Q95WY7 · SP14_IXOSC

Function

function

Salivary anticoagulant protein that facilitates blood feeding of adult ticks on vertebrate species (PubMed:12421422, PubMed:14745044, PubMed:34118237).
Inhibits host coagulation factor Xa (F10) (PubMed:12421422).
Blocks the assembly and/or early activity of the prothrombinase complex (Xa-Va/F10-F5) (PubMed:34118237).
Inhibits the lectin pathway of complement system activation in the host (PubMed:34118237).

Caution

In one study, the protein was described as an inhibitor of host coagulation factor Xa (F10) (PubMed:11574922).
In another report, anticoagulant properties of the protein were attributed to its C-terminus (amino acids 91-125), but no significant effects on factor Xa amidolytic activity were observed using this truncated construct; instead, it was suggested that the peptide blocks the assembly and/or activity of the prothrombinase complex (Xa-Va/F10-F5) (PubMed:34118237).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Molecular Functiontoxin activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Anticoagulant salivary protein 14
  • Alternative names
    • 14 kDa salivary gland protein

Gene names

    • Name
      Salp14

Organism names

Accessions

  • Primary accession
    Q95WY7

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

RNAi-mediated knockdown results in impaired feeding of adult ticks, observed as decline in the engorgement weights (PubMed:14745044).
Decreased ability of salivary gland extracts from adult ticks to inhibit host clotting in vitro; when silenced together with Salp9Pac (PubMed:14745044).
No significant effects on the ability of nymphs to feed (PubMed:17038693).
(Microbial infection) RNAi-mediated knockdown has no significant effects on acquisition of Borrelia burgdorferi by nymphs 72 hours after feeding.
(Microbial infection) RNAi-mediated knockdown has no significant effects on acquisition of Anaplasma phagocytophilum by nymphs 72 hours after feeding.

PTM/Processing

Features

Showing features for signal, chain, glycosylation.

TypeIDPosition(s)Description
Signal1-21
ChainPRO_500432224122-125Anticoagulant salivary protein 14
Glycosylation26N-linked (GlcNAc...) asparagine
Glycosylation81N-linked (GlcNAc...) asparagine
Glycosylation87N-linked (GlcNAc...) asparagine

Keywords

Expression

Tissue specificity

Salivary gland (at protein level) (PubMed:14745044, PubMed:17038693).
Saliva (at protein level) (PubMed:12421422).

Induction

Induced in salivary glands by blood feeding.

Family & Domains

Features

Showing features for compositional bias, region.

TypeIDPosition(s)Description
Compositional bias75-90Polar residues
Region75-125Disordered
Region91-125Responsible for anticoagulant activity
Compositional bias101-118Basic residues

Sequence similarities

Belongs to the salp14 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    125
  • Mass (Da)
    13,979
  • Last updated
    2001-12-01 v1
  • Checksum
    C3D02F586E2AE07B
MGLTGTMLVLVSLAFFGSAAAHNCQNGTRPASEQDREGCDYYCWNAETKSWDQFFFGNGEKCFYNSGDHGTCQNGECHLTNNSGGPNETDDYTPAPTEKPKQKKKKTKKTKKPKRKSKKDQEKNL

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias75-90Polar residues
Compositional bias101-118Basic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF209921
EMBL· GenBank· DDBJ
AAK97824.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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