Q95YM9 · FGFR_HALRO
- ProteinFibroblast growth factor receptor
- GeneFGFR
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids763 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Receptor for basic fibroblast growth factor.
Catalytic activity
- ATP + L-tyrosyl-[protein] = ADP + H+ + O-phospho-L-tyrosyl-[protein]
Features
Showing features for binding site, active site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Cellular Component | receptor complex | |
Molecular Function | ATP binding | |
Molecular Function | fibroblast growth factor binding | |
Molecular Function | fibroblast growth factor receptor activity | |
Biological Process | positive regulation of cell population proliferation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameFibroblast growth factor receptor
- EC number
- Short namesHrFGFR
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Tunicata > Ascidiacea > Stolidobranchia > Pyuridae > Halocynthia
Accessions
- Primary accessionQ95YM9
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 28-291 | Extracellular | ||||
Sequence: SETSTKFRSPVPAPTVPDWNHLPNEGNEENVVSAPKQDGASGGQKPYWTKREKMMKRLHAEPAGNTVRFRCAVDGNPKPQVLWYKNDLIVQKNDRVGGYKYRNQVLILESVVLSDKGNYMCVARNEYGSINHTYQLDVQERSASKPILAEGLPQNKSAYIGDDVTFKCKVYSDAHPHIQWLKSINNHNNAAPNYTVLKAAGVNTTDLDMEVLILKNVSFEEAGEYTCLAGNSIGISHQSAWLSVLPVPPPTTDTITKGIPNETN | ||||||
Transmembrane | 292-312 | Helical | ||||
Sequence: IIIYVMCGVLVILFGLAVVLV | ||||||
Topological domain | 313-763 | Cytoplasmic | ||||
Sequence: LYYHCYNGKDPPMLVRIENPDNIPPMTKIEHPTMLFGNTQAWQRMCMPMQEPFEFNIQLDLQWELQREDITLVERLDEGFFGQVFKADLVTCNNTRKEKMVCAVKMLKGNRNEKDVLDLLTEMDQMKRVGKHKNIINLLGVCTQNGPLWLVIEYAAQGNLRDYLRRNRPQNTLCNLVLPSEGRNPDDELPVPHGDTLTQKDIVSFAFQVARGLEFLAQKKCIHRDLAARNVLVTEELVMKIADFGLARDIRSCDYYRKHTRGHLPYKWMALEAMSDNIFTHATDVWSFGVLLWEIFSLAGSPYPGIKTHELVKFLRSGERLDKPQYASQEMYRLMRDCWEEDPSKRPNFRTLVEDLDRMLAESSTEVYIDFAAGCEAEYSESSEDESESQNSDEEDDDSVFERMRQIDSLSNGNIPFNEEDSSNSDPYVAPLLQNEENVLQNEHARLRSEA |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond, glycosylation, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-27 | |||||
Sequence: MKEFEVKVASTAFVLVLFSLTINQILA | ||||||
Chain | PRO_0000249215 | 28-763 | Fibroblast growth factor receptor | |||
Sequence: SETSTKFRSPVPAPTVPDWNHLPNEGNEENVVSAPKQDGASGGQKPYWTKREKMMKRLHAEPAGNTVRFRCAVDGNPKPQVLWYKNDLIVQKNDRVGGYKYRNQVLILESVVLSDKGNYMCVARNEYGSINHTYQLDVQERSASKPILAEGLPQNKSAYIGDDVTFKCKVYSDAHPHIQWLKSINNHNNAAPNYTVLKAAGVNTTDLDMEVLILKNVSFEEAGEYTCLAGNSIGISHQSAWLSVLPVPPPTTDTITKGIPNETNIIIYVMCGVLVILFGLAVVLVLYYHCYNGKDPPMLVRIENPDNIPPMTKIEHPTMLFGNTQAWQRMCMPMQEPFEFNIQLDLQWELQREDITLVERLDEGFFGQVFKADLVTCNNTRKEKMVCAVKMLKGNRNEKDVLDLLTEMDQMKRVGKHKNIINLLGVCTQNGPLWLVIEYAAQGNLRDYLRRNRPQNTLCNLVLPSEGRNPDDELPVPHGDTLTQKDIVSFAFQVARGLEFLAQKKCIHRDLAARNVLVTEELVMKIADFGLARDIRSCDYYRKHTRGHLPYKWMALEAMSDNIFTHATDVWSFGVLLWEIFSLAGSPYPGIKTHELVKFLRSGERLDKPQYASQEMYRLMRDCWEEDPSKRPNFRTLVEDLDRMLAESSTEVYIDFAAGCEAEYSESSEDESESQNSDEEDDDSVFERMRQIDSLSNGNIPFNEEDSSNSDPYVAPLLQNEENVLQNEHARLRSEA | ||||||
