Q94JM3 · ARFB_ARATH

Function

function

Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs). Could act as transcriptional activator or repressor. Formation of heterodimers with Aux/IAA proteins may alter their ability to modulate early auxin response genes expression. Promotes flowering, stamen development, floral organ abscission and fruit dehiscence. Functions independently of ethylene and cytokinin response pathways. May act as a repressor of cell division and organ growth.

Caution

Was originally erroneously termed IAA26 and IAA30 (Ref.5).

Features

Showing features for dna binding.

1859100200300400500600700800
TypeIDPosition(s)Description
DNA binding164-266TF-B3

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA-binding transcription factor activity
Molecular Functionsequence-specific DNA binding
Biological Processauxin-activated signaling pathway
Biological Processfloral organ abscission
Biological Processfruit dehiscence
Biological Processleaf senescence
Biological Processnegative regulation of cell population proliferation
Biological Processnegative regulation of DNA-templated transcription
Biological Processplant ovule development
Biological Processpositive regulation of flower development
Biological Processpositive regulation of potassium ion import across plasma membrane
Biological Processresponse to abscisic acid

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Auxin response factor 2
  • Alternative names
    • ARF1-binding protein (ARF1-BP)
    • Protein MEGAINTEGUMENTA

Gene names

    • Name
      ARF2
    • Synonyms
      MNT
    • ORF names
      MTG10.3
    • Ordered locus names
      At5g62000

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q94JM3
  • Secondary accessions
    • O23671
    • Q56YL7
    • Q56YP4
    • Q56YR7
    • Q9C5W5
    • Q9FIT6

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

Large, dark green rosette leaves, delayed flowering, thick and long inflorescence, abnormal flower morphology and sterility in early formed flowers, but fertility in late-formed flowers. Delayed senescence and abscission. Increased seed size and weight, and extra cell division and expansion in many organs.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 51 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001115061-859Auxin response factor 2

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in the whole plant.

Developmental stage

Expressed in the sepals and carpels of young flower buds. At stage 10 of flower development, expression in the carpels becomes restricted to the style. Also expressed in anthers and filaments. At stage 13, expressed in the region at the top of the pedicel, including the abscission zone. Expressed in developing siliques.

Gene expression databases

Structure

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias1-47Polar residues
Region1-48Disordered
Compositional bias396-414Pro residues
Region396-442Disordered
Compositional bias416-431Polar residues
Region687-736Disordered
Compositional bias711-736Polar residues
Domain733-817PB1
Region829-859Disordered
Compositional bias845-859Polar residues

Domain

Interactions between auxin response factors (ARFs) and Aux/IAA proteins occur through their C-terminal dimerization domains III and IV.

Sequence similarities

Belongs to the ARF family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete

This entry describes 1 isoforms produced by Alternative splicing. A number of isoforms are produced. According to EST sequences.

Q94JM3-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    859
  • Mass (Da)
    95,701
  • Last updated
    2004-04-13 v2
  • Checksum
    6B75171D7FF0E66B
MASSEVSMKGNRGGDNFSSSGFSDPKETRNVSVAGEGQKSNSTRSAAAERALDPEAALYRELWHACAGPLVTVPRQDDRVFYFPQGHIEQVEASTNQAAEQQMPLYDLPSKLLCRVINVDLKAEADTDEVYAQITLLPEANQDENAIEKEAPLPPPPRFQVHSFCKTLTASDTSTHGGFSVLRRHADECLPPLDMSRQPPTQELVAKDLHANEWRFRHIFRGQPRRHLLQSGWSVFVSSKRLVAGDAFIFLRGENGELRVGVRRAMRQQGNVPSSVISSHSMHLGVLATAWHAISTGTMFTVYYKPRTSPSEFIVPFDQYMESVKNNYSIGMRFKMRFEGEEAPEQRFTGTIVGIEESDPTRWPKSKWRSLKVRWDETSSIPRPDRVSPWKVEPALAPPALSPVPMPRPKRPRSNIAPSSPDSSMLTREGTTKANMDPLPASGLSRVLQGQEYSTLRTKHTESVECDAPENSVVWQSSADDDKVDVVSGSRRYGSENWMSSARHEPTYTDLLSGFGTNIDPSHGQRIPFYDHSSSPSMPAKRILSDSEGKFDYLANQWQMIHSGLSLKLHESPKVPAATDASLQGRCNVKYSEYPVLNGLSTENAGGNWPIRPRALNYYEEVVNAQAQAQAREQVTKQPFTIQEETAKSREGNCRLFGIPLTNNMNGTDSTMSQRNNLNDAAGLTQIASPKVQDLSDQSKGSKSTNDHREQGRPFQTNNPHPKDAQTKTNSSRSCTKVHKQGIALGRSVDLSKFQNYEELVAELDRLFEFNGELMAPKKDWLIVYTDEENDMMLVGDDPWQEFCCMVRKIFIYTKEEVRKMNPGTLSCRSEEEAVVGEGSDAKDAKSASNPSLSSAGNS

