Q93ZJ9 · MLN51_ARATH
- ProteinProtein MLN51 homolog
- GeneMLN51
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids605 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA-helicase activities of EIF4A3.
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | exon-exon junction complex | |
Molecular Function | mRNA binding | |
Biological Process | mRNA processing | |
Biological Process | mRNA transport | |
Biological Process | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | |
Biological Process | regulation of translation | |
Biological Process | RNA splicing |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameProtein MLN51 homolog
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ93ZJ9
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000440128 | 1-605 | Protein MLN51 homolog | |||
Sequence: MAPDGVEDSDYESDPDELNRSLATRRREASDDDEDDEEADDHDKLRAAIQIHSDEHSGVVVVDSDDNEGLHIEDSYGDDDDEEEDGDYGQVDDHVEYIADNNDKTIVAGNGTDDSAATDLVDGEEQKKKEPFAVPTAGAFYMHDDRFQELDAASNRRMRGGRRLWQSRDERKWGHDKFEEMNTQKQQYDRRTSRGRGRGRGQGRGQDRGQSRGNNSKEFTGNGHQNQFPKAVTRGRGARRYEVALRNGNQAPSVQTKQSQNSSVEVSHVDLGRPPTETATLETEAIQAKKNVFASSLNSASPPFYPSRSNNNLAQKDVQAGMGRLHINENPNPTGKKFGNTKSSSLWGRTAQTTSHGRGVPPHGQVLYQQSPNQGDKVSSPMQIRGMPKGTDQSCTQLPGQVFNQHSAVISLLPSSPPKTGSSENPYLSGEIESAVETGALVAKGKGSLQPSGRGSFMYGGTQFMGPAGMAAGHGNPNFPAFLPVMQFGGQHGGVPTFGMALPGYFQPEHGTGNPEMTWLPILAGPGALGGSYCPPYTVLDGSYQADKPGLPSSAGSSSQENSSNNPNDEEPMERPEVTNNGNSQRSNSNPNKQPRRYSEMSFSK | ||||||
Modified residue | 30 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-88 | Disordered | ||||
Sequence: MAPDGVEDSDYESDPDELNRSLATRRREASDDDEDDEEADDHDKLRAAIQIHSDEHSGVVVVDSDDNEGLHIEDSYGDDDDEEEDGDY | ||||||
Compositional bias | 15-30 | Basic and acidic residues | ||||
Sequence: PDELNRSLATRRREAS | ||||||
Compositional bias | 72-88 | Acidic residues | ||||
Sequence: IEDSYGDDDDEEEDGDY | ||||||
Region | 101-132 | Disordered | ||||
Sequence: NNDKTIVAGNGTDDSAATDLVDGEEQKKKEPF | ||||||
Compositional bias | 151-205 | Basic and acidic residues | ||||
Sequence: DAASNRRMRGGRRLWQSRDERKWGHDKFEEMNTQKQQYDRRTSRGRGRGRGQGRG | ||||||
Region | 151-275 | Disordered | ||||
Sequence: DAASNRRMRGGRRLWQSRDERKWGHDKFEEMNTQKQQYDRRTSRGRGRGRGQGRGQDRGQSRGNNSKEFTGNGHQNQFPKAVTRGRGARRYEVALRNGNQAPSVQTKQSQNSSVEVSHVDLGRPP | ||||||
Compositional bias | 207-229 | Polar residues | ||||
Sequence: DRGQSRGNNSKEFTGNGHQNQFP | ||||||
Compositional bias | 248-267 | Polar residues | ||||
Sequence: GNQAPSVQTKQSQNSSVEVS | ||||||
Region | 350-380 | Disordered | ||||
Sequence: TAQTTSHGRGVPPHGQVLYQQSPNQGDKVSS | ||||||
Compositional bias | 366-380 | Polar residues | ||||
Sequence: VLYQQSPNQGDKVSS | ||||||
Region | 544-605 | Disordered | ||||
Sequence: YQADKPGLPSSAGSSSQENSSNNPNDEEPMERPEVTNNGNSQRSNSNPNKQPRRYSEMSFSK | ||||||
Compositional bias | 550-567 | Polar residues | ||||
Sequence: GLPSSAGSSSQENSSNNP | ||||||
Compositional bias | 577-605 | Polar residues | ||||
Sequence: EVTNNGNSQRSNSNPNKQPRRYSEMSFSK |
Sequence similarities
Belongs to the CASC3 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length605
- Mass (Da)65,693
- Last updated2001-12-01 v1
- Checksum7FF61B6C323EE41F
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A1P8AV18 | A0A1P8AV18_ARATH | BTZ1 | 599 |
Sequence caution
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 15-30 | Basic and acidic residues | ||||
Sequence: PDELNRSLATRRREAS | ||||||
Compositional bias | 72-88 | Acidic residues | ||||
Sequence: IEDSYGDDDDEEEDGDY | ||||||
Compositional bias | 151-205 | Basic and acidic residues | ||||
Sequence: DAASNRRMRGGRRLWQSRDERKWGHDKFEEMNTQKQQYDRRTSRGRGRGRGQGRG | ||||||
Compositional bias | 207-229 | Polar residues | ||||
Sequence: DRGQSRGNNSKEFTGNGHQNQFP | ||||||
Compositional bias | 248-267 | Polar residues | ||||
Sequence: GNQAPSVQTKQSQNSSVEVS | ||||||
Compositional bias | 366-380 | Polar residues | ||||
Sequence: VLYQQSPNQGDKVSS | ||||||
Compositional bias | 550-567 | Polar residues | ||||
Sequence: GLPSSAGSSSQENSSNNP | ||||||
Compositional bias | 577-605 | Polar residues | ||||
Sequence: EVTNNGNSQRSNSNPNKQPRRYSEMSFSK |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC009322 EMBL· GenBank· DDBJ | AAD55481.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
AC011717 EMBL· GenBank· DDBJ | AAG52246.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
CP002684 EMBL· GenBank· DDBJ | AEE36342.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002684 EMBL· GenBank· DDBJ | AEE36343.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002684 EMBL· GenBank· DDBJ | ANM60522.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY057486 EMBL· GenBank· DDBJ | AAL09720.1 EMBL· GenBank· DDBJ | mRNA | ||
BT004550 EMBL· GenBank· DDBJ | AAO42796.1 EMBL· GenBank· DDBJ | mRNA | ||
AK317141 EMBL· GenBank· DDBJ | BAH19827.1 EMBL· GenBank· DDBJ | mRNA |