Q94823 · LICI3_TACTR

Function

function

Serine protease inhibitor that inhibits clotting factor G and to a lesser extent proclotting enzyme and clotting factor C.

Features

Showing features for site.

141450100150200250300350400
TypeIDPosition(s)Description
Site381-382Reactive bond

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular space
Molecular Functionserine-type endopeptidase inhibitor activity
Biological Processnegative regulation of serine-type endopeptidase activity

Keywords

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Intracellular coagulation inhibitor 3
  • Alternative names
    • Limulus intracellular coagulation inhibitor 3
      (LICI-3
      )

Organism names

Accessions

  • Primary accession
    Q94823

Subcellular Location

Secreted
Note: Localizes in the large granules of hemocytes (By similarity).
Secreted in hemolymph in response to external stimuli (By similarity).

Keywords

PTM/Processing

Features

Showing features for signal, chain, glycosylation.

TypeIDPosition(s)Description
Signal1-22
ChainPRO_500432207223-414Intracellular coagulation inhibitor 3
Glycosylation48N-linked (GlcNAc...) asparagine
Glycosylation230N-linked (GlcNAc...) asparagine
Glycosylation267N-linked (GlcNAc...) asparagine

Post-translational modification

N-glycosylated.

Keywords

Expression

Tissue specificity

Specifically expressed in hemocytes (at protein level).

Interaction

Subunit

Monomer (PubMed:8798603).
Forms a covalent heterodimer with clotting factor G subunit beta chain B (PubMed:8798603).

Structure

Family & Domains

Sequence similarities

Belongs to the serpin family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    414
  • Mass (Da)
    46,394
  • Last updated
    1997-02-01 v1
  • Checksum
    B9512303D6AAAF39
MKTLIFTLSSLQLIFLPQLSLGNYLLDEILHLSDVDQQQLSAVTRITNASNYFGFDLYNTLKGSGNVLISPYSLSCAMAMVYLGSRGVTEREMHSVLNYGSFGLTRDDVRLGFQQAINTLTSNTIGYTLDTANALLIQRSFEVQEDFRQKIETDFGAEVREVDFQSQTTIVQQAINTWTAHKTQNNIQNILKEPPDSNTLLFFLNAVYFKGFWETTFDPKQSTIMKFYNNGSVSTDTVMMMMESRLPFGYVESLNCLALEMPYQGRNVTMLLLLPVSPNGLPELEQALSPASISLIYSTLRKRRVKVFIPKFKLEEEYEEVLKEGLSDMGMKSLFGFNANLNGITEDTGLYVTTVVHKTSIEVDEEGTVASAASGVGGGWRSATPRFMANHPFLFFIRHSETGAVLFMGRVSQL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
D85341
EMBL· GenBank· DDBJ
BAA12795.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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