Q94901 · LARK_DROME

Function

function

Essential RNA-binding protein. May be required for circadian repression of eclosion. Also essential for nurse cell dumping during oogenesis, the process whereby the cytoplasmic contents of nurse cells are transferred to the oocyte late in it's development.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcatalytic step 2 spliceosome
Cellular Componentcytoplasm
Cellular Componentnuclear speck
Cellular Componentnucleus
Cellular Componentprecatalytic spliceosome
Molecular FunctionmRNA binding
Molecular FunctionRNA binding
Molecular Functionzinc ion binding
Biological Processactin cytoskeleton organization
Biological Processcircadian rhythm
Biological Processeclosion
Biological Processeclosion rhythm
Biological Processembryo development ending in birth or egg hatching
Biological Processlocomotor rhythm
Biological Processmitotic cell cycle
Biological ProcessmRNA splicing, via spliceosome
Biological Processnegative regulation of eclosion
Biological Processovarian nurse cell to oocyte transport
Biological Processpositive regulation of cytoplasmic translation
Biological Processprotein localization
Biological Processregulation of circadian rhythm
Biological Processregulation of embryonic development

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    RNA-binding protein lark

Gene names

    • Name
      lark
    • ORF names
      CG8597

Organism names

  • Taxonomic identifier
  • Strain
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    Q94901
  • Secondary accessions
    • A4V1L0

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasm
Nucleus
Note: The precise location within neurons varies according to the type of neuron, being cytoplasmic in CCAP neurons and nuclear in the CNS.

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis10Non-functional; when associated with A-89.
Mutagenesis89Defects in sensory bristle formation and wing shape, and oogenesis. Non-functional; when associated with A-10.
Mutagenesis170Defects in sensory bristle formation and wing shape, and oogenesis; when associated with Y-173.
Mutagenesis173Defects in sensory bristle formation and wing shape, and oogenesis; when associated with Y-170.

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00000817581-352RNA-binding protein lark
Modified residue198Phosphoserine
Modified residue201Phosphoserine
Modified residue315Phosphoserine
Modified residue325Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in the CNS and in CCAP neurons of the ventral nervous system (VNS), which control insect ecdysis.

Induction

Oscillates in abundance during the circadian cycle at the protein level; peaks during the subjective day.

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, zinc finger, region, compositional bias.

TypeIDPosition(s)Description
Domain7-77RRM 1
Domain86-156RRM 2
Zinc finger168-185CCHC-type
Region187-228Disordered
Compositional bias212-226Pro residues
Region254-352Disordered
Compositional bias280-314Polar residues

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    352
  • Mass (Da)
    39,912
  • Last updated
    1997-02-01 v1
  • Checksum
    C8D698D4DD122FA9
MPGAGTFKLFIGNLDEKTQATELRALFEKYGTVVECDVVKNYGFVHMETEQQGRDAIQNLNGYTLNEFAIKVEAAKSRRAPNTPTTKIFVGNLTDKTRAPEVRELFQKYGTVVECDIVRNYGFVHLDCVGDVQDAIKELNGRVVDGQPLKVQVSTSRVRPKPGMGDPEQCYRCGRSGHWSKECPRLYGSAGGGREPPSPLSAGGYRDRMYGRDPYPPPPPPPPFLRDRIMDGFRDYDYYDRRFEDSRDLYERRYQTSRMRDFPPPPISRREPMPLPPTLSGSLRSCSVSRGYDTMFSRRSPPPPRSSNGMSRYGSPTPHGYEDFSRDAFDERMISSRGMRGPSPPGRRYAPY

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias212-226Pro residues
Compositional bias280-314Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U59476
EMBL· GenBank· DDBJ
AAB07067.1
EMBL· GenBank· DDBJ
mRNA
AE014296
EMBL· GenBank· DDBJ
AAF50578.1
EMBL· GenBank· DDBJ
Genomic DNA
AE014296
EMBL· GenBank· DDBJ
AAN12053.1
EMBL· GenBank· DDBJ
Genomic DNA
AE014296
EMBL· GenBank· DDBJ
AAN12054.1
EMBL· GenBank· DDBJ
Genomic DNA
AE014296
EMBL· GenBank· DDBJ
AAN12055.1
EMBL· GenBank· DDBJ
Genomic DNA
AE014296
EMBL· GenBank· DDBJ
AAN12056.1
EMBL· GenBank· DDBJ
Genomic DNA
AY061458
EMBL· GenBank· DDBJ
AAL29006.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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