Disulfide bond | 98↔148 | |||||
Sequence: CAVDGNPKPQVLWYKNDLIVQKNDRVGGYKYRNQVLILESVVLSDKGNYMC | ||||||
Glycosylation | 158 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 182 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 195↔254 | |||||
Sequence: CKVYSDAHPHIQWLKSINNHNNAAPNYTVLKAAGVNTTDLDMEVLILKNVSFEEAGEYTC | ||||||
Glycosylation | 220 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 230 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 243 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 288 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Modified residue | 568 | Phosphotyrosine; by autocatalysis | ||||
Sequence: Y |
Keywords
- PTM
PTM databases
Expression
Developmental stage
Maternally expressed transcript was ubiquitously distributed in fertilized eggs and in early embryos. Zygotic expression became evident by the neurula stage and transcripts were detected in epidermal cells of the posterior half of embryos.
Structure
Family & Domains
Features
Showing features for region, domain, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 34-74 | Disordered | ||||
Sequence: FRSPVPAPTVPDWNHLPNEGNEENVVSAPKQDGASGGQKPY | ||||||
Domain | 73-164 | Ig-like C2-type 1 | ||||
Sequence: PYWTKREKMMKRLHAEPAGNTVRFRCAVDGNPKPQVLWYKNDLIVQKNDRVGGYKYRNQVLILESVVLSDKGNYMCVARNEYGSINHTYQLD | ||||||
Domain | 173-270 | Ig-like C2-type 2 | ||||
Sequence: PILAEGLPQNKSAYIGDDVTFKCKVYSDAHPHIQWLKSINNHNNAAPNYTVLKAAGVNTTDLDMEVLILKNVSFEEAGEYTCLAGNSIGISHQSAWLS | ||||||
Domain | 382-672 | Protein kinase | ||||
Sequence: ITLVERLDEGFFGQVFKADLVTCNNTRKEKMVCAVKMLKGNRNEKDVLDLLTEMDQMKRVGKHKNIINLLGVCTQNGPLWLVIEYAAQGNLRDYLRRNRPQNTLCNLVLPSEGRNPDDELPVPHGDTLTQKDIVSFAFQVARGLEFLAQKKCIHRDLAARNVLVTEELVMKIADFGLARDIRSCDYYRKHTRGHLPYKWMALEAMSDNIFTHATDVWSFGVLLWEIFSLAGSPYPGIKTHELVKFLRSGERLDKPQYASQEMYRLMRDCWEEDPSKRPNFRTLVEDLDRML | ||||||
Compositional bias | 691-709 | Acidic residues | ||||
Sequence: YSESSEDESESQNSDEEDD | ||||||
Region | 691-742 | Disordered | ||||
Sequence: YSESSEDESESQNSDEEDDDSVFERMRQIDSLSNGNIPFNEEDSSNSDPYVA | ||||||
Compositional bias | 717-742 | Polar residues | ||||
Sequence: RQIDSLSNGNIPFNEEDSSNSDPYVA |
Sequence similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length763
- Mass (Da)86,741
- Last updated2001-12-01 v1
- ChecksumA34C1871DB796950
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 691-709 | Acidic residues | ||||
Sequence: YSESSEDESESQNSDEEDD | ||||||
Compositional bias | 717-742 | Polar residues | ||||
Sequence: RQIDSLSNGNIPFNEEDSSNSDPYVA |