Q957U9 · Q957U9_HUMAN

  • Protein
    Cytochrome c oxidase subunit 1
  • Gene
    CO1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Cu cation (UniProtKB | Rhea| CHEBI:23378 )

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processoxidative phosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      CO1
    • Synonyms
      COI
      , COX1
      , MTCO1

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • F45
    • Mdmd13
    • EU08
    • CADASIL patient 49
    • SCsq0054
    • AA-13
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q957U9

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane18-37Helical
Transmembrane57-83Helical
Transmembrane104-128Helical
Transmembrane148-171Helical
Transmembrane183-210Helical
Transmembrane243-261Helical
Transmembrane268-291Helical
Transmembrane303-325Helical
Transmembrane337-359Helical
Transmembrane379-400Helical
Transmembrane412-430Helical
Transmembrane450-473Helical

Keywords

PTM/Processing

Proteomic databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-511Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    516
  • Mass (Da)
    57,426
  • Last updated
    2001-12-01 v1
  • Checksum
    14C0F97BCBFE8086
MFADRWLFSTNHKDIGTLYLLFGAWAGVLGTALSLLIRAELGQPGNLLGNDHIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSLLLLLASAMVEAGAGTGWTVYPPLAGNYSHPGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGSNMKWSAAVLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFIHWFPLFSGYTLDQTYAKIHFTIMFIGVNLTFFPQHFLGLSGMPRRYSDYPDAYTTWNILSSVGSFISLTAVMLMIFMIWEAFASKRKVLMVEEPSMNLEWLYGCPPPYHTFEEPVYMKSKQK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF347006
EMBL· GenBank· DDBJ
AAK17768.1
EMBL· GenBank· DDBJ
Genomic DNA
AY339446
EMBL· GenBank· DDBJ
AAP89610.1
EMBL· GenBank· DDBJ
Genomic DNA
DQ112936
EMBL· GenBank· DDBJ
AAZ03038.1
EMBL· GenBank· DDBJ
Genomic DNA
HM030515
EMBL· GenBank· DDBJ
ADE33275.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ012226
EMBL· GenBank· DDBJ
ADM60881.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ045068
EMBL· GenBank· DDBJ
AEV50453.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ324900
EMBL· GenBank· DDBJ
AFA33462.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ702002
EMBL· GenBank· DDBJ
AFF63986.1
EMBL· GenBank· DDBJ
Genomic DNA
JX171079
EMBL· GenBank· DDBJ
AFN86853.1
EMBL· GenBank· DDBJ
Genomic DNA
JX153078
EMBL· GenBank· DDBJ
AFO24189.1
EMBL· GenBank· DDBJ
Genomic DNA
KC622061
EMBL· GenBank· DDBJ
AGJ95267.1
EMBL· GenBank· DDBJ
Genomic DNA
KF146287
EMBL· GenBank· DDBJ
AGT54376.1
EMBL· GenBank· DDBJ
Genomic DNA
KF451734
EMBL· GenBank· DDBJ
AGZ76177.1
EMBL· GenBank· DDBJ
Genomic DNA
KF849929
EMBL· GenBank· DDBJ
AHE78967.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ154801
EMBL· GenBank· DDBJ
AHW38074.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ185473
EMBL· GenBank· DDBJ
AID08560.1
EMBL· GenBank· DDBJ
Genomic DNA
KM101851
EMBL· GenBank· DDBJ
AIU60764.1
EMBL· GenBank· DDBJ
Genomic DNA
KM986586
EMBL· GenBank· DDBJ
AJV87742.1
EMBL· GenBank· DDBJ
Genomic DNA
KR135848
EMBL· GenBank· DDBJ
AKT94218.1
EMBL· GenBank· DDBJ
Genomic DNA
KX456898
EMBL· GenBank· DDBJ
APD58705.1
EMBL· GenBank· DDBJ
Genomic DNA
KX675308
EMBL· GenBank· DDBJ
APZ83702.1
EMBL· GenBank· DDBJ
Genomic DNA
KY496890
EMBL· GenBank· DDBJ
AQX91617.1
EMBL· GenBank· DDBJ
Genomic DNA
KY595633
EMBL· GenBank· DDBJ
ARD72855.1
EMBL· GenBank· DDBJ
Genomic DNA
KY670865
EMBL· GenBank· DDBJ
ASC44896.1
EMBL· GenBank· DDBJ
Genomic DNA
MF497490
EMBL· GenBank· DDBJ
ASQ39370.1
EMBL· GenBank· DDBJ
Genomic DNA
MF058276
EMBL· GenBank· DDBJ
ASS26662.1
EMBL· GenBank· DDBJ
Genomic DNA
MF498704
EMBL· GenBank· DDBJ
ASY00756.1
EMBL· GenBank· DDBJ
Genomic DNA
AP010714
EMBL· GenBank· DDBJ
BAG15084.1
EMBL· GenBank· DDBJ
Genomic DNA
AP009431
EMBL· GenBank· DDBJ
BAG38865.1
EMBL· GenBank· DDBJ
Genomic DNA
AM260606
EMBL· GenBank· DDBJ
CAJ98078.1
EMBL· GenBank· DDBJ
Genomic DNA
MH553664
EMBL· GenBank· DDBJ
QBY36633.1
EMBL· GenBank· DDBJ
Genomic DNA
MK059587
EMBL· GenBank· DDBJ
QCB17841.1
EMBL· GenBank· DDBJ
Genomic DNA
MN503411
EMBL· GenBank· DDBJ
QEW88520.1
EMBL· GenBank· DDBJ
Genomic DNA
MN516571
EMBL· GenBank· DDBJ
QFZ96893.1
EMBL· GenBank· DDBJ
Genomic DNA
MN540499
EMBL· GenBank· DDBJ
QGL53704.1
EMBL· GenBank· DDBJ
Genomic DNA
MN398670
EMBL· GenBank· DDBJ
QIQ23259.1
EMBL· GenBank· DDBJ
Genomic DNA
MT682522
EMBL· GenBank· DDBJ
QNA49609.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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