Q94BN0 · BT2_ARATH
- ProteinBTB/POZ and TAZ domain-containing protein 2
- GeneBT2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids364 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Plays a key role as a component of the TAC1-mediated telomerase activation pathway certainly by targeting a telomerase repressor to degradation. Seems to occupy an integral position in a complex signaling network that perceives, integrates, and responds to multiple, and sometimes competing, signals. Enhances responses to auxin in postgermination and vegetative development. Also negatively regulates ABA- and sugar-mediated inhibition of the germination. Essential for female and male gametophyte development.
Pathway
Protein modification; protein ubiquitination.
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | calmodulin binding | |
Molecular Function | metal ion binding | |
Biological Process | abscisic acid-activated signaling pathway | |
Biological Process | auxin-activated signaling pathway | |
Biological Process | circadian rhythm | |
Biological Process | embryo sac development | |
Biological Process | pollen development | |
Biological Process | protein ubiquitination | |
Biological Process | regulation of DNA-templated transcription | |
Biological Process | response to abscisic acid | |
Biological Process | response to auxin | |
Biological Process | response to carbohydrate | |
Biological Process | response to cold | |
Biological Process | response to hydrogen peroxide | |
Biological Process | response to jasmonic acid | |
Biological Process | response to nitrate | |
Biological Process | response to salicylic acid | |
Biological Process | response to salt stress | |
Biological Process | response to wounding | |
Biological Process | sugar mediated signaling pathway |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBTB/POZ and TAZ domain-containing protein 2
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ94BN0
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Phenotypes & Variants
Disruption phenotype
Altered response to auxin. Blocked ability of TAC1 to induce telomerase. Hypersensitive response to both sugar and abscisic acid (ABA)-mediated inhibition of germination.
Variants
![](/variants.8e7f84.jpg)
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 56 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000406143 | 1-364 | BTB/POZ and TAZ domain-containing protein 2 | ||
Proteomic databases
Expression
Tissue specificity
Preferentially expressed in young leaves and roots.
Induction
Up-regulated by auxin (IAA), methyl jasmonate (MeJA), hydrogen peroxide and nitrates. Down-regulated by salicylic acid (SA), abscisic acid (ABA), hydrogen peroxide, sugars, cold and NaCl. Positively regulated by the transcriptional factor TAC1. Circadian-regulation; expression increase during the dark phase and decrease during the light phase.
Gene expression databases
Interaction
Subunit
Interacts with CUL3A. Interacts with GTE11/BET10 through the BTB domain.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | IntAct | |
---|---|---|---|---|---|
BINARY | Q94BN0 | CPK11 Q39016 | 7 | EBI-540986, EBI-979321 | |
BINARY | Q94BN0 | CPK4 Q38869 | 7 | EBI-540986, EBI-979475 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, motif, zinc finger, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 34-106 | BTB | |||
Motif | 203-212 | Nuclear localization signal | |||
Zinc finger | 215-316 | TAZ-type | |||
Region | 327-350 | CaM-binding | |||
Domain
The BTB/POZ domain mediates the interaction with some component of ubiquitin ligase complexes.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length364
- Mass (Da)41,561
- Last updated2001-12-01 v1
- MD5 ChecksumFFF827FDA413CDBFB4839991D4DC14F0
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A1I9LNB7 | A0A1I9LNB7_ARATH | BT2 | 258 | ||
A0A1I9LNB8 | A0A1I9LNB8_ARATH | BT2 | 334 |
Sequence caution
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY316675 EMBL· GenBank· DDBJ | AAQ87005.1 EMBL· GenBank· DDBJ | mRNA | ||
AL049659 EMBL· GenBank· DDBJ | CAB41162.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
CP002686 EMBL· GenBank· DDBJ | AEE78407.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY040015 EMBL· GenBank· DDBJ | AAK64172.1 EMBL· GenBank· DDBJ | mRNA | ||
AY079408 EMBL· GenBank· DDBJ | AAL85139.1 EMBL· GenBank· DDBJ | mRNA | ||
BT000678 EMBL· GenBank· DDBJ | AAN31824.1 EMBL· GenBank· DDBJ | mRNA | ||
AK226596 EMBL· GenBank· DDBJ | BAE98711.1 EMBL· GenBank· DDBJ | mRNA |