Q95161 · Q95161_CANLF
- ProteinAngiotensin-converting enzyme
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Soluble form that is released in blood plasma and other body fluids following proteolytic cleavage in the juxtamembrane stalk region.
Catalytic activity
- H2O + Leu-enkephalin = L-phenylalanyl-L-leucine + L-tyrosylglycylglycineThis reaction proceeds in the forward direction.
- H2O + Met-enkephalin = L-phenylalanyl-L-methionine + L-tyrosylglycylglycineThis reaction proceeds in the forward direction.
- H2O + Met-enkephalin-Arg-Phe = L-arginyl-L-phenylalanine + Met-enkephalinThis reaction proceeds in the forward direction.
- H2O + neurotensin = L-isoleucyl-L-leucine + neurotensin(1-11)This reaction proceeds in the forward direction.
- H2O + substance P = Gly-L-Leu-L-Met-NH2 + substance P(1-8)This reaction proceeds in the forward direction.
- H2O + substance P = L-Leu-L-Met-NH2 + substance P(1-9)This reaction proceeds in the forward direction.
- H2O + substance P = L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2 + substance P(1-6)This reaction proceeds in the forward direction.
- bradykinin + H2O = bradykinin(1-7) + L-Phe-L-ArgThis reaction proceeds in the forward direction.
- goralatide + H2O = L-lysyl-L-proline + N-acetyl-L-seryl-L-aspartateThis reaction proceeds in the forward direction.
Cofactor
Protein has several cofactor binding sites:
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | extracellular region | |
Cellular Component | membrane | |
Molecular Function | metallopeptidase activity | |
Molecular Function | peptidyl-dipeptidase activity | |
Biological Process | proteolysis |
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameAngiotensin-converting enzyme
- EC number
- Alternative names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Canidae > Canis
Accessions
- Primary accessionQ95161
PTM/Processing
Keywords
- PTM
Structure
Sequence
- Sequence statusFragment
- Length54
- Mass (Da)6,318
- Last updated1997-02-01 v1
- ChecksumB31B5DFADF45E367
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: A | ||||||
Non-terminal residue | 54 | |||||
Sequence: R |