Q95165 · SCNNB_CANLF

Function

function

Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.

Activity regulation

Activated by WNK1, WNK2, WNK3 and WNK4.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentapical plasma membrane
Cellular Componentcytoplasmic vesicle membrane
Cellular Componentplasma membrane
Cellular Componentsodium channel complex
Molecular Functionligand-gated sodium channel activity
Biological Processmulticellular organismal-level water homeostasis
Biological Processsensory perception of taste
Biological Processsodium ion homeostasis
Biological Processsodium ion transmembrane transport

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Amiloride-sensitive sodium channel subunit beta
  • Alternative names
    • Beta-NaCH
    • Epithelial Na(+) channel subunit beta (Beta-ENaC)
    • Nonvoltage-gated sodium channel 1 subunit beta
    • SCNEB

Gene names

    • Name
      SCNN1B

Organism names

Accessions

  • Primary accession
    Q95165
  • Secondary accessions
    • F1PGD1

Proteomes

Organism-specific databases

Subcellular Location

Apical cell membrane
; Multi-pass membrane protein
Note: Apical membrane of epithelial cells.

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-50Cytoplasmic
Transmembrane51-71Helical; Name=1
Topological domain72-533Extracellular
Transmembrane534-554Helical; Name=2
Topological domain555-641Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain, glycosylation, modified residue.

TypeIDPosition(s)Description
ChainPRO_00001812671-641Amiloride-sensitive sodium channel subunit beta
Glycosylation141N-linked (GlcNAc...) asparagine
Glycosylation261N-linked (GlcNAc...) asparagine
Modified residue634Phosphoserine
Modified residue636Phosphoserine

Post-translational modification

Phosphorylated on serine and threonine residues. Aldosterone and insulin increase the basal level of phosphorylation.
N-glycosylated. N-glycosylation is required for interaction with BPIFA1.

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Heterotrimer containing an alpha/SCNN1A, a beta/SCNN1B and a gamma/SCNN1G subunit. An additional delta/SCNN1D subunit exists only in some organisms and can replace the alpha/SCNN1A subunit to form an alternative channel with specific properties. Interacts with NEDD4 (via WW domains). Interacts with NEDD4L (via WW domains). Interacts with WWP1 (via WW domains). Interacts with WWP2 (via WW domains). Interacts with the full-length immature form of PCSK9 (pro-PCSK9). Interacts (N-glycosylated) with BPIFA1; the interaction is direct and inhibits the proteolytic processing of SCNN1A and SCNN1G and the activation of ENaC.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region593-624Disordered
Compositional bias605-621Pro residues

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    641
  • Mass (Da)
    72,654
  • Last updated
    2015-04-29 v2
  • Checksum
    5A040E85895D751E
MHLKKYLLKGLHRLQKGPGYSYKELLVWYCNNTNTHGPKRIICEGPKKKAMWFLITLLFTSLVCWQWGVFIRTYLSWEVSVSLSLGFKTMDFPAVTICNASPFQYSKVKHLLRDLDELMEAVLERILAPEHSDANATRTLNVTMWNYTPLVLIDEQNPHCPVVLDLFGDIHNGSASSSPAPARSCTVHGCKVAMRLCSLNGTVCTFRNFTSATQAVTEWYLLQATNIFSQVPQRELVEMSYPAERLILACLFGAEPCSYRNFTSIFHPDYGNCYIFNWGMTEKALPSANPGAEFGLKLILDIGQEDYVPFLTSTAGARLMLHEQRSYPFIKDEGIYAMSGTETSIGVLVDRLERKGEPYSQCTVNGSDVPVRNLYSDYNTTYSIQACIRSCFQDHMIQNCSCAHYLYPLPRGERYCNNREFPDWAYCYSHLRMSVAQRETCINMCKESCNDTQYKMTISMADWPSEASEDWIFHVLSQERDQSTNITLSRKGVVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVLCLIEFGEILIDFVWITIIKLVAFAKSLRQKRAQARYAGPPPTVAELVEAHTNFGFQPDVARPGPDPGTYPDEQTLPIPGTPPPNYDSLRLQPLDVIESDSEGDAI

Features

Showing features for sequence conflict, compositional bias.

TypeIDPosition(s)Description
Sequence conflict567in Ref. 2; AAB09034
Compositional bias605-621Pro residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAEX03004450
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
U68062
EMBL· GenBank· DDBJ
AAB09034.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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