Q945F0 · DTX47_ARATH
- ProteinProtein DETOXIFICATION 47, chloroplastic
- GeneDTX47
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids543 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Functions as a multidrug and toxin extrusion transporter in the export of salicylic acid (SA) from the chloroplast to the cytoplasm (PubMed:23757404).
Plays an essential function in plant defense via the pathogen-induced salicylic acid (SA) accumulation (PubMed:11826312, PubMed:24594657).
Acts also as a key component of the Age-related resistance (ARR) pathway (PubMed:11884688, PubMed:19694953, PubMed:24594657).
Plays an essential function in plant defense via the pathogen-induced salicylic acid (SA) accumulation (PubMed:11826312, PubMed:24594657).
Acts also as a key component of the Age-related resistance (ARR) pathway (PubMed:11884688, PubMed:19694953, PubMed:24594657).
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | chloroplast envelope | |
Cellular Component | chloroplast membrane | |
Cellular Component | plastid | |
Molecular Function | antiporter activity | |
Molecular Function | xenobiotic transmembrane transporter activity | |
Biological Process | defense response | |
Biological Process | defense response to bacterium | |
Biological Process | innate immune response | |
Biological Process | negative regulation of defense response | |
Biological Process | response to nematode | |
Biological Process | response to salicylic acid | |
Biological Process | salicylic acid biosynthetic process |
Keywords
- Biological process
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameProtein DETOXIFICATION 47, chloroplastic
- Short namesAtDTX47
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ945F0
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
Plastid, chloroplast membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 107-127 | Helical | ||||
Sequence: GPAMGMWICGPLMSLIDTVVI | ||||||
Transmembrane | 135-155 | Helical | ||||
Sequence: LAALGPGTVLCDHMSYVFMFL | ||||||
Transmembrane | 181-201 | Helical | ||||
Sequence: VLLFIGLVCGLMMLLLTRLFG | ||||||
Transmembrane | 228-248 | Helical | ||||
Sequence: GLAWPFILVGLVAQSASLGMK | ||||||
Transmembrane | 256-276 | Helical | ||||
Sequence: ALAAATIINGLGDTILCLFLG | ||||||
Transmembrane | 278-298 | Helical | ||||
Sequence: GIAGAAWATTASQIVSAYMMM | ||||||
Transmembrane | 319-339 | Helical | ||||
Sequence: LWKISALAAPVFISIFSKIAF | ||||||
Transmembrane | 342-362 | Helical | ||||
Sequence: FIIYCATSMGTHVLAAHQVMA | ||||||
Transmembrane | 406-426 | Helical | ||||
Sequence: IIGATLGLVLGVIGTAVPGLF | ||||||
Transmembrane | 443-463 | Helical | ||||
Sequence: LLIPFFMALSALPMTVSLEGT | ||||||
Transmembrane | 472-492 | Helical | ||||
Sequence: FVSSVMSSSFIIGCLTLMFVT | ||||||
Transmembrane | 497-517 | Helical | ||||
Sequence: GLLGCWFVLVGFQWGRFGLYL |
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Enhanced susceptibility to several bacterial pathogens and alterations in PR-1 gene expression (PubMed:9090877).
No salicylic acid (SA) accumulation after pathogen inoculation and more susceptibility to both virulent and avirulent forms of Pseudomonas syringae and Peronospora parasitica (PubMed:10449575, PubMed:24594657).
Age-related resistance (ARR)-defective (PubMed:11884688, PubMed:19694953).
Defect in stomatal response during bacterial infection (PubMed:21998587).
No salicylic acid (SA) accumulation after pathogen inoculation and more susceptibility to both virulent and avirulent forms of Pseudomonas syringae and Peronospora parasitica (PubMed:10449575, PubMed:24594657).
Age-related resistance (ARR)-defective (PubMed:11884688, PubMed:19694953).
Defect in stomatal response during bacterial infection (PubMed:21998587).
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 41 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for transit peptide, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transit peptide | 1-30 | Chloroplast | ||||
Sequence: MLIKSQRLTLFSPLLSKTRRIPVNSHQTLV | ||||||
Chain | PRO_0000164259 | 31-543 | Protein DETOXIFICATION 47, chloroplastic | |||
Sequence: AESVITRRTLGAITATPSFHKNPVVIRRRIKLERVTRNCVRIDREIDEEEEEEEKERGDLVKQSIWEQMKEIVKFTGPAMGMWICGPLMSLIDTVVIGQGSSIELAALGPGTVLCDHMSYVFMFLSVATSNMVATSLAKQDKKEAQHQISVLLFIGLVCGLMMLLLTRLFGPWAVTAFTRGKNIEIVPAANKYIQIRGLAWPFILVGLVAQSASLGMKNSWGPLKALAAATIINGLGDTILCLFLGQGIAGAAWATTASQIVSAYMMMDSLNKEGYNAYSFAIPSPQELWKISALAAPVFISIFSKIAFYSFIIYCATSMGTHVLAAHQVMAQTYRMCNVWGEPLSQTAQSFMPEMLYGANRNLPKARTLLKSLMIIGATLGLVLGVIGTAVPGLFPGVYTHDKVIISEMHRLLIPFFMALSALPMTVSLEGTLLAGRDLKFVSSVMSSSFIIGCLTLMFVTRSGYGLLGCWFVLVGFQWGRFGLYLRRLLSPGGILNSDGPSPYTVEKIKSI |
Proteomic databases
PTM databases
Expression
Tissue specificity
Preferentially expressed in the epidermal cells.
Induction
By salicylic acid, UV-C light and pathogens.
Gene expression databases
Structure
Family & Domains
Features
Showing features for coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Coiled coil | 55-94 | |||||
Sequence: VIRRRIKLERVTRNCVRIDREIDEEEEEEEKERGDLVKQS |
Sequence similarities
Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length543
- Mass (Da)59,528
- Last updated2001-12-01 v1
- ChecksumDF2EEFE0942A51C5
Sequence caution
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF416569 EMBL· GenBank· DDBJ | AAL27003.1 EMBL· GenBank· DDBJ | mRNA | ||
AL035679 EMBL· GenBank· DDBJ | CAB38823.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
AL161594 EMBL· GenBank· DDBJ | CAB80566.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
CP002687 EMBL· GenBank· DDBJ | AEE87009.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AK175482 EMBL· GenBank· DDBJ | BAD43245.1 EMBL· GenBank· DDBJ | mRNA | ||
AK176074 EMBL· GenBank· DDBJ | BAD43837.1 EMBL· GenBank· DDBJ | mRNA | ||
AK176272 EMBL· GenBank· DDBJ | BAD44035.1 EMBL· GenBank· DDBJ | mRNA | ||
AK176334 EMBL· GenBank· DDBJ | BAD44097.1 EMBL· GenBank· DDBJ | mRNA |