A8I5KQM7A0A8I5KQM7_HUMANTRIM52287
A0A8I5KW90A0A8I5KW90_HUMANTRIM52277
A0A8I5KYD8A0A8I5KYD8_HUMANTRIM52285
A0A8I5KXP2A0A8I5KXP2_HUMANTRIM52307
A0A8I5KXQ2A0A8I5KXQ2_HUMANTRIM52331

Sequence caution

The sequence BAD92480.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.

Features

Showing features for sequence conflict, alternative sequence.

TypeIDPosition(s)Description
Sequence conflict130in Ref. 3; BAD92480
Alternative sequenceVSP_060452272-286in isoform 2
Alternative sequenceVSP_060453287-297in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JX896146
EMBL· GenBank· DDBJ
AGA17664.1
EMBL· GenBank· DDBJ
mRNA
AK054802
EMBL· GenBank· DDBJ
BAB70809.1
EMBL· GenBank· DDBJ
mRNA
AB209243
EMBL· GenBank· DDBJ
BAD92480.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AC008443
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471165
EMBL· GenBank· DDBJ
EAW53704.1
EMBL· GenBank· DDBJ
Genomic DNA
BC007372
EMBL· GenBank· DDBJ
AAH07372.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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