Q94NE8 · Q94NE8_SORCA

Function

function

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.

Cofactor

Protein has several cofactor binding sites:
heme b (UniProtKB | Rhea| CHEBI:60344 )

Note: Binds 2 heme groups non-covalently.
heme (UniProtKB | Rhea| CHEBI:30413 )

Note: Binds 2 heme groups non-covalently.

Features

Showing features for binding site.

137950100150200250300350
TypeIDPosition(s)Description
Binding site83Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue
Binding site97Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue
Binding site182Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue
Binding site196Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue
Binding site201a ubiquinone (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex III
Molecular Functionmetal ion binding
Molecular Functionubiquinol-cytochrome-c reductase activity
Biological Processmitochondrial electron transport, ubiquinol to cytochrome c

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome b

Gene names

    • Name
      cytb

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strains
    • 94sc1
    • 95/7/12-3
    • AH301
    • AH302
    • AH304
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Eulipotyphla > Soricidae > Soricinae > Sorex

Accessions

  • Primary accession
    Q94NE8

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane30-56Helical
Transmembrane77-98Helical
Transmembrane113-133Helical
Transmembrane140-158Helical
Transmembrane178-200Helical
Transmembrane229-246Helical
Transmembrane288-307Helical
Transmembrane319-340Helical
Transmembrane346-372Helical

Keywords

Interaction

Subunit

The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-209Cytochrome b/b6 N-terminal region profile
Domain210-379Cytochrome b/b6 C-terminal region profile

Sequence similarities

Belongs to the cytochrome b family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    379
  • Mass (Da)
    42,661
  • Last updated
    2001-12-01 v1
  • Checksum
    CBBC14AA2B67CD86
MTNLRKTHPLMKIVNSSFIDLPAPSNISSWWNFGSLLGVCLIIQILTGLFLAMHYTSDTMTAFSSVTHICRDVNYGWLIRYLHANGASMFFICLFLHVGRGLYYGSYMYLETWNIGVLLLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGSDLVEWIWGGFSVDKATLTRFFAFHFILPFIVAALAGVHLLFLHETGSNNPSGLCSDADKIPFHPYYTIKDILGVLLFILILTSLVLFSPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALALSILILALVPFLHTSKQRSMMFRPFSQCLFWILVADLLTLTWIGGQPVEHPFIIIGQLASILYFLLILVIMPITSLFENNLLKW

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KF974362
EMBL· GenBank· DDBJ
AID54676.1
EMBL· GenBank· DDBJ
Genomic DNA
KU760862
EMBL· GenBank· DDBJ
ANA78304.1
EMBL· GenBank· DDBJ
Genomic DNA
KU760863
EMBL· GenBank· DDBJ
ANA78305.1
EMBL· GenBank· DDBJ
Genomic DNA
KU760866
EMBL· GenBank· DDBJ
ANA78308.1
EMBL· GenBank· DDBJ
Genomic DNA
KU760867
EMBL· GenBank· DDBJ
ANA78309.1
EMBL· GenBank· DDBJ
Genomic DNA
KU760869
EMBL· GenBank· DDBJ
ANA78311.1
EMBL· GenBank· DDBJ
Genomic DNA
KU760870
EMBL· GenBank· DDBJ
ANA78312.1
EMBL· GenBank· DDBJ
Genomic DNA
KU760871
EMBL· GenBank· DDBJ
ANA78313.1
EMBL· GenBank· DDBJ
Genomic DNA
KU760872
EMBL· GenBank· DDBJ
ANA78314.1
EMBL· GenBank· DDBJ
Genomic DNA
KU760873
EMBL· GenBank· DDBJ
ANA78315.1
EMBL· GenBank· DDBJ
Genomic DNA
KU760874
EMBL· GenBank· DDBJ
ANA78316.1
EMBL· GenBank· DDBJ
Genomic DNA
KU760876
EMBL· GenBank· DDBJ
ANA78318.1
EMBL· GenBank· DDBJ
Genomic DNA
KU760877
EMBL· GenBank· DDBJ
ANA78319.1
EMBL· GenBank· DDBJ
Genomic DNA
KU760878
EMBL· GenBank· DDBJ
ANA78320.1
EMBL· GenBank· DDBJ
Genomic DNA
KU760879
EMBL· GenBank· DDBJ
ANA78321.1
EMBL· GenBank· DDBJ
Genomic DNA
KU760880
EMBL· GenBank· DDBJ
ANA78322.1
EMBL· GenBank· DDBJ
Genomic DNA
KU760881
EMBL· GenBank· DDBJ
ANA78323.1
EMBL· GenBank· DDBJ
Genomic DNA
KU760882
EMBL· GenBank· DDBJ
ANA78324.1
EMBL· GenBank· DDBJ
Genomic DNA
AB028558
EMBL· GenBank· DDBJ
BAB61678.1
EMBL· GenBank· DDBJ
Genomic DNA
AB028559
EMBL· GenBank· DDBJ
BAB61679.1
EMBL· GenBank· DDBJ
Genomic DNA

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