Q95YM9 · FGFR_HALRO

Function

function

Receptor for basic fibroblast growth factor.

Catalytic activity

Features

Showing features for binding site, active site.

1763100200300400500600700
TypeIDPosition(s)Description
Binding site388-396ATP (UniProtKB | ChEBI)
Binding site417ATP (UniProtKB | ChEBI)
Active site537Proton acceptor

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmembrane
Cellular Componentreceptor complex
Molecular FunctionATP binding
Molecular Functionfibroblast growth factor binding
Molecular Functionfibroblast growth factor receptor activity
Biological Processpositive regulation of cell population proliferation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Fibroblast growth factor receptor
  • EC number
  • Short names
    HrFGFR

Gene names

    • Name
      FGFR

Organism names

Accessions

  • Primary accession
    Q95YM9

Subcellular Location

Membrane
; Single-pass membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain28-291Extracellular
Transmembrane292-312Helical
Topological domain313-763Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation, modified residue.

TypeIDPosition(s)Description
Signal1-27
ChainPRO_000024921528-763Fibroblast growth factor receptor
Disulfide bond98↔148
Glycosylation158N-linked (GlcNAc...) asparagine
Glycosylation182N-linked (GlcNAc...) asparagine
Disulfide bond195↔254
Glycosylation220N-linked (GlcNAc...) asparagine
Glycosylation230N-linked (GlcNAc...) asparagine
Glycosylation243N-linked (GlcNAc...) asparagine
Glycosylation288N-linked (GlcNAc...) asparagine
Modified residue568Phosphotyrosine; by autocatalysis

Keywords

PTM databases

Expression

Developmental stage

Maternally expressed transcript was ubiquitously distributed in fertilized eggs and in early embryos. Zygotic expression became evident by the neurula stage and transcripts were detected in epidermal cells of the posterior half of embryos.

Structure

Family & Domains

Features

Showing features for region, domain, compositional bias.

TypeIDPosition(s)Description
Region34-74Disordered
Domain73-164Ig-like C2-type 1
Domain173-270Ig-like C2-type 2
Domain382-672Protein kinase
Compositional bias691-709Acidic residues
Region691-742Disordered
Compositional bias717-742Polar residues

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    763
  • Mass (Da)
    86,741
  • Last updated
    2001-12-01 v1
  • Checksum
    A34C1871DB796950
MKEFEVKVASTAFVLVLFSLTINQILASETSTKFRSPVPAPTVPDWNHLPNEGNEENVVSAPKQDGASGGQKPYWTKREKMMKRLHAEPAGNTVRFRCAVDGNPKPQVLWYKNDLIVQKNDRVGGYKYRNQVLILESVVLSDKGNYMCVARNEYGSINHTYQLDVQERSASKPILAEGLPQNKSAYIGDDVTFKCKVYSDAHPHIQWLKSINNHNNAAPNYTVLKAAGVNTTDLDMEVLILKNVSFEEAGEYTCLAGNSIGISHQSAWLSVLPVPPPTTDTITKGIPNETNIIIYVMCGVLVILFGLAVVLVLYYHCYNGKDPPMLVRIENPDNIPPMTKIEHPTMLFGNTQAWQRMCMPMQEPFEFNIQLDLQWELQREDITLVERLDEGFFGQVFKADLVTCNNTRKEKMVCAVKMLKGNRNEKDVLDLLTEMDQMKRVGKHKNIINLLGVCTQNGPLWLVIEYAAQGNLRDYLRRNRPQNTLCNLVLPSEGRNPDDELPVPHGDTLTQKDIVSFAFQVARGLEFLAQKKCIHRDLAARNVLVTEELVMKIADFGLARDIRSCDYYRKHTRGHLPYKWMALEAMSDNIFTHATDVWSFGVLLWEIFSLAGSPYPGIKTHELVKFLRSGERLDKPQYASQEMYRLMRDCWEEDPSKRPNFRTLVEDLDRMLAESSTEVYIDFAAGCEAEYSESSEDESESQNSDEEDDDSVFERMRQIDSLSNGNIPFNEEDSSNSDPYVAPLLQNEENVLQNEHARLRSEA

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias691-709Acidic residues
Compositional bias717-742Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB046873
EMBL· GenBank· DDBJ
BAB59007.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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