Q95891 · NU3M_PERMA

Function

function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular ComponentNADH dehydrogenase complex
Molecular FunctionNADH dehydrogenase (ubiquinone) activity
Biological Processmitochondrial electron transport, NADH to ubiquinone

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADH-ubiquinone oxidoreductase chain 3
  • EC number
  • Alternative names
    • NADH dehydrogenase subunit 3

Gene names

    • Name
      MT-ND3
    • Synonyms
      MTND3, NADH3, ND3

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strains
    • Austericus
    • Coolidgei
    • Interdictus
    • Oreas
    • Rufinus
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Cricetidae > Neotominae > Peromyscus

Accessions

  • Primary accession
    Q95891
  • Secondary accessions
    • Q95894
    • Q95900
    • Q95902
    • Q95904

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane4-24Helical
Transmembrane55-75Helical
Transmembrane84-104Helical

Keywords

Phenotypes & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variant15in strain: Coolidgei
Natural variant20in strain: Austericus and Rufinus
Natural variant42in strain: Rufinus
Natural variant56in strain: Oreas
Natural variant84in strain: Coolidgei
Natural variant85in strain: Austericus, Coolidgei and Rufinus
Natural variant104in strain: Rufinus

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 7 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001177961-115NADH-ubiquinone oxidoreductase chain 3

Interaction

Subunit

Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. Interacts with TMEM186. Interacts with TMEM242 (By similarity).

Structure

Family & Domains

Sequence similarities

Belongs to the complex I subunit 3 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    115
  • Mass (Da)
    13,181
  • Last updated
    1998-07-15 v2
  • Checksum
    61B275469729EBB5
MNMLTALLVNITLSMLLIIVAFWLPQLNLYTEKANPYECGFDPMGSARLPFSMKFFLVAITFLLFDLEIALLLPLPWAIQMYNIDIMMLTAFILVSVLALGLAYEWLQKGLEWTE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U40062
EMBL· GenBank· DDBJ
AAB17909.1
EMBL· GenBank· DDBJ
Genomic DNA
U40063
EMBL· GenBank· DDBJ
AAB17912.1
EMBL· GenBank· DDBJ
Genomic DNA
U40249
EMBL· GenBank· DDBJ
AAB17924.1
EMBL· GenBank· DDBJ
Genomic DNA
U40250
EMBL· GenBank· DDBJ
AAB17927.1
EMBL· GenBank· DDBJ
Genomic DNA
U40251
EMBL· GenBank· DDBJ
AAB17930.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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