Q945F0 · DTX47_ARATH

Function

function

Functions as a multidrug and toxin extrusion transporter in the export of salicylic acid (SA) from the chloroplast to the cytoplasm (PubMed:23757404).
Plays an essential function in plant defense via the pathogen-induced salicylic acid (SA) accumulation (PubMed:11826312, PubMed:24594657).
Acts also as a key component of the Age-related resistance (ARR) pathway (PubMed:11884688, PubMed:19694953, PubMed:24594657).

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchloroplast envelope
Cellular Componentchloroplast membrane
Cellular Componentplastid
Molecular Functionantiporter activity
Molecular Functionxenobiotic transmembrane transporter activity
Biological Processdefense response
Biological Processdefense response to bacterium
Biological Processinnate immune response
Biological Processnegative regulation of defense response
Biological Processresponse to nematode
Biological Processresponse to salicylic acid
Biological Processsalicylic acid biosynthetic process

Keywords

Protein family/group databases

    • 2.A.66.1.11the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily

Names & Taxonomy

Protein names

  • Recommended name
    Protein DETOXIFICATION 47, chloroplastic
  • Short names
    AtDTX47
  • Alternative names
    • Multidrug and toxic compound extrusion protein 47
      (MATE protein 47
      )
    • Protein ENHANCED DISEASE SUSCEPTIBILITY 5
      (Protein EDS5
      )
    • Protein IMPORTANT FOR THE ARR PATHWAY 1
      (Protein IAP1
      )
    • Protein SALICYLIC ACID INDUCTION DEFICIENT 1
      (Protein SID1
      )
    • Protein SUSCEPTIBLE TO CORONATINE-DEFICIENT PST DC3000 3 (Protein SCORD3
      )

Gene names

    • Name
      DTX47
    • Synonyms
      EDS5
      , IAP1
      , SCORD3
      , SID1
    • ORF names
      F19H22.130
    • Ordered locus names
      At4g39030

Organism names

  • Taxonomic identifier
  • Strains
    • cv. Columbia
    • cv. Landsberg erecta
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q945F0
  • Secondary accessions
    • Q67ZP3
    • Q9SVJ0

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane107-127Helical
Transmembrane135-155Helical
Transmembrane181-201Helical
Transmembrane228-248Helical
Transmembrane256-276Helical
Transmembrane278-298Helical
Transmembrane319-339Helical
Transmembrane342-362Helical
Transmembrane406-426Helical
Transmembrane443-463Helical
Transmembrane472-492Helical
Transmembrane497-517Helical

Keywords

Phenotypes & Variants

Disruption phenotype

Enhanced susceptibility to several bacterial pathogens and alterations in PR-1 gene expression (PubMed:9090877).
No salicylic acid (SA) accumulation after pathogen inoculation and more susceptibility to both virulent and avirulent forms of Pseudomonas syringae and Peronospora parasitica (PubMed:10449575, PubMed:24594657).
Age-related resistance (ARR)-defective (PubMed:11884688, PubMed:19694953).
Defect in stomatal response during bacterial infection (PubMed:21998587).

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 41 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for transit peptide, chain.

TypeIDPosition(s)Description
Transit peptide1-30Chloroplast
ChainPRO_000016425931-543Protein DETOXIFICATION 47, chloroplastic

Proteomic databases

PTM databases

Expression

Tissue specificity

Preferentially expressed in the epidermal cells.

Induction

By salicylic acid, UV-C light and pathogens.

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for coiled coil.

TypeIDPosition(s)Description
Coiled coil55-94

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    543
  • Mass (Da)
    59,528
  • Last updated
    2001-12-01 v1
  • Checksum
    DF2EEFE0942A51C5
MLIKSQRLTLFSPLLSKTRRIPVNSHQTLVAESVITRRTLGAITATPSFHKNPVVIRRRIKLERVTRNCVRIDREIDEEEEEEEKERGDLVKQSIWEQMKEIVKFTGPAMGMWICGPLMSLIDTVVIGQGSSIELAALGPGTVLCDHMSYVFMFLSVATSNMVATSLAKQDKKEAQHQISVLLFIGLVCGLMMLLLTRLFGPWAVTAFTRGKNIEIVPAANKYIQIRGLAWPFILVGLVAQSASLGMKNSWGPLKALAAATIINGLGDTILCLFLGQGIAGAAWATTASQIVSAYMMMDSLNKEGYNAYSFAIPSPQELWKISALAAPVFISIFSKIAFYSFIIYCATSMGTHVLAAHQVMAQTYRMCNVWGEPLSQTAQSFMPEMLYGANRNLPKARTLLKSLMIIGATLGLVLGVIGTAVPGLFPGVYTHDKVIISEMHRLLIPFFMALSALPMTVSLEGTLLAGRDLKFVSSVMSSSFIIGCLTLMFVTRSGYGLLGCWFVLVGFQWGRFGLYLRRLLSPGGILNSDGPSPYTVEKIKSI

Sequence caution

The sequence CAB38823.1 differs from that shown. Reason: Erroneous gene model prediction
The sequence CAB80566.1 differs from that shown. Reason: Erroneous gene model prediction

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF416569
EMBL· GenBank· DDBJ
AAL27003.1
EMBL· GenBank· DDBJ
mRNA
AL035679
EMBL· GenBank· DDBJ
CAB38823.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
AL161594
EMBL· GenBank· DDBJ
CAB80566.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
CP002687
EMBL· GenBank· DDBJ
AEE87009.1
EMBL· GenBank· DDBJ
Genomic DNA
AK175482
EMBL· GenBank· DDBJ
BAD43245.1
EMBL· GenBank· DDBJ
mRNA
AK176074
EMBL· GenBank· DDBJ
BAD43837.1
EMBL· GenBank· DDBJ
mRNA
AK176272
EMBL· GenBank· DDBJ
BAD44035.1
EMBL· GenBank· DDBJ
mRNA
AK176334
EMBL· GenBank· DDBJ
BAD44097.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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