Q93W57 · HSDA_SESIN

Function

function

Has dehydrogenase activity against corticosterone (11 beta-hydroxysteroid) and estradiol (17 beta-hydroxysteroid), with higher activity against estradiol. Possesses higher dehydrogenase activity with NADP+ than NAD+ regardless of the sterol substrate. May be involved in signal transduction regulated by various sterols.

Catalytic activity

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site54-80NADP+ (UniProtKB | ChEBI)
Binding site105NADP+ (UniProtKB | ChEBI)
Binding site132-135NADP+ (UniProtKB | ChEBI)
Binding site184substrate
Active site197Proton acceptor
Binding site197-201NADP+ (UniProtKB | ChEBI)
Binding site201NADP+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentlipid droplet
Cellular Componentmembrane
Molecular Function11-beta-hydroxysteroid dehydrogenase (NAD+) activity
Molecular Function11-beta-hydroxysteroid dehydrogenase (NADP+) activity
Molecular Function17-beta-hydroxysteroid dehydrogenase (NADP+) activity
Molecular Functionestradiol 17-beta-dehydrogenase [NAD(P)+] activity
Biological Processsteroid metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    11-beta-hydroxysteroid dehydrogenase A
  • EC number
  • Alternative names
    • 17-beta-hydroxysteroid dehydrogenase A
      (EC:1.1.1.62
      ) . EC:1.1.1.62 (UniProtKB | ENZYME | Rhea)
    • Seed oil body protein 2
    • Steroleosin-A

Gene names

    • Name
      SOP2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > asterids > lamiids > Lamiales > Pedaliaceae > Sesamum

Accessions

  • Primary accession
    Q93W57

Proteomes

Genome annotation databases

Subcellular Location

Lipid droplet
Membrane
; Single-pass type II membrane protein
Note: Surface of oil bodies. Exists at a monolayer lipid/water interface.

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane10-30Helical; Signal-anchor for type II membrane protein

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004499581-34811-beta-hydroxysteroid dehydrogenase A

Expression

Tissue specificity

Expressed in seeds (at protein level) (PubMed:11950969, PubMed:9816677).
Not expressed in stem, leaf or root (at protein level) (PubMed:9816677).

Developmental stage

Expressed during seed maturation (PubMed:11950969, PubMed:15331088, PubMed:9816677).
Appears in maturing seeds approximately 3 weeks after flowering and thereafter the level is continuously increased till the late stage of seed maturation (at protein level) (PubMed:15331088).
Detected in maturing seeds approximately 2 weeks after flowering and expression is maintained at a substantial level thereafter until the late stage of seed maturation (PubMed:11950969).

Structure

Family & Domains

Features

Showing features for motif.

TypeIDPosition(s)Description
Motif13-26Proline-knob

Domain

The proline-knob motif may be involved in the targeting to oil bodies.

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    348
  • Mass (Da)
    39,568
  • Last updated
    2001-12-01 v1
  • Checksum
    53A0C6DF804CB59B
MDLIHTFLNLIAPPFTFFFLLFFLPPFQIFKFFLSILGTLFSEDVAGKVVVITGASSGIGESLAYEYAKRGACLVLAARRERSLQEVAERARDLGSPDVVVVRADVSKAEDCRKVVDQTMNRFGRLDHLVNNAGIMSVSMLEEVEDITGYRETMDINFWGYVYMTRFAAPYLRNSRGRIVVLSSSSSWMPTPRMSFYNASKAAISQFFETLRVEFGPDIGITLVTPGFIESELTQGKFYNAGERVIDQDMRDVQVSTTPILRVESAARSIVRSAIRGERYVTEPAWFRVTYWWKLFCPEVMEWVFRLMYLASPGEPEKETFGKKVLDYTGVKSLLYPETVQVPEPKND

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF302806
EMBL· GenBank· DDBJ
AAL09328.1
EMBL· GenBank· DDBJ
mRNA
AF421889
EMBL· GenBank· DDBJ
AAL13315.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp