Q960M4 · Q960M4_DROME

Function

function

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.

Catalytic activity

Features

Showing features for active site.

119020406080100120140160180
TypeIDPosition(s)Description
Active site79Cysteine sulfenic acid (-SOH) intermediate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentcytosol
Cellular Componentmitochondrion
Cellular Componentnucleus
Cellular Componentperoxisomal matrix
Cellular Componentperoxisome
Molecular Functionthioredoxin peroxidase activity
Molecular Functionthioredoxin-dependent peroxiredoxin activity
Biological Processcell redox homeostasis
Biological Processcellular response to oxidative stress
Biological Processdetermination of adult lifespan
Biological Processhydrogen peroxide catabolic process
Biological Processnegative regulation of apoptotic process
Biological Processnegative regulation of innate immune response
Biological Processresponse to oxidative stress

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Peroxiredoxin-5
  • EC number

Gene names

    • Name
      Prx5
    • Synonyms
      CG 32920
      , CG 7217
      , CG3292
      , CG32920
      , CG7215-RA
      , Dmel\CG7217
      , dPrx5
      , dprx5
      , dPrxV
      , prx5
    • ORF names
      CG7217
      , Dmel_CG7217

Organism names

  • Taxonomic identifier
  • Strain
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    Q960M4

Proteomes

Organism-specific databases

PTM/Processing

Proteomic databases

Expression

Gene expression databases

    • FBgn0038570Expressed in insect adult head and 39 other cell types or tissues

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain35-190Thioredoxin

Sequence similarities

Belongs to the peroxiredoxin family. Prx5 subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    190
  • Mass (Da)
    19,896
  • Last updated
    2001-12-01 v1
  • Checksum
    F80D732AD511D25D
MRVLSCKFLGRVVNSALPQQIISLRSLSKTSAAMVKVGDSLPSVDLFEDSPANKINTGDLVNGKKVIIFGVPGAFTPGCSKTHLPGYVSSADELKSKQGVDEIVCVSVNDPFVMSAWGKEHGAAGKVRLLADPAGGFTKALDVTIDLPPLGGVRSKRYSLVVENGKVTELNVEPDGTGLSCSLANNIGKK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE014297
EMBL· GenBank· DDBJ
AAF55497.2
EMBL· GenBank· DDBJ
Genomic DNA
AY051983
EMBL· GenBank· DDBJ
AAK93407.1
EMBL· GenBank· DDBJ
mRNA
BT003526
EMBL· GenBank· DDBJ
AAO39530.1
EMBL· GenBank· DDBJ
mRNA
AE014297
EMBL· GenBank· DDBJ
AAO41575.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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