Q93WK5 · APRR7_ARATH

Function

function

Transcriptional repressor of CCA1 and LHY, and positive regulator of LWD1 and LWD2 expression. Represses the expression of other clock proteins and master regulators of plant growth, development and response to abiotic stress. Involved in the positive and negative feedback loops of the circadian clock. Controls photoperiodic flowering response and temperature compensation. Expression of several members of the ARR-like family is controlled by circadian rhythm. APRR9, APRR7, and APRR5 coordinately act on the upstream region of the target genes to repress their expression from noon until midnight. The particular coordinated sequential expression of APRR9, APRR7, APRR5, APRR3 and APPR1 result to circadian waves that may be at the basis of the endogenous circadian clock.

Miscellaneous

Regulated at the level of mRNA maturation and alternative splicing by SKIP (PubMed:22942380).
The expression of APRR9, APRR7, and APRR5 requires the presence of LWD1 and/or LWD2, indicating the existence of a positive feedback loop within the circadian clock (PubMed:21357491).

Caution

Lacks the phospho-accepting Asp (here Glu-130), present in the receiver domain, which is one of the conserved features of two-component response regulators (ARRs) family.

GO annotations

AspectTerm
Cellular Componentmitochondrion
Cellular Componentnucleus
Molecular FunctionDNA binding
Biological Processcircadian rhythm
Biological Processcytokinin-activated signaling pathway
Biological Processnegative regulation of DNA-templated transcription
Biological Processphosphorelay signal transduction system
Biological Processred or far-red light signaling pathway
Biological Processregulation of DNA-templated transcription

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Two-component response regulator-like APRR7
  • Alternative names
    • Pseudo-response regulator 7

Gene names

    • Name
      APRR7
    • ORF names
      F9G14_120
    • Ordered locus names
      At5g02810

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q93WK5
  • Secondary accessions
    • Q9LZ04

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Nucleus

Keywords

Phenotypes & Variants

Disruption phenotype

Insensitive to the effect of sucrose on the circadian period.

Variants

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The viewer provides 52 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000814391-727Two-component response regulator-like APRR7

Post-translational modification

Phosphorylated. Phosphorylation varies throughout the diurnal cycle.

Keywords

Proteomic databases

PTM databases

Expression

Induction

Up-regulated by heat-shock and light at dawn, and down-regulated by the sugars produced by photosynthesis.

Gene expression databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q93WK5PYL8 Q9FGM13EBI-25528701, EBI-2429535

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region1-47Disordered
Compositional bias10-43Basic and acidic residues
Domain79-197Response regulatory
Compositional bias203-218Polar residues
Region203-265Disordered
Compositional bias234-264Polar residues
Region291-312Disordered
Region339-416Disordered
Region464-487Disordered
Region509-560Disordered
Compositional bias606-664Polar residues
Region606-670Disordered
Domain669-711CCT

Sequence similarities

Belongs to the ARR-like family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    727
  • Mass (Da)
    79,663
  • Last updated
    2001-12-01 v1
  • Checksum
    13057E6AE6E50C00
MNANEEGEGSRYPITDRKTGETKFDRVESRTEKHSEEEKTNGITMDVRNGSSGGLQIPLSQQTAATVCWERFLHVRTIRVLLVENDDCTRYIVTALLRNCSYEVVEASNGIQAWKVLEDLNNHIDIVLTEVIMPYLSGIGLLCKILNHKSRRNIPVIMMSSHDSMGLVFKCLSKGAVDFLVKPIRKNELKILWQHVWRRCQSSSGSGSESGTHQTQKSVKSKSIKKSDQDSGSSDENENGSIGLNASDGSSDGSGAQSSWTKKAVDVDDSPRAVSLWDRVDSTCAQVVHSNPEFPSNQLVAPPAEKETQEHDDKFEDVTMGRDLEISIRRNCDLALEPKDEPLSKTTGIMRQDNSFEKSSSKWKMKVGKGPLDLSSESPSSKQMHEDGGSSFKAMSSHLQDNREPEAPNTHLKTLDTNEASVKISEELMHVEHSSKRHRGTKDDGTLVRDDRNVLRRSEGSAFSRYNPASNANKISGGNLGSTSLQDNNSQDLIKKTEAAYDCHSNMNESLPHNHRSHVGSNNFDMSSTTENNAFTKPGAPKVSSAGSSSVKHSSFQPLPCDHHNNHASYNLVHVAERKKLPPQCGSSNVYNETIEGNNNTVNYSVNGSVSGSGHGSNGPYGSSNGMNAGGMNMGSDNGAGKNGNGDGSGSGSGSGSGNLADENKISQREAALTKFRQKRKERCFRKKVRYQSRKKLAEQRPRVRGQFVRKTAAATDDNDIKNIEDS

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1P8BCB0A0A1P8BCB0_ARATHPRR7583

Sequence caution

The sequence CAB86035.1 differs from that shown. Reason: Erroneous gene model prediction

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias10-43Basic and acidic residues
Compositional bias203-218Polar residues
Compositional bias234-264Polar residues
Compositional bias606-664Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB046954
EMBL· GenBank· DDBJ
BAB13742.1
EMBL· GenBank· DDBJ
mRNA
AL162973
EMBL· GenBank· DDBJ
CAB86035.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
CP002688
EMBL· GenBank· DDBJ
AED90520.1
EMBL· GenBank· DDBJ
Genomic DNA
AY039943
EMBL· GenBank· DDBJ
AAK64047.1
EMBL· GenBank· DDBJ
mRNA
AY142560
EMBL· GenBank· DDBJ
AAN13129.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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