Q957U9 · Q957U9_HUMAN
- ProteinCytochrome c oxidase subunit 1
- GeneCO1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids516 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + 8 H+(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H+(out) + 2 H2OThis reaction proceeds in the forward direction.
4 RHEA-COMP:10350 + 8 H+ (in)CHEBI:15378+ CHEBI:15379 = 4 RHEA-COMP:14399 + 4 H+ (out)CHEBI:15378+ 2 CHEBI:15377
Cofactor
Protein has several cofactor binding sites:
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | respiratory chain complex IV | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | oxidative phosphorylation |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ957U9
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 18-37 | Helical | ||||
Sequence: LYLLFGAWAGVLGTALSLLI | ||||||
Transmembrane | 57-83 | Helical | ||||
Sequence: IVTAHAFVMIFFMVMPIMIGGFGNWLV | ||||||
Transmembrane | 104-128 | Helical | ||||
Sequence: LLPPSLLLLLASAMVEAGAGTGWTV | ||||||
Transmembrane | 148-171 | Helical | ||||
Sequence: FSLHLAGVSSILGAINFITTIINM | ||||||
Transmembrane | 183-210 | Helical | ||||
Sequence: LFVWSVLITAVLLLLSLPVLAAGITMLL | ||||||
Transmembrane | 243-261 | Helical | ||||
Sequence: VYILILPGFGMISHIVTYY | ||||||
Transmembrane | 268-291 | Helical | ||||
Sequence: FGYMGMVWAMMSIGFLGFIVWAHH | ||||||
Transmembrane | 303-325 | Helical | ||||
Sequence: AYFTSATMIIAIPTGVKVFSWLA | ||||||
Transmembrane | 337-359 | Helical | ||||
Sequence: AVLWALGFIFLFTVGGLTGIVLA | ||||||
Transmembrane | 379-400 | Helical | ||||
Sequence: YVLSMGAVFAIMGGFIHWFPLF | ||||||
Transmembrane | 412-430 | Helical | ||||
Sequence: IHFTIMFIGVNLTFFPQHF | ||||||
Transmembrane | 450-473 | Helical | ||||
Sequence: WNILSSVGSFISLTAVMLMIFMIW |
Keywords
- Cellular component
PTM/Processing
Proteomic databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-511 | Cytochrome oxidase subunit I profile | ||||
Sequence: MFADRWLFSTNHKDIGTLYLLFGAWAGVLGTALSLLIRAELGQPGNLLGNDHIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSLLLLLASAMVEAGAGTGWTVYPPLAGNYSHPGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGSNMKWSAAVLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFIHWFPLFSGYTLDQTYAKIHFTIMFIGVNLTFFPQHFLGLSGMPRRYSDYPDAYTTWNILSSVGSFISLTAVMLMIFMIWEAFASKRKVLMVEEPSMNLEWLYGCPPPYHTFEEPVYM |
Sequence similarities
Belongs to the heme-copper respiratory oxidase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length516
- Mass (Da)57,426
- Last updated2001-12-01 v1
- Checksum14C0F97BCBFE8086
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF347006 EMBL· GenBank· DDBJ | AAK17768.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY339446 EMBL· GenBank· DDBJ | AAP89610.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ112936 EMBL· GenBank· DDBJ | AAZ03038.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM030515 EMBL· GenBank· DDBJ | ADE33275.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ012226 EMBL· GenBank· DDBJ | ADM60881.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ045068 EMBL· GenBank· DDBJ | AEV50453.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ324900 EMBL· GenBank· DDBJ | AFA33462.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ702002 EMBL· GenBank· DDBJ | AFF63986.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX171079 EMBL· GenBank· DDBJ | AFN86853.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX153078 EMBL· GenBank· DDBJ | AFO24189.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC622061 EMBL· GenBank· DDBJ | AGJ95267.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF146287 EMBL· GenBank· DDBJ | AGT54376.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF451734 EMBL· GenBank· DDBJ | AGZ76177.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF849929 EMBL· GenBank· DDBJ | AHE78967.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ154801 EMBL· GenBank· DDBJ | AHW38074.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ185473 EMBL· GenBank· DDBJ | AID08560.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM101851 EMBL· GenBank· DDBJ | AIU60764.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM986586 EMBL· GenBank· DDBJ | AJV87742.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR135848 EMBL· GenBank· DDBJ | AKT94218.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX456898 EMBL· GenBank· DDBJ | APD58705.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX675308 EMBL· GenBank· DDBJ | APZ83702.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY496890 EMBL· GenBank· DDBJ | AQX91617.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY595633 EMBL· GenBank· DDBJ | ARD72855.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY670865 EMBL· GenBank· DDBJ | ASC44896.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF497490 EMBL· GenBank· DDBJ | ASQ39370.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF058276 EMBL· GenBank· DDBJ | ASS26662.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF498704 EMBL· GenBank· DDBJ | ASY00756.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP010714 EMBL· GenBank· DDBJ | BAG15084.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP009431 EMBL· GenBank· DDBJ | BAG38865.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM260606 EMBL· GenBank· DDBJ | CAJ98078.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH553664 EMBL· GenBank· DDBJ | QBY36633.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK059587 EMBL· GenBank· DDBJ | QCB17841.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN503411 EMBL· GenBank· DDBJ | QEW88520.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN516571 EMBL· GenBank· DDBJ | QFZ96893.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN540499 EMBL· GenBank· DDBJ | QGL53704.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN398670 EMBL· GenBank· DDBJ | QIQ23259.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT682522 EMBL· GenBank· DDBJ | QNA49609.1 EMBL· GenBank· DDBJ | Genomic DNA |