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Q94515 · DEGS1_DROME

Function

function

Has sphingolipid-delta-4-desaturase activity. Converts sphinganine-containing sphingolipids (such as N-acylsphinganines or dihydroceramides) into sphingolipids containing the delta-4-desaturated sphingoid base (E)-sphing-4-enine (such as N-acylsphing-4-enines or ceramides), which are required for many different functions (structural functions as well as signaling) (PubMed:11937514).
Required to initiate spermatid differentiation among other signals (PubMed:9003299).
Required for central spindle assembly and cytokinesis during male meiosis, may act as part of an anchoring mechanism that links membrane-bounded cellular compartments to components of the cytoskeleton (PubMed:9819060).

Catalytic activity

Pathway

Sphingolipid metabolism.

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum
Cellular Componentendoplasmic reticulum membrane
Cellular Componentlate endosome
Cellular Componentmitochondrion
Molecular Functionsphingolipid delta-4 desaturase activity
Biological Processceramide biosynthetic process
Biological Processnegative regulation of lipophagy

Keywords

Enzyme and pathway databases

Chemistry

Names & Taxonomy

Protein names

  • Recommended name
    Sphingolipid delta(4)-desaturase DES1
  • EC number
  • Alternative names
    • Degenerative spermatocyte homolog 1
      (DES-1
      )
    • Dihydroceramide desaturase-1

Gene names

    • Name
      ifc
    • ORF names
      CG9078

Organism names

  • Taxonomic identifier
  • Strain
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    Q94515

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane41-61Helical
Transmembrane68-88Helical
Transmembrane107-127Helical
Transmembrane157-177Helical
Transmembrane187-206Helical
Transmembrane208-230Helical

Keywords

Phenotypes & Variants

Disruption phenotype

Primary spermatocytes become mature in size but degenerate without initiating meiotic chromosome condensation in their nuclei. The mutation does not affect female fertility but leads to semi-lethality both in males and females during embryonic stages (PubMed:9003299).
Homozigous mutant spermatids show a misshapen Nebenkern, which varies in size and is associated with multiple nuclei (PubMed:9819060).

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004536211-321Sphingolipid delta4-desaturase DES1

Proteomic databases

Expression

Tissue specificity

Testes.

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    321
  • Mass (Da)
    37,213
  • Last updated
    1997-02-01 v1
  • MD5 Checksum
    D1B931025699BB5B2EF17D12C141887D
MGQKVSRTDFEWVYTEEPHASRRKIILEKYPQIKKLFGHDPNFKWVAGAMVLTQILALFVVKDLSWSWLIVAAYCFGGIINHSLMLAVHEISHNLAFGHSRPMHNRILGFICNLPIGLPMSISFKKYHLEHHRYQGDEAIDTDIPTLLEARLFDTTFGKFLWVCLQPFFYIFRPLIINPKPPTRLEIINTVVQLTFNALIVYFLGWKPLAYLLIGSILAMGLHPVAGHFISEHYMFAKGFETYSYYGPLNWITFNVGYHNEHHDFPAVPGSRLPEVKRIAKEFYDTMPQHTSWTRVLYDFIMDPAVGPYARVKRRQRGLAS

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
M9PC47M9PC47_DROMEifc102

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE014134
EMBL· GenBank· DDBJ
AAF52318.1
EMBL· GenBank· DDBJ
Genomic DNA
X94180
EMBL· GenBank· DDBJ
CAA63889.1
EMBL· GenBank· DDBJ
Genomic DNA
AY061196
EMBL· GenBank· DDBJ
AAL28744.1
EMBL· GenBank· DDBJ
mRNA
AF466379
EMBL· GenBank· DDBJ
AAM12535.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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