Q95JD4 · RHBG_RABIT

Function

function

Ammonium transporter involved in the maintenance of acid-base homeostasis. Transports ammonium and its related derivative methylammonium across the basolateral plasma membrane of epithelial cells likely contributing to renal transepithelial ammonia transport and ammonia metabolism. May transport either NH4+ or NH3 ammonia species predominantly mediating an electrogenic NH4+ transport (By similarity).
May act as a CO2 channel providing for renal acid secretion (By similarity).

Catalytic activity

  • NH4+(in) = NH4+(out)
    This reaction proceeds in the forward
    and the backward
    directions.
  • methylamine(out) = methylamine(in)
    This reaction proceeds in the forward direction.
  • CO2(out) = CO2(in)
    This reaction proceeds in the forward direction.

GO annotations

AspectTerm
Cellular Componentbasolateral plasma membrane
Cellular Componentspectrin-associated cytoskeleton
Molecular Functionammonium channel activity
Molecular Functionankyrin binding
Molecular Functioncarbon dioxide transmembrane transporter activity
Biological Processammonium homeostasis
Biological Processammonium transmembrane transport
Biological Processtransepithelial ammonium transport

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Ammonium transporter Rh type B
  • Alternative names
    • Rhesus blood group family type B glycoprotein (Rh family type B glycoprotein; Rh type B glycoprotein)

Gene names

    • Name
      RHBG

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Lagomorpha > Leporidae > Oryctolagus

Accessions

  • Primary accession
    Q95JD4

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Basolateral cell membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-13Cytoplasmic
Transmembrane14-34Helical
Topological domain35-61Extracellular
Transmembrane62-82Helical
Topological domain83-86Cytoplasmic
Transmembrane87-107Helical
Topological domain108-124Extracellular
Transmembrane125-145Helical
Topological domain146-149Cytoplasmic
Transmembrane150-170Helical
Topological domain171-178Extracellular
Transmembrane179-201Helical
Topological domain202-219Cytoplasmic
Transmembrane220-240Helical
Topological domain241-251Extracellular
Transmembrane252-272Helical
Topological domain273-282Cytoplasmic
Transmembrane283-303Helical
Topological domain304Extracellular
Transmembrane305-325Helical
Topological domain326-346Cytoplasmic
Transmembrane347-367Helical
Topological domain368-393Extracellular
Transmembrane394-414Helical
Topological domain415-458Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain, glycosylation.

TypeIDPosition(s)Description
ChainPRO_00002836041-458Ammonium transporter Rh type B
Glycosylation49N-linked (GlcNAc...) asparagine

Post-translational modification

N-glycosylated.

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Interacts (via C-terminus) with ANK2 and ANK3; required for targeting to the basolateral membrane.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, motif.

TypeIDPosition(s)Description
Region416-424Interaction with ANK3
Motif429-432Basolateral sorting signal

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    458
  • Mass (Da)
    49,425
  • Last updated
    2001-12-01 v1
  • Checksum
    0FC41E08EC78B357
MAKSPRRVAGRRLLLPLLCLFFQGATAILFAIFVRYDQQTDAALWHGGNHSNADNEFYFRYPSFQDVHAMVFVGFGFLMVFLQRYGYSSLGFTFLLGAFALQWATLVQGFLHSFHGGHIHVGMESLINADFCAGAVLISFGAVLGKTGPAQLLLMALLEVALFGLNEFVLLCLLGVRDAGGSMTIHTFGAYFGLVLSRVLYRPHLEKSQHRQGSVYHSDLFAMIGTIFLWIFWPSFNSALTSRGDGQPRTALNTYYSLTASTLSTFALSALVGKDGRLDMVHVQNAALAGGVVVGTASEMMLTPFGALAAGCLAGAISTLGYKFFTPILESKLKIQDTCGVHNLHGMPGVLGALLGALMTGLTTHEAYGDGLQSVFPLIAEGQRSATSQAIYQLFGLSVTLLFASAGGVLGGLLLKLPFLDAPPDSQCYEDQMCWEVPGEHGYEAQEALRVEEPDTEA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY013262
EMBL· GenBank· DDBJ
AAK14652.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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