Q94901 · LARK_DROME
- ProteinRNA-binding protein lark
- Genelark
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids352 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Essential RNA-binding protein. May be required for circadian repression of eclosion. Also essential for nurse cell dumping during oogenesis, the process whereby the cytoplasmic contents of nurse cells are transferred to the oocyte late in it's development.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | catalytic step 2 spliceosome | |
Cellular Component | cytoplasm | |
Cellular Component | nuclear speck | |
Cellular Component | nucleus | |
Cellular Component | precatalytic spliceosome | |
Molecular Function | mRNA binding | |
Molecular Function | RNA binding | |
Molecular Function | zinc ion binding | |
Biological Process | actin cytoskeleton organization | |
Biological Process | circadian rhythm | |
Biological Process | eclosion | |
Biological Process | eclosion rhythm | |
Biological Process | embryo development ending in birth or egg hatching | |
Biological Process | locomotor rhythm | |
Biological Process | mitotic cell cycle | |
Biological Process | mRNA splicing, via spliceosome | |
Biological Process | negative regulation of eclosion | |
Biological Process | ovarian nurse cell to oocyte transport | |
Biological Process | positive regulation of cytoplasmic translation | |
Biological Process | protein localization | |
Biological Process | regulation of circadian rhythm | |
Biological Process | regulation of embryonic development |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRNA-binding protein lark
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ94901
- Secondary accessions
Proteomes
Organism-specific databases
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 10 | Non-functional; when associated with A-89. | ||||
Sequence: F → A | ||||||
Mutagenesis | 89 | Defects in sensory bristle formation and wing shape, and oogenesis. Non-functional; when associated with A-10. | ||||
Sequence: F → A | ||||||
Mutagenesis | 170 | Defects in sensory bristle formation and wing shape, and oogenesis; when associated with Y-173. | ||||
Sequence: C → Y | ||||||
Mutagenesis | 173 | Defects in sensory bristle formation and wing shape, and oogenesis; when associated with Y-170. | ||||
Sequence: C → Y |
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000081758 | 1-352 | RNA-binding protein lark | |||
Sequence: MPGAGTFKLFIGNLDEKTQATELRALFEKYGTVVECDVVKNYGFVHMETEQQGRDAIQNLNGYTLNEFAIKVEAAKSRRAPNTPTTKIFVGNLTDKTRAPEVRELFQKYGTVVECDIVRNYGFVHLDCVGDVQDAIKELNGRVVDGQPLKVQVSTSRVRPKPGMGDPEQCYRCGRSGHWSKECPRLYGSAGGGREPPSPLSAGGYRDRMYGRDPYPPPPPPPPFLRDRIMDGFRDYDYYDRRFEDSRDLYERRYQTSRMRDFPPPPISRREPMPLPPTLSGSLRSCSVSRGYDTMFSRRSPPPPRSSNGMSRYGSPTPHGYEDFSRDAFDERMISSRGMRGPSPPGRRYAPY | ||||||
Modified residue | 198 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 201 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 315 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 325 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in the CNS and in CCAP neurons of the ventral nervous system (VNS), which control insect ecdysis.
Induction
Oscillates in abundance during the circadian cycle at the protein level; peaks during the subjective day.
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, zinc finger, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 7-77 | RRM 1 | ||||
Sequence: FKLFIGNLDEKTQATELRALFEKYGTVVECDVVKNYGFVHMETEQQGRDAIQNLNGYTLNEFAIKVEAAKS | ||||||
Domain | 86-156 | RRM 2 | ||||
Sequence: TKIFVGNLTDKTRAPEVRELFQKYGTVVECDIVRNYGFVHLDCVGDVQDAIKELNGRVVDGQPLKVQVSTS | ||||||
Zinc finger | 168-185 | CCHC-type | ||||
Sequence: EQCYRCGRSGHWSKECPR | ||||||
Region | 187-228 | Disordered | ||||
Sequence: YGSAGGGREPPSPLSAGGYRDRMYGRDPYPPPPPPPPFLRDR | ||||||
Compositional bias | 212-226 | Pro residues | ||||
Sequence: RDPYPPPPPPPPFLR | ||||||
Region | 254-352 | Disordered | ||||
Sequence: YQTSRMRDFPPPPISRREPMPLPPTLSGSLRSCSVSRGYDTMFSRRSPPPPRSSNGMSRYGSPTPHGYEDFSRDAFDERMISSRGMRGPSPPGRRYAPY | ||||||
Compositional bias | 280-314 | Polar residues | ||||
Sequence: SGSLRSCSVSRGYDTMFSRRSPPPPRSSNGMSRYG |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length352
- Mass (Da)39,912
- Last updated1997-02-01 v1
- ChecksumC8D698D4DD122FA9
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 212-226 | Pro residues | ||||
Sequence: RDPYPPPPPPPPFLR | ||||||
Compositional bias | 280-314 | Polar residues | ||||
Sequence: SGSLRSCSVSRGYDTMFSRRSPPPPRSSNGMSRYG |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U59476 EMBL· GenBank· DDBJ | AAB07067.1 EMBL· GenBank· DDBJ | mRNA | ||
AE014296 EMBL· GenBank· DDBJ | AAF50578.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014296 EMBL· GenBank· DDBJ | AAN12053.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014296 EMBL· GenBank· DDBJ | AAN12054.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014296 EMBL· GenBank· DDBJ | AAN12055.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014296 EMBL· GenBank· DDBJ | AAN12056.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY061458 EMBL· GenBank· DDBJ | AAL29006.1 EMBL· GenBank· DDBJ | mRNA |