Q95Q34 · RIOK2_CAEEL
- ProteinSerine/threonine-protein kinase RIO2
- Generiok-2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids529 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Required for larval development.
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Cofactor
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | nucleus | |
Cellular Component | preribosome, small subunit precursor | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | protein kinase activity | |
Molecular Function | protein serine kinase activity | |
Molecular Function | protein serine/threonine kinase activity | |
Biological Process | maturation of SSU-rRNA | |
Biological Process | nematode larval development |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSerine/threonine-protein kinase RIO2
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis
Accessions
- Primary accessionQ95Q34
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Phenotypes & Variants
Disruption phenotype
RNAi-mediated knockdown causes early larval arrest. In adults, results in no obvious phenotype.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000434606 | 1-529 | Serine/threonine-protein kinase RIO2 | |||
Sequence: MGRMNVSMMRYLEGDHFRVLIAVEMGMKNHEVVPLALVSAIAGIHRGGVARTLNDLCKHSLVAFERSKKFDGYRLTIRGYDYLALRALCSREVVGSVGNQIGIGKESDVYVGGDPELNDLCLKFHRLGRTSFRKIKEKRDYHKKRKSASWLYLSRLAAAKEFAFLKALQERGFPVPKAVDVCRHLVVMQLVVGQTLCNVTHVEDAGALYDRLMALIVKMARHGVIHGDFNEFNLIMLEDERIVMIDFPQMVSIDHPNAEYYFDRDVTCVRTFFKRKFDYESEDWPKFDEVERKGNMDVLLEASGFTKKMALDLNKAYDEGDFLAHCEQELRNRQEEDLGEDEDDSDDSKSMEDIQEEPEDLEKDHEELQAQENTVKQQKIVLSQTTRFTDWLSDATNQLEAVDLDALKSEEGYKDIELPPEDFKRPADSENDDENDEDEEEGEEEDADGHVAVEEQVAKVVKKKRVPSGARSVASSAATFTAEDVKRRLALDRKRNKEKIRLKVKGKQSAVGRNRKDNKDVIAEYAGWI |
Proteomic databases
Expression
Tissue specificity
Expressed in pharynx (metacorpus and posterior bulbus). Expression is restricted to adult stage.
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 97-273 | Protein kinase | ||||
Sequence: VGNQIGIGKESDVYVGGDPELNDLCLKFHRLGRTSFRKIKEKRDYHKKRKSASWLYLSRLAAAKEFAFLKALQERGFPVPKAVDVCRHLVVMQLVVGQTLCNVTHVEDAGALYDRLMALIVKMARHGVIHGDFNEFNLIMLEDERIVMIDFPQMVSIDHPNAEYYFDRDVTCVRTFF | ||||||
Region | 331-366 | Disordered | ||||
Sequence: RNRQEEDLGEDEDDSDDSKSMEDIQEEPEDLEKDHE | ||||||
Compositional bias | 336-363 | Acidic residues | ||||
Sequence: EDLGEDEDDSDDSKSMEDIQEEPEDLEK | ||||||
Compositional bias | 411-430 | Basic and acidic residues | ||||
Sequence: EGYKDIELPPEDFKRPADSE | ||||||
Region | 411-452 | Disordered | ||||
Sequence: EGYKDIELPPEDFKRPADSENDDENDEDEEEGEEEDADGHVA | ||||||
Compositional bias | 431-450 | Acidic residues | ||||
Sequence: NDDENDEDEEEGEEEDADGH |
Sequence similarities
Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length529
- Mass (Da)60,485
- Last updated2003-06-01 v2
- Checksum0671C8143EFB8D21
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 336-363 | Acidic residues | ||||
Sequence: EDLGEDEDDSDDSKSMEDIQEEPEDLEK | ||||||
Compositional bias | 411-430 | Basic and acidic residues | ||||
Sequence: EGYKDIELPPEDFKRPADSE | ||||||
Compositional bias | 431-450 | Acidic residues | ||||
Sequence: NDDENDEDEEEGEEEDADGH |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BX284601 EMBL· GenBank· DDBJ | CAC70109.2 EMBL· GenBank· DDBJ | Genomic DNA |