Q94BN0 · BT2_ARATH

Function

function

May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Plays a key role as a component of the TAC1-mediated telomerase activation pathway certainly by targeting a telomerase repressor to degradation. Seems to occupy an integral position in a complex signaling network that perceives, integrates, and responds to multiple, and sometimes competing, signals. Enhances responses to auxin in postgermination and vegetative development. Also negatively regulates ABA- and sugar-mediated inhibition of the germination. Essential for female and male gametophyte development.

Pathway

Protein modification; protein ubiquitination.

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular Functioncalmodulin binding
Molecular Functionmetal ion binding
Biological Processabscisic acid-activated signaling pathway
Biological Processauxin-activated signaling pathway
Biological Processcircadian rhythm
Biological Processembryo sac development
Biological Processpollen development
Biological Processprotein ubiquitination
Biological Processregulation of DNA-templated transcription
Biological Processresponse to abscisic acid
Biological Processresponse to auxin
Biological Processresponse to carbohydrate
Biological Processresponse to cold
Biological Processresponse to hydrogen peroxide
Biological Processresponse to jasmonic acid
Biological Processresponse to nitrate
Biological Processresponse to salicylic acid
Biological Processresponse to salt stress
Biological Processresponse to wounding
Biological Processsugar mediated signaling pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    BTB/POZ and TAZ domain-containing protein 2
  • Alternative names
    • BTB and TAZ domain protein 2

Gene names

    • Name
      BT2
    • ORF names
      T29H11.120
    • Ordered locus names
      At3g48360

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q94BN0
  • Secondary accessions
    • Q9STL6

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

Altered response to auxin. Blocked ability of TAC1 to induce telomerase. Hypersensitive response to both sugar and abscisic acid (ABA)-mediated inhibition of germination.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 56 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004061431-364BTB/POZ and TAZ domain-containing protein 2

Proteomic databases

Expression

Tissue specificity

Preferentially expressed in young leaves and roots.

Induction

Up-regulated by auxin (IAA), methyl jasmonate (MeJA), hydrogen peroxide and nitrates. Down-regulated by salicylic acid (SA), abscisic acid (ABA), hydrogen peroxide, sugars, cold and NaCl. Positively regulated by the transcriptional factor TAC1. Circadian-regulation; expression increase during the dark phase and decrease during the light phase.

Gene expression databases

Interaction

Subunit

Interacts with CUL3A. Interacts with GTE11/BET10 through the BTB domain.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntAct
BINARY Q94BN0CPK11 Q390167EBI-540986, EBI-979321
BINARY Q94BN0CPK4 Q388697EBI-540986, EBI-979475

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, motif, zinc finger, region.

Type
IDPosition(s)Description
Domain34-106BTB
Motif203-212Nuclear localization signal
Zinc finger215-316TAZ-type
Region327-350CaM-binding

Domain

The BTB/POZ domain mediates the interaction with some component of ubiquitin ligase complexes.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    364
  • Mass (Da)
    41,561
  • Last updated
    2001-12-01 v1
  • MD5 Checksum
    FFF827FDA413CDBFB4839991D4DC14F0
MEAVLVAMSVPATTEDDGFSLITDKLSYNLTPTSDVEIVTSDNRRIPAHSGVLASASPVLMNIMKKPMRRYRGCGSKRVIKILGVPCDAVSVFIKFLYSSSLTEDEMERYGIHLLALSHVYMVTQLKQRCSKGVVQRLTTENVVDVLQLARLCDAPDVCLRSMRLIHSQFKTVEQTEGWKFIQEHDPFLELDILQFIDDAESRKKRRRRHRKEQDLYMQLSEAMECIEHICTQGCTLVGPSNVVDNNKKSMTAEKSEPCKAFSTCYGLQLLIRHFAVCKRRNNDKGCLRCKRMLQLFRLHSLICDQPDSCRVPLCRQFRKRGEQDKKMGEDTKWKLLVTRVVSAKAMTSLCQSKKNKCEQAQGV

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1I9LNB7A0A1I9LNB7_ARATHBT2258
A0A1I9LNB8A0A1I9LNB8_ARATHBT2334

Sequence caution

The sequence CAB41162.1 differs from that shown. Reason: Erroneous gene model prediction

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY316675
EMBL· GenBank· DDBJ
AAQ87005.1
EMBL· GenBank· DDBJ
mRNA
AL049659
EMBL· GenBank· DDBJ
CAB41162.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
CP002686
EMBL· GenBank· DDBJ
AEE78407.1
EMBL· GenBank· DDBJ
Genomic DNA
AY040015
EMBL· GenBank· DDBJ
AAK64172.1
EMBL· GenBank· DDBJ
mRNA
AY079408
EMBL· GenBank· DDBJ
AAL85139.1
EMBL· GenBank· DDBJ
mRNA
BT000678
EMBL· GenBank· DDBJ
AAN31824.1
EMBL· GenBank· DDBJ
mRNA
AK226596
EMBL· GenBank· DDBJ
BAE98711.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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