Q94CF0 · EHD1_ARATH

Function

function

Involved in endocytosis positive regulation. Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes (PubMed:18547399, PubMed:23342166).
Confers salt tolerance (PubMed:23342166).

Catalytic activity

Features

Showing features for binding site.

154550100150200250300350400450500
TypeIDPosition(s)Description
Binding site27Ca2+ 1 (UniProtKB | ChEBI)
Binding site29Ca2+ 1 (UniProtKB | ChEBI)
Binding site31Ca2+ 1 (UniProtKB | ChEBI)
Binding site33Ca2+ 1 (UniProtKB | ChEBI)
Binding site38Ca2+ 1 (UniProtKB | ChEBI)
Binding site61Ca2+ 2 (UniProtKB | ChEBI)
Binding site67Ca2+ 2 (UniProtKB | ChEBI)
Binding site72Ca2+ 2 (UniProtKB | ChEBI)
Binding site204-211GTP (UniProtKB | ChEBI)
Binding site309-313GTP (UniProtKB | ChEBI)
Binding site359GTP (UniProtKB | ChEBI)
Binding site395-398GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentendosome
Cellular Componentendosome membrane
Cellular Componentintracellular membrane-bounded organelle
Cellular Componentmembrane
Cellular Componentplasma membrane
Cellular Componentplasmodesma
Molecular Functioncalcium ion binding
Molecular FunctionG protein activity
Molecular FunctionGTP binding
Biological Processendocytic recycling
Biological Processendocytosis
Biological Processhyperosmotic salinity response
Biological Processprotein homooligomerization

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    EH domain-containing protein 1
  • EC number
  • Short names
    AtEHD1

Gene names

    • Name
      EHD1
    • ORF names
      MQC12.3
    • Ordered locus names
      At3g20290

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q94CF0
  • Secondary accessions
    • Q9LTR4

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

Early flowering in short-day growth conditions (PubMed:18547399).
Slightly slower endocytosis with delayed internalization (PubMed:18547399, PubMed:23342166).
Reduced Brefeldin A sensitivity (PubMed:23342166).

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis1-93Impaired endosomal subcellular location and delayed internalization.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 27 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004318051-545EH domain-containing protein 1

Proteomic databases

Expression

Induction

By salinity stress.

Gene expression databases

Interaction

Subunit

Homooligomer, and heterooligomer with EHD2.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region, coiled coil.

TypeIDPosition(s)Description
Domain14-49EF-hand 1
Domain15-93EH
Domain50-83EF-hand 2
Domain194-429Dynamin-type G
Region204-211G1 motif
Region230-231G2 motif
Region292-295G3 motif
Region358-361G4 motif
Region382G5 motif
Coiled coil467-490

Domain

The EH domain (1-93) is critical for vesicular localization.

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    545
  • Mass (Da)
    61,230
  • Last updated
    2001-12-01 v1
  • Checksum
    0E5B907504D70117
MEIESVAAGSCSKENQMIYKEWFEFSDSDGDGRITGNDAIKFFTMSNLPRPELKQIWAIADSKRQGYLGFKEFIVAMQLVSLAQTGHEISHEVLISDVDFKNINPPTMEGLGVLMAKKKHSSKSSDPNMNGSPAADTSLTAHWFSSKSSKKISLSSVTSIVDGLKRLYIQKLKPLEVAYRFNDFVSPLLTNSDFDAKPMVMLLGQYSTGKTTFIKHLLKSTYPGAHIGPEPTTDRFVVVMSGPDERSIPGNTVAVQADMPFSGLTTFGTAFLSKFECSQMPHPLLEHVTFVDTPGVLSGEKQRTQRAYDFTGVTSWFASKCDLILLLFDPHKLDVSDEFKRVISSLRGHDDKIRVVLNKADQVDTQQLMRVYGALMWSLGKVLNTPEVSRVYIGSFSDKPINEAATGPIGRELFEKEQDDLLADLKDIPKKACDRRINEFVKRARAAKIHAYIISHLKKEMPAIMGKAKAQQKLIDNLEDEFGKVQREHHLPKGDFPNVDHFREVLSGYNIDKFEKLKPKMLQTVDDMLGYDIPELLKNFKNPYD

Sequence caution

The sequence BAB02809.1 differs from that shown. Reason: Erroneous gene model prediction

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB024036
EMBL· GenBank· DDBJ
BAB02809.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
CP002686
EMBL· GenBank· DDBJ
AEE76359.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002686
EMBL· GenBank· DDBJ
AEE76360.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002686
EMBL· GenBank· DDBJ
ANM65913.1
EMBL· GenBank· DDBJ
Genomic DNA
AY034911
EMBL· GenBank· DDBJ
AAK59418.1
EMBL· GenBank· DDBJ
mRNA
BT004414
EMBL· GenBank· DDBJ
AAO42408.1
EMBL· GenBank· DDBJ
mRNA
AK317308
EMBL· GenBank· DDBJ
BAH19984.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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