Q94823 · LICI3_TACTR
- ProteinIntracellular coagulation inhibitor 3
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids414 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Serine protease inhibitor that inhibits clotting factor G and to a lesser extent proclotting enzyme and clotting factor C.
Features
Showing features for site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 381-382 | Reactive bond | ||||
Sequence: RS |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular space | |
Molecular Function | serine-type endopeptidase inhibitor activity | |
Biological Process | negative regulation of serine-type endopeptidase activity |
Keywords
- Molecular function
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameIntracellular coagulation inhibitor 3
- Alternative names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Chelicerata > Merostomata > Xiphosura > Limulidae > Tachypleus
Accessions
- Primary accessionQ94823
Subcellular Location
UniProt Annotation
GO Annotation
Note: Localizes in the large granules of hemocytes (By similarity).
Secreted in hemolymph in response to external stimuli (By similarity).
Secreted in hemolymph in response to external stimuli (By similarity).
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-22 | |||||
Sequence: MKTLIFTLSSLQLIFLPQLSLG | ||||||
Chain | PRO_5004322072 | 23-414 | Intracellular coagulation inhibitor 3 | |||
Sequence: NYLLDEILHLSDVDQQQLSAVTRITNASNYFGFDLYNTLKGSGNVLISPYSLSCAMAMVYLGSRGVTEREMHSVLNYGSFGLTRDDVRLGFQQAINTLTSNTIGYTLDTANALLIQRSFEVQEDFRQKIETDFGAEVREVDFQSQTTIVQQAINTWTAHKTQNNIQNILKEPPDSNTLLFFLNAVYFKGFWETTFDPKQSTIMKFYNNGSVSTDTVMMMMESRLPFGYVESLNCLALEMPYQGRNVTMLLLLPVSPNGLPELEQALSPASISLIYSTLRKRRVKVFIPKFKLEEEYEEVLKEGLSDMGMKSLFGFNANLNGITEDTGLYVTTVVHKTSIEVDEEGTVASAASGVGGGWRSATPRFMANHPFLFFIRHSETGAVLFMGRVSQL | ||||||
Glycosylation | 48 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 230 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 267 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Post-translational modification
N-glycosylated.
Keywords
- PTM
Expression
Tissue specificity
Specifically expressed in hemocytes (at protein level).
Structure
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length414
- Mass (Da)46,394
- Last updated1997-02-01 v1
- ChecksumB9512303D6AAAF39
Keywords
- Technical term