Q93ZJ9 · MLN51_ARATH

Function

function

Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA-helicase activities of EIF4A3.

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentexon-exon junction complex
Molecular FunctionmRNA binding
Biological ProcessmRNA processing
Biological ProcessmRNA transport
Biological Processnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
Biological Processregulation of translation
Biological ProcessRNA splicing

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Protein MLN51 homolog
  • Alternative names
    • Protein CASC3 homolog
    • Protein barentsz
      (Btz
      )

Gene names

    • Name
      MLN51
    • Synonyms
      CASC3
    • ORF names
      F18B13.8
      , F19K16.3
    • Ordered locus names
      At1g80000

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q93ZJ9
  • Secondary accessions
    • Q9S770

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Nucleus
Cytoplasm
Note: Nucleocytoplasmic shuttling protein. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA.

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00004401281-605Protein MLN51 homolog
Modified residue30Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Weakly interacts with EIF4A3.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region1-88Disordered
Compositional bias15-30Basic and acidic residues
Compositional bias72-88Acidic residues
Region101-132Disordered
Compositional bias151-205Basic and acidic residues
Region151-275Disordered
Compositional bias207-229Polar residues
Compositional bias248-267Polar residues
Region350-380Disordered
Compositional bias366-380Polar residues
Region544-605Disordered
Compositional bias550-567Polar residues
Compositional bias577-605Polar residues

Sequence similarities

Belongs to the CASC3 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    605
  • Mass (Da)
    65,693
  • Last updated
    2001-12-01 v1
  • Checksum
    7FF61B6C323EE41F
MAPDGVEDSDYESDPDELNRSLATRRREASDDDEDDEEADDHDKLRAAIQIHSDEHSGVVVVDSDDNEGLHIEDSYGDDDDEEEDGDYGQVDDHVEYIADNNDKTIVAGNGTDDSAATDLVDGEEQKKKEPFAVPTAGAFYMHDDRFQELDAASNRRMRGGRRLWQSRDERKWGHDKFEEMNTQKQQYDRRTSRGRGRGRGQGRGQDRGQSRGNNSKEFTGNGHQNQFPKAVTRGRGARRYEVALRNGNQAPSVQTKQSQNSSVEVSHVDLGRPPTETATLETEAIQAKKNVFASSLNSASPPFYPSRSNNNLAQKDVQAGMGRLHINENPNPTGKKFGNTKSSSLWGRTAQTTSHGRGVPPHGQVLYQQSPNQGDKVSSPMQIRGMPKGTDQSCTQLPGQVFNQHSAVISLLPSSPPKTGSSENPYLSGEIESAVETGALVAKGKGSLQPSGRGSFMYGGTQFMGPAGMAAGHGNPNFPAFLPVMQFGGQHGGVPTFGMALPGYFQPEHGTGNPEMTWLPILAGPGALGGSYCPPYTVLDGSYQADKPGLPSSAGSSSQENSSNNPNDEEPMERPEVTNNGNSQRSNSNPNKQPRRYSEMSFSK

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1P8AV18A0A1P8AV18_ARATHBTZ1599

Sequence caution

The sequence AAD55481.1 differs from that shown. Reason: Erroneous gene model prediction
The sequence AAG52246.1 differs from that shown. Reason: Erroneous gene model prediction

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias15-30Basic and acidic residues
Compositional bias72-88Acidic residues
Compositional bias151-205Basic and acidic residues
Compositional bias207-229Polar residues
Compositional bias248-267Polar residues
Compositional bias366-380Polar residues
Compositional bias550-567Polar residues
Compositional bias577-605Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC009322
EMBL· GenBank· DDBJ
AAD55481.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
AC011717
EMBL· GenBank· DDBJ
AAG52246.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
CP002684
EMBL· GenBank· DDBJ
AEE36342.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002684
EMBL· GenBank· DDBJ
AEE36343.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002684
EMBL· GenBank· DDBJ
ANM60522.1
EMBL· GenBank· DDBJ
Genomic DNA
AY057486
EMBL· GenBank· DDBJ
AAL09720.1
EMBL· GenBank· DDBJ
mRNA
BT004550
EMBL· GenBank· DDBJ
AAO42796.1
EMBL· GenBank· DDBJ
mRNA
AK317141
EMBL· GenBank· DDBJ
BAH19827.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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