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
F4K536F4K536_ARATHARF2853

Sequence caution

The sequence AAC49752.1 differs from that shown. Reason: Erroneous initiation
The sequence AAK55665.1 differs from that shown. Reason: Frameshift
The sequence AAN46837.1 differs from that shown. Reason: Frameshift
The sequence CAD29696.1 differs from that shown. Reason: Erroneous initiation
The sequence CAD30210.1 differs from that shown. Reason: Erroneous initiation

Features

Showing features for compositional bias, sequence conflict.

TypeIDPosition(s)Description
Compositional bias1-47Polar residues
Compositional bias396-414Pro residues
Compositional bias416-431Polar residues
Sequence conflict491-492in Ref. 6; AAC49752 and 7; CAD29696/CAD30210
Sequence conflict520in Ref. 6; AAC49752 and 7; CAD29696/CAD30210
Sequence conflict596in Ref. 5; BAD93968
Sequence conflict675in Ref. 6; AAC49752 and 7; CAD29696/CAD30210
Compositional bias711-736Polar residues
Sequence conflict823in Ref. 6; AAC49752 and 7; CAD29696/CAD30210
Sequence conflict826in Ref. 5; BAD93959/BAD93897/BAD93891
Compositional bias845-859Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY669787
EMBL· GenBank· DDBJ
AAT67071.1
EMBL· GenBank· DDBJ
mRNA
AB016880
EMBL· GenBank· DDBJ
BAB10162.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002688
EMBL· GenBank· DDBJ
AED97548.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002688
EMBL· GenBank· DDBJ
AED97549.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002688
EMBL· GenBank· DDBJ
AED97550.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002688
EMBL· GenBank· DDBJ
ANM68885.1
EMBL· GenBank· DDBJ
Genomic DNA
AF336918
EMBL· GenBank· DDBJ
AAG53999.1
EMBL· GenBank· DDBJ
mRNA
AF378862
EMBL· GenBank· DDBJ
AAK55665.1
EMBL· GenBank· DDBJ
mRNA Frameshift
BT000784
EMBL· GenBank· DDBJ
AAN31923.1
EMBL· GenBank· DDBJ
mRNA
BT001072
EMBL· GenBank· DDBJ
AAN46837.1
EMBL· GenBank· DDBJ
mRNA Frameshift
AK221252
EMBL· GenBank· DDBJ
BAD93891.1
EMBL· GenBank· DDBJ
mRNA
AK221254
EMBL· GenBank· DDBJ
BAD93897.1
EMBL· GenBank· DDBJ
mRNA
AK221274
EMBL· GenBank· DDBJ
BAD93959.1
EMBL· GenBank· DDBJ
mRNA
AK221277
EMBL· GenBank· DDBJ
BAD93968.1
EMBL· GenBank· DDBJ
mRNA
AK221282
EMBL· GenBank· DDBJ
BAD93985.1
EMBL· GenBank· DDBJ
mRNA
AK221305
EMBL· GenBank· DDBJ
BAD94058.1
EMBL· GenBank· DDBJ
mRNA
U89771
EMBL· GenBank· DDBJ
AAC49752.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AJ441313
EMBL· GenBank· DDBJ
CAD29696.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AJ458328
EMBL· GenBank· DDBJ
CAD30210.1
EMBL· GenBank· DDBJ
mRNA Different initiation

Genome annotation databases

Similar Proteins

Disclaimer

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