Q96689 · SPIKE_ADECR

Function

function

Forms spikes that protrude from each vertex of the icosahedral capsid. Interacts with host receptor to provide virion initial attachment to target cell. Fiber proteins are shed during virus entry, when virus is still at the cell surface (By similarity).

Miscellaneous

All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthost cell nucleus
Cellular Componentviral capsid
Biological Processadhesion receptor-mediated virion attachment to host cell
Biological Processcell adhesion
Biological Processsymbiont entry into host cell

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Fiber protein
  • Short names
    SPIKE
  • Alternative names
    • Protein IV

Gene names

    • ORF names
      L5

Organism names

Accessions

  • Primary accession
    Q96689

Subcellular Location

Virion
Host nucleus
Note: Anchored to the pentons, protrudes from the virion surface.

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002218061-543Fiber protein

Expression

Induction

Expressed in the late phase of the viral replicative cycle.

Keywords

Interaction

Subunit

Homotrimer. Interacts (via N-terminal tail region) with pentons (By similarity).

Structure

3D structure databases

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-36Disordered

Domain

The tail region anchors the fiber to penton base capsomers, whereas the shaft, built from several repeated motifs, allows the knob to protrude from the virion.

Sequence similarities

Belongs to the adenoviridae fiber family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    543
  • Mass (Da)
    56,974
  • Last updated
    1997-02-01 v1
  • Checksum
    36CC8094D3E22E26
MKRTRSALPANFDPVYPYDAPKPSTQPPFFNDRKGLTESSPGTLAVNISPPLTFSNLGAIKLSTGAGLILKEGKLEANIGPGLTTNQEGQITVEKDSDGLTFTSPLHKIENTVSLSIGEGLEDESGTLKVNFPSPPPPLLFSPPLAEAGGTVSLPLQESMQVTEGKLGVKPTTYSPPLQKTDQQVSLRVGPGLTVLNGQLQAVQPPATTYKEPLLETENSVSLKVGAGLAVQDGALVATPPNVTFSAPLEKNGNAVSVRVGAGLSIQGNALVATTSPTLTFAYPLIKNNNHITLSAGSGLRVSGGSLTVATGPGLSHINGTIAAVIGAGLKFENNAILAKLGNGLTIRDGAIEAVAPQPSFTPVTLWTGPDPNVNTSINGTPVIRSFISLTRDSNLVTVNASFTGEGSYQSVSPTQSQFSLILEFNQFGQLMSTGNLNSTTTWGEKPWGNNTVQVQPSHTWKLCMPNREVYSTPAATLTSCGLNSIAHDGAPNRSIDCMLIINKLAGAATYTLTFRFLNFNKLSSSTVFKTDVLTFTYVGENQ

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
Y07760
EMBL· GenBank· DDBJ
CAA69045.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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