Q94CL9 · KRP7_ARATH

Function

function

Binds and inhibits CYCD2-1/CDKA-1 complex kinase activity. May target specifically CDKA-1.

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmale germ cell nucleus
Cellular Componentnucleoplasm
Molecular Functioncyclin-dependent protein serine/threonine kinase inhibitor activity
Biological Processnegative regulation of cyclin-dependent protein serine/threonine kinase activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cyclin-dependent kinase inhibitor 7
  • Alternative names
    • Inhibitor/interactor of CDK protein 5
    • KIP-related protein 7

Gene names

    • Name
      KRP7
    • Synonyms
      ICK5
    • ORF names
      F14J22.14
    • Ordered locus names
      At1g49620

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q94CL9
  • Secondary accessions
    • Q9FX90

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Nucleus, nucleoplasm
Note: Homogeneously distributed. Accumulates strongly in vegetative cell nuclei immediately after asymmetric division and disappears later.

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00002940911-195Cyclin-dependent kinase inhibitor 7
Modified residue151Phosphothreonine; by KIN10

Post-translational modification

Ubiquitinated by SCF(FBL17). Ubiquitination leads to its subsequent degradation, thus controlling cell cycle progression.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in flowers, in developing pollen, and at lower levels in roots and leaves.

Developmental stage

Present in uninucleate microspore and bicellular pollen.

Gene expression databases

Interaction

Subunit

Specifically interacts with CDKA-1, but not with CDKB1-1. Interacts with CYCD4-1. Binds to FBL17.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q94CL9CDKA-1 P241003EBI-1773344, EBI-371713
BINARY Q94CL9CYCD4-1 Q8LGA12EBI-1773344, EBI-1253202
BINARY Q94CL9FBL17 Q8W1044EBI-1773344, EBI-2026732

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for compositional bias, region.

TypeIDPosition(s)Description
Compositional bias1-31Basic and acidic residues
Region1-50Disordered
Compositional bias32-50Polar residues
Region61-80Disordered
Region117-154Disordered
Compositional bias129-152Basic and acidic residues

Sequence similarities

Belongs to the CDI family. ICK/KRP subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    195
  • Mass (Da)
    21,965
  • Last updated
    2007-07-10 v2
  • Checksum
    6A7E0867B752E5FF
MSETKPKRDSEYEGSNIKRMRLDDDDDVLRSPTRTLSSSSSSSLAYSVSDSGGFCSVALSEEEDDHLSSSISSGCSSSETNEIATRLPFSDLEAHEISETEISTLLTNNFRKQGISSSENLGETAEMDSATTEMRDQRKTEKKKKMEKSPTQAELDDFFSAAERYEQKRFTEKYNYDIVNDTPLEGRYQWVSLKP

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1P8ASU8A0A1P8ASU8_ARATHICK5200
A0A1P8ASS0A0A1P8ASS0_ARATHICK5178

Features

Showing features for compositional bias, sequence conflict.

TypeIDPosition(s)Description
Compositional bias1-31Basic and acidic residues
Compositional bias32-50Polar residues
Sequence conflict67in Ref. 1; CAC41621
Compositional bias129-152Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ301558
EMBL· GenBank· DDBJ
CAC41621.1
EMBL· GenBank· DDBJ
mRNA
AC011807
EMBL· GenBank· DDBJ
AAG13048.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002684
EMBL· GenBank· DDBJ
AEE32450.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp