Q962P8 · TBA6_NAEPR

Function

function

Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site, active site.

145250100150200250300350400450
Type
IDPosition(s)Description
Binding site11GTP (UniProtKB | ChEBI)
Binding site69GTP (UniProtKB | ChEBI)
Binding site69Mg2+ (UniProtKB | ChEBI)
Binding site138GTP (UniProtKB | ChEBI)
Binding site142GTP (UniProtKB | ChEBI)
Binding site143GTP (UniProtKB | ChEBI)
Binding site177GTP (UniProtKB | ChEBI)
Binding site204GTP (UniProtKB | ChEBI)
Binding site226GTP (UniProtKB | ChEBI)
Active site252

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentmicrotubule
Cellular Componentspindle
Molecular FunctionGTP binding
Molecular Functionhydrolase activity
Molecular Functionmetal ion binding
Molecular Functionstructural constituent of cytoskeleton
Biological Processmicrotubule cytoskeleton organization
Biological Processmitotic cell cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Tubulin alpha-6 chain
  • EC number

Gene names

    • Name
      TUBA6

Organism names

Accessions

  • Primary accession
    Q962P8

Subcellular Location

Note: Present in the nuclei and mitotic spindle-fibers but absent in flagellar axonemes or cytoskeletal microtubules.

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000481961-452Tubulin alpha-6 chain

Expression

Developmental stage

Expressed in actively growing cells and repressed quickly when these cells were induced to differentiate.

Interaction

Subunit

Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.

Structure

Family & Domains

Sequence similarities

Belongs to the tubulin family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    452
  • Mass (Da)
    50,470
  • Last updated
    2001-12-01 v1
  • MD5 Checksum
    3CE98F19B8E249FF31FD2A38074B7077
MREIINIHIGQAGIQAGEQVWSLMCAEHGINQDGTRNSTSANGNSDCSVLFSEGSRGKYVPRNLMVDLEPSVVDSVRNSSYKELYHPAQMITGREDAANNFARGHYTVGKDMLDVTVDRLRKIADNCTSLQGFQIFHSVGGGTGSGFASLLVERLSVEFPKKCKLSYTVYPSPQLATSVVEPYNSVLSTHSLLEHNDISVVLDNQAIYDICKQRLKIERANYRNLNHVISQTVSAITCSLRFSGSLNVDMNEYQTNLVPYPRIHFMLSSLAPMISRQENYYHENNVAELTSSVFEADNMMAKCNPRDGKYIASCLMYRGDVVNKEVTDAVKNVKSKANIQFVDWSPCAFKIGVNSQKPTVLPDSEFAQVERSCAMISNNTAISQVFERMNDKFDLLYAKRAYVHHFVSEGMEEGEFAEAREDLAALEKDYTELASNSVNEEDSMLDEGETLN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF401640
EMBL· GenBank· DDBJ
AAK84065.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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