Q94CL9 · KRP7_ARATH
- ProteinCyclin-dependent kinase inhibitor 7
- GeneKRP7
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids195 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Binds and inhibits CYCD2-1/CDKA-1 complex kinase activity. May target specifically CDKA-1.
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | male germ cell nucleus | |
Cellular Component | nucleoplasm | |
Molecular Function | cyclin-dependent protein serine/threonine kinase inhibitor activity | |
Biological Process | negative regulation of cyclin-dependent protein serine/threonine kinase activity |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameCyclin-dependent kinase inhibitor 7
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ94CL9
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Homogeneously distributed. Accumulates strongly in vegetative cell nuclei immediately after asymmetric division and disappears later.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000294091 | 1-195 | Cyclin-dependent kinase inhibitor 7 | |||
Sequence: MSETKPKRDSEYEGSNIKRMRLDDDDDVLRSPTRTLSSSSSSSLAYSVSDSGGFCSVALSEEEDDHLSSSISSGCSSSETNEIATRLPFSDLEAHEISETEISTLLTNNFRKQGISSSENLGETAEMDSATTEMRDQRKTEKKKKMEKSPTQAELDDFFSAAERYEQKRFTEKYNYDIVNDTPLEGRYQWVSLKP | ||||||
Modified residue | 151 | Phosphothreonine; by KIN10 | ||||
Sequence: T |
Post-translational modification
Ubiquitinated by SCF(FBL17). Ubiquitination leads to its subsequent degradation, thus controlling cell cycle progression.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in flowers, in developing pollen, and at lower levels in roots and leaves.
Developmental stage
Present in uninucleate microspore and bicellular pollen.
Gene expression databases
Interaction
Subunit
Specifically interacts with CDKA-1, but not with CDKB1-1. Interacts with CYCD4-1. Binds to FBL17.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q94CL9 | CDKA-1 P24100 | 3 | EBI-1773344, EBI-371713 | |
BINARY | Q94CL9 | CYCD4-1 Q8LGA1 | 2 | EBI-1773344, EBI-1253202 | |
BINARY | Q94CL9 | FBL17 Q8W104 | 4 | EBI-1773344, EBI-2026732 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-31 | Basic and acidic residues | ||||
Sequence: MSETKPKRDSEYEGSNIKRMRLDDDDDVLRS | ||||||
Region | 1-50 | Disordered | ||||
Sequence: MSETKPKRDSEYEGSNIKRMRLDDDDDVLRSPTRTLSSSSSSSLAYSVSD | ||||||
Compositional bias | 32-50 | Polar residues | ||||
Sequence: PTRTLSSSSSSSLAYSVSD | ||||||
Region | 61-80 | Disordered | ||||
Sequence: EEEDDHLSSSISSGCSSSET | ||||||
Region | 117-154 | Disordered | ||||
Sequence: SSENLGETAEMDSATTEMRDQRKTEKKKKMEKSPTQAE | ||||||
Compositional bias | 129-152 | Basic and acidic residues | ||||
Sequence: SATTEMRDQRKTEKKKKMEKSPTQ |
Sequence similarities
Belongs to the CDI family. ICK/KRP subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length195
- Mass (Da)21,965
- Last updated2007-07-10 v2
- Checksum6A7E0867B752E5FF
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A1P8ASU8 | A0A1P8ASU8_ARATH | ICK5 | 200 | ||
A0A1P8ASS0 | A0A1P8ASS0_ARATH | ICK5 | 178 |
Features
Showing features for compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-31 | Basic and acidic residues | ||||
Sequence: MSETKPKRDSEYEGSNIKRMRLDDDDDVLRS | ||||||
Compositional bias | 32-50 | Polar residues | ||||
Sequence: PTRTLSSSSSSSLAYSVSD | ||||||
Sequence conflict | 67 | in Ref. 1; CAC41621 | ||||
Sequence: L → R | ||||||
Compositional bias | 129-152 | Basic and acidic residues | ||||
Sequence: SATTEMRDQRKTEKKKKMEKSPTQ |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJ301558 EMBL· GenBank· DDBJ | CAC41621.1 EMBL· GenBank· DDBJ | mRNA | ||
AC011807 EMBL· GenBank· DDBJ | AAG13048.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002684 EMBL· GenBank· DDBJ | AEE32450.1 EMBL· GenBank· DDBJ | Genomic DNA |