Q94BT9 · ATOX1_ARATH

Function

function

Plays an important role in copper homeostasis by conferring tolerance to excess of copper and subclinical copper deficiency during vegetative stage. Can complement the yeast mutants atx1 and sod1.

Miscellaneous

Over-expression of ATX1 confers increased tolerance to copper excess as well as subclinical copper deficiency (PubMed:22555879), but over-expressing plants are hypersensitive to severe copper deficiency (PubMed:22899077).

Cofactor

Cu cation (UniProtKB | Rhea| CHEBI:23378 )

Note: Binds 1 copper ion per subunit.

Features

Showing features for binding site.

17610203040506070
MSQTVVLRVAMTCEGCVGAVKRVLGKMEGVESFDVDIKEQKVTVKGNVQPDAVLQTVTKTGKKTAFWEAEGETAKA
TypeIDPosition(s)Description
Binding site13Cu cation (UniProtKB | ChEBI)
Binding site16Cu cation (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentmitochondrion
Cellular Componentsecretory vesicle
Molecular Functionmetal ion binding
Biological Processcopper ion transport

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Copper transport protein ATX1
  • Alternative names
    • Copper chaperone ATX1

Gene names

    • Name
      ATX1
    • ORF names
      T6J19.6
    • Ordered locus names
      At1g66240

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q94BT9
  • Secondary accessions
    • C0Z3B8
    • Q9C7U6

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

No visible phenotype under normal growth conditions, but mutant plants have increased sensitivity to excess of copper.

PTM/Processing

Features

Showing features for initiator methionine, modified residue, chain.

TypeIDPosition(s)Description
Initiator methionine1Removed
Modified residue2N-acetylserine
ChainPRO_00004227602-76Copper transport protein ATX1

Keywords

Proteomic databases

PTM databases

Expression

Induction

Induced by excess of copper (at protein level).

Gene expression databases

Interaction

Subunit

Interacts with HMA5 and RAN1/HMA7.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain2-65HMA

Sequence similarities

Belongs to the ATX1 family.

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q94BT9-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    76
  • Mass (Da)
    8,158
  • Last updated
    2015-10-14 v2
  • Checksum
    30874B7A605AB8F0
MSQTVVLRVAMTCEGCVGAVKRVLGKMEGVESFDVDIKEQKVTVKGNVQPDAVLQTVTKTGKKTAFWEAEGETAKA

Q94BT9-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
F4ID99F4ID99_ARATHATX141

Sequence caution

The sequence AAG51766.1 differs from that shown. Reason: Erroneous initiation Extended N-terminus.
The sequence AAK64002.1 differs from that shown. Reason: Erroneous initiation Extended N-terminus.
The sequence AAL76156.1 differs from that shown. Reason: Erroneous initiation Extended N-terminus.
The sequence AEE34481.1 differs from that shown. Reason: Erroneous initiation Extended N-terminus.

Features

Showing features for alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Alternative sequenceVSP_0466141-10in isoform 2
Sequence conflict69in Ref. 4; BAH57197

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC066691
EMBL· GenBank· DDBJ
AAG51766.1
EMBL· GenBank· DDBJ
Genomic DNA Different initiation
CP002684
EMBL· GenBank· DDBJ
AEE34481.1
EMBL· GenBank· DDBJ
Genomic DNA Different initiation
CP002684
EMBL· GenBank· DDBJ
AEE34482.1
EMBL· GenBank· DDBJ
Genomic DNA
AY039898
EMBL· GenBank· DDBJ
AAK64002.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AY077678
EMBL· GenBank· DDBJ
AAL76156.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AK319082
EMBL· GenBank· DDBJ
BAH57197.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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