Q949N0 · NAC53_ARATH

Function

function

Transcriptional activator activated by proteolytic cleavage through regulated intramembrane proteolysis (RIP) (PubMed:24323506, PubMed:25219309, Ref.6). Promotes reactive oxygen species (ROS) production during drought-induced leaf senescence. In response to abscisic acid (ABA)-mediated drought stress signals, binds directly to the promoters of RBOHC and RBOHE genes, encoding ROS biosynthetic enzymes, resulting in ROS accumulation and triggering leaf senescence via programmed cell death (PCD). ROS-induced leaf senescence sustains plant survival under drought conditions (PubMed:22313226).
Involved in heat stress response. Modulates PCD through a ROS-mediated positive feedback control under heat stress conditions. This may provide an adaptation strategy for plant survival under extreme heat stress conditions (PubMed:25219309).
Acts as a repressor in preventing anther dehiscence during stamen development by suppressing genes that participate in jasmonic acid (JA) biosynthesis, such as DAD1, AOS, AOC3, OPR3 and 4CLL5/OPCL1 (PubMed:24323506).

Features

Showing features for dna binding.

154950100150200250300350400450500
TypeIDPosition(s)Description
DNA binding108-165

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentendoplasmic reticulum membrane
Cellular Componentnucleus
Molecular FunctionDNA-binding transcription factor activity
Molecular Functiontranscription cis-regulatory region binding
Biological Processdrought recovery
Biological Processleaf senescence
Biological Processpositive regulation of DNA-templated transcription
Biological Processregulation of reactive oxygen species metabolic process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    NAC domain-containing protein 53
  • Short names
    ANAC053
  • Alternative names
    • Protein ANTHER INDEHISCENCE FACTOR
    • Protein NTM1-like 4

Gene names

    • Name
      NAC053
    • Synonyms
      AIF
      , NTL4
    • ORF names
      F13M14.22
      , F18K10.7
    • Ordered locus names
      At3g10500

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q949N0
  • Secondary accessions
    • Q8LAH6
    • Q9SQY1

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Endoplasmic reticulum membrane
; Single-pass membrane protein
Nucleus
Note: Localized primarily in plasma membrane or endoplasmic reticulum membrane as dormant form and, upon abiotic stress, is processed into a transcriptionally active and nuclear form after a proteolytic cleavage through regulated intramembrane proteolysis (RIP).

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane526-546Helical

Keywords

Phenotypes & Variants

Disruption phenotype

Delayed leaf senescence and enhanced drought resistance (PubMed:22313226).
Enhanced heat resistance (PubMed:25219309).

Variants

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The viewer provides 44 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004324441-549NAC domain-containing protein 53

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in roots, rosette leaves, cauline leaves, shoot apex and stems.

Induction

By abscisic acid (ABA) (PubMed:22313226, PubMed:25219309).
Induced by heat shock (PubMed:25219309).
Induced by cold, drought stress and methyl methanesulfonate (MMS) treatment (PubMed:17158162).

Developmental stage

Expressed in the anthers and the upper parts of the stamen filaments after stage 7 to 9 of flower budding. In stage 10 flower buds, expressed in the anthers and pollen grains. Weakly expressed in mature flowers at stage 12.

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain9-159NAC
Region395-418Disordered

Domain

The NAC domain includes a DNA binding domain and a dimerization domain.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    549
  • Mass (Da)
    62,356
  • Last updated
    2001-12-01 v1
  • MD5 Checksum
    8BD010ED9BDACD4D33BC22DC222D7206
MGRGSVTSLAPGFRFHPTDEELVRYYLKRKICNKPFKFDAISVTDVYKSEPWDLPDKSRLKSRDLEWYFFSMLDKKYRNGSKTNRATEMGYWKTTGKDREILNGSKVVGMKKTLVYHKGRAPRGERTNWVMHEYRLVDQDLDKTGVHQDAFVLCRIFQKSGSGPKNGEQYGAPFVEEEWEEEDDMTFVPDQEDLGSEDHVYVHMDDIDQKSENFVVYDAIPIPLNFIHGESSNNVETNYSDSINYIQQTGNYMDSGGYFEQPAESYEKDQKPIIRDRDGSLQNEGIGCGVQDKHSETLQSSDNIFGTDTSCYNDFPVESNYLIGEAFLDPNSNLLENDGLYLETNDLSSTQQDGFDFEDYLTFFDETFDPSQLMGNEDVFFDQEELFQEVETKELEKEETSRSKHVVEEKEKDEASCSKQVDADATEFEPDYKYPLLKKASHMLGAIPAPLANASEFPTKDAAIRLHAAQSSGSVHVTAGMITISDSNMGWSYGKNENLDLILSLGLVQGNTAPEKSGNSSAWAMLIFMCFWVLLLSVSFKVSILVSSR

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1I9LN95A0A1I9LN95_ARATHNAC053415

Sequence caution

The sequence AAF76351.1 differs from that shown. Reason: Erroneous gene model prediction
The sequence AAG51388.1 differs from that shown. Reason: Erroneous gene model prediction

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict74in Ref. 4; AAM65338
Sequence conflict276in Ref. 4; AAM65338
Sequence conflict297in Ref. 4; AAM65338

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC011560
EMBL· GenBank· DDBJ
AAG51388.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
AC013428
EMBL· GenBank· DDBJ
AAF76351.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
CP002686
EMBL· GenBank· DDBJ
AEE74917.1
EMBL· GenBank· DDBJ
Genomic DNA
AY051003
EMBL· GenBank· DDBJ
AAK93680.1
EMBL· GenBank· DDBJ
mRNA
AY079345
EMBL· GenBank· DDBJ
AAL85076.1
EMBL· GenBank· DDBJ
mRNA
AY087802
EMBL· GenBank· DDBJ
AAM65338.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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