Q94P91 · Q94P91_HUMAN
- ProteinNADH-ubiquinone oxidoreductase chain 1
- GeneND1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids318 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
Catalytic activity
- a ubiquinone + 5 H+(in) + NADH = a ubiquinol + 4 H+(out) + NAD+
a ubiquinone RHEA-COMP:9565 + 5 H+ (in)CHEBI:15378+ CHEBI:57945 = a ubiquinol RHEA-COMP:9566 + 4 H+ (out)CHEBI:15378+ CHEBI:57540
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | respirasome | |
Molecular Function | NADH dehydrogenase (ubiquinone) activity |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNADH-ubiquinone oxidoreductase chain 1
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ94P91
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 6-23 | Helical | ||||
Sequence: LLLLIVPILIAMAFLMLT | ||||||
Transmembrane | 68-86 | Helical | ||||
Sequence: ITLYITAPTLALTIALLLW | ||||||
Transmembrane | 98-119 | Helical | ||||
Sequence: LNLGLLFILATSSLAVYSILWS | ||||||
Transmembrane | 140-160 | Helical | ||||
Sequence: ISYEVTLAIILLSTLLMSGSF | ||||||
Transmembrane | 172-191 | Helical | ||||
Sequence: LWLLLPSWPLAMMWFISTLA | ||||||
Transmembrane | 220-243 | Helical | ||||
Sequence: FALFFMAEYTNIIMMNTLTTTIFL | ||||||
Transmembrane | 255-273 | Helical | ||||
Sequence: YTTYFVTKTLLLTSLFLWI | ||||||
Transmembrane | 293-314 | Helical | ||||
Sequence: FLPLTLALLMWYVSMPITISSI |
Keywords
- Cellular component
PTM/Processing
Proteomic databases
Structure
Sequence
- Sequence statusComplete
- Length318
- Mass (Da)35,691
- Last updated2001-12-01 v1
- Checksum6E7B62BE940528E9
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF346973 EMBL· GenBank· DDBJ | AAK17337.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF347010 EMBL· GenBank· DDBJ | AAK17818.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ112773 EMBL· GenBank· DDBJ | AAZ00917.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ282460 EMBL· GenBank· DDBJ | ABB79040.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ981469 EMBL· GenBank· DDBJ | ABI51846.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF153787 EMBL· GenBank· DDBJ | ABL60217.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF657254 EMBL· GenBank· DDBJ | ABR93270.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU007835 EMBL· GenBank· DDBJ | ABS57681.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU095534 EMBL· GenBank· DDBJ | ABU46833.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU095236 EMBL· GenBank· DDBJ | ABU47626.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU200759 EMBL· GenBank· DDBJ | ABW72886.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU443511 EMBL· GenBank· DDBJ | ACA01257.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU482334 EMBL· GenBank· DDBJ | ACA22267.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU660536 EMBL· GenBank· DDBJ | ACC86275.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU725621 EMBL· GenBank· DDBJ | ACD76628.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ383207 EMBL· GenBank· DDBJ | ACM69817.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ951506 EMBL· GenBank· DDBJ | ACQ74789.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GQ301868 EMBL· GenBank· DDBJ | ACT15698.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU213240 EMBL· GenBank· DDBJ | ADA58461.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM030524 EMBL· GenBank· DDBJ | ADE33390.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM357813 EMBL· GenBank· DDBJ | ADI79445.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM185237 EMBL· GenBank· DDBJ | ADK61625.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM765462 EMBL· GenBank· DDBJ | ADK66542.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ012089 EMBL· GenBank· DDBJ | ADM59098.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ287872 EMBL· GenBank· DDBJ | ADO50681.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ873539 EMBL· GenBank· DDBJ | ADY75045.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JF824843 EMBL· GenBank· DDBJ | AEG62507.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN253398 EMBL· GenBank· DDBJ | AEM54921.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ044819 EMBL· GenBank· DDBJ | AEV47214.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ245763 EMBL· GenBank· DDBJ | AEY71360.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ701964 EMBL· GenBank· DDBJ | AFF63490.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC257284 EMBL· GenBank· DDBJ | AGE01052.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC533515 EMBL· GenBank· DDBJ | AGK64933.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC911577 EMBL· GenBank· DDBJ | AGO94241.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF056257 EMBL· GenBank· DDBJ | AGT52528.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC252367 EMBL· GenBank· DDBJ | AGX90148.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF450838 EMBL· GenBank· DDBJ | AGZ64527.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF148102 EMBL· GenBank· DDBJ | AGZ96173.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF849970 EMBL· GenBank· DDBJ | AHE79498.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF874362 EMBL· GenBank· DDBJ | AHH00438.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ154168 EMBL· GenBank· DDBJ | AHW29843.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM986549 EMBL· GenBank· DDBJ | AJV87259.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP346020 EMBL· GenBank· DDBJ | AKB99984.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR135862 EMBL· GenBank· DDBJ | AKT94398.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU131384 EMBL· GenBank· DDBJ | AMB50881.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT725924 EMBL· GenBank· DDBJ | ANA92815.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX358482 EMBL· GenBank· DDBJ | ANY28147.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX456477 EMBL· GenBank· DDBJ | APD53231.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY409377 EMBL· GenBank· DDBJ | AQU31311.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY595552 EMBL· GenBank· DDBJ | ARD71800.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY671021 EMBL· GenBank· DDBJ | ASC46922.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF362759 EMBL· GenBank· DDBJ | ASF84561.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY645567 EMBL· GenBank· DDBJ | ASR13148.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF055770 EMBL· GenBank· DDBJ | ASR93935.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF588857 EMBL· GenBank· DDBJ | ATI24541.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF621114 EMBL· GenBank· DDBJ | ATP05475.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF381576 EMBL· GenBank· DDBJ | AUR43628.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG272615 EMBL· GenBank· DDBJ | AVL85415.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH359190 EMBL· GenBank· DDBJ | AWV63604.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH499979 EMBL· GenBank· DDBJ | AXT17243.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH448973 EMBL· GenBank· DDBJ | AYW04361.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH981862 EMBL· GenBank· DDBJ | AZJ14176.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP008275 EMBL· GenBank· DDBJ | BAE07558.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP008738 EMBL· GenBank· DDBJ | BAE13579.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP010695 EMBL· GenBank· DDBJ | BAG14835.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP009441 EMBL· GenBank· DDBJ | BAG38993.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK128879 EMBL· GenBank· DDBJ | QBB88315.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH553686 EMBL· GenBank· DDBJ | QBY36891.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK059505 EMBL· GenBank· DDBJ | QCB16773.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK134361 EMBL· GenBank· DDBJ | QGW54988.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN398774 EMBL· GenBank· DDBJ | QIQ24609.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN849635 EMBL· GenBank· DDBJ | QKT23789.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN687158 EMBL· GenBank· DDBJ | QLH90882.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT418946 EMBL· GenBank· DDBJ | QMP90819.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK795828 EMBL· GenBank· DDBJ | QQP22575.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN857259 EMBL· GenBank· DDBJ | QTK13922.1 EMBL· GenBank· DDBJ | Genomic DNA |