Q95QD7 · LIN54_CAEEL

  • Protein
    Protein lin-54
  • Gene
    lin-54
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Synthetic multivulva class B (synMuvB) protein. SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that repress transcription.

Features

Showing features for binding site, site.

143550100150200250300350400
TypeIDPosition(s)Description
Binding site177Zn2+ 1 (UniProtKB | ChEBI)
Binding site177Zn2+ 2 (UniProtKB | ChEBI)
Binding site179Zn2+ 1 (UniProtKB | ChEBI)
Binding site184Zn2+ 1 (UniProtKB | ChEBI)
Binding site184Zn2+ 3 (UniProtKB | ChEBI)
Site188Critical for interaction with target DNA
Binding site189Zn2+ 1 (UniProtKB | ChEBI)
Binding site191Zn2+ 2 (UniProtKB | ChEBI)
Binding site198Zn2+ 2 (UniProtKB | ChEBI)
Binding site198Zn2+ 3 (UniProtKB | ChEBI)
Binding site201Zn2+ 2 (UniProtKB | ChEBI)
Binding site203Zn2+ 3 (UniProtKB | ChEBI)
Binding site206Zn2+ 3 (UniProtKB | ChEBI)
Site226Interaction with DNA
Binding site253Zn2+ 4 (UniProtKB | ChEBI)
Binding site253Zn2+ 5 (UniProtKB | ChEBI)
Binding site255Zn2+ 4 (UniProtKB | ChEBI)
Binding site260Zn2+ 4 (UniProtKB | ChEBI)
Binding site260Zn2+ 6 (UniProtKB | ChEBI)
Site264Critical for interaction with target DNA
Binding site265Zn2+ 4 (UniProtKB | ChEBI)
Binding site267Zn2+ 5 (UniProtKB | ChEBI)
Binding site274Zn2+ 5 (UniProtKB | ChEBI)
Binding site274Zn2+ 6 (UniProtKB | ChEBI)
Binding site278Zn2+ 5 (UniProtKB | ChEBI)
Binding site280Zn2+ 6 (UniProtKB | ChEBI)
Binding site283Zn2+ 6 (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentautosome
Cellular Componentcondensed nuclear chromosome
Cellular ComponentDRM complex
Cellular Componentnucleus
Molecular Functionmetal ion binding
Molecular FunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding
Biological Processnegative regulation of vulval development
Biological Processregulation of DNA-templated transcription
Biological Processregulation of transcription by RNA polymerase II

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein lin-54
  • Alternative names
    • Abnormal cell lineage protein 54

Gene names

    • Name
      lin-54
    • ORF names
      JC8.6

Organism names

  • Taxonomic identifier
  • Strain
    • Bristol N2
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis

Accessions

  • Primary accession
    Q95QD7
  • Secondary accessions
    • O62295

Proteomes

Organism-specific databases

Subcellular Location

Nucleus
Chromosome
Note: Localizes to condensed chromosomes during the diakinesis phase of meiosis.

Keywords

Phenotypes & Variants

Disruption phenotype

Decreased protein levels of DRM complex components including lin-9 and lin-52 (PubMed:17075059).
Double knockout with the programmed cell death regulator mcd-1 results in 100% lethality during the L1 stage of larval development (PubMed:17237514).
RNAi-mediated knockdown in a ced-1 mutant background results in reduced somatic cell apoptosis (PubMed:27650246).

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003413951-435Protein lin-54

Proteomic databases

Expression

Developmental stage

Widely expressed. Present in most cells from the embryo through the adulthood.

Gene expression databases

Interaction

Subunit

Component of the DRM complex, at least composed of lin-9, lin-35, lin-37, lin-52, lin-53, lin-54- dpl-1 and efl-1.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q95QD7lin-37 Q234826EBI-6762766, EBI-324325

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region73-136Disordered
Compositional bias98-128Polar residues
Domain173-288CRC
Region175-188DNA-binding
Region235-250Linker
Region253-266DNA-binding
Region415-435Disordered

Domain

The CRC domain mediates DNA-binding. It contains two CXC subdomains (joined by a flexible linker) which are both required for efficient association with target DNA. Each CXC subdomain coordinates three Zn2+ ions.

Sequence similarities

Belongs to the lin-54 family.

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q95QD7-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    435
  • Mass (Da)
    49,109
  • Last updated
    2001-12-01 v1
  • Checksum
    7629A5C749D25A5D
MNQGEIVYQDDDDYYDESEIYDNYEEGAEFIEVNGQLVPHNPNLQAQQNRPGTSSMIQQHNRSMEVNQGLVKDEPIDTSSHRVYVPPPRPVQRKLFQPGPSTPGSSQYTVRNLSNLSGSPSMYDRQPASLPRTVQPMGLEMGNSEQRKVYIDMKDHVSHIRLKTKKKVFAPGQRKPCNCTKSQCLKLYCDCFANGEFCRDCNCKDCHNNIEYDSQRSKAIRQSLERNPNAFKPKIGIARGGITDIERLHQKGCHCKKSGCLKNYCECYEAKVPCTDRCKCKGCQNTETYRMTRYKNSGGAVSNTNALMSLTNASSTATPDSGPGSVVTDEHGDDYEDMLLSHKPKVEMDPRRFPWYYMTDEVVEAATMCMVAQAEEALNYEKVQTEDEKLINMEKLVLREFGRCLEQMITNTTELTQDLDAAPTDDIPGPSTSTS

Q95QD7-2

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A486WX88A0A486WX88_CAEELlin-54432
A0A486WWG3A0A486WWG3_CAEELlin-54432

Features

Showing features for alternative sequence, compositional bias.

TypeIDPosition(s)Description
Alternative sequenceVSP_03428043-45in isoform b
Alternative sequenceVSP_03428195-97in isoform b
Compositional bias98-128Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
Z82274
EMBL· GenBank· DDBJ
CAB05229.1
EMBL· GenBank· DDBJ
Genomic DNA
Z82274
EMBL· GenBank· DDBJ
CAB05228.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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