Q93VQ0 · VCL1_ARATH

Function

function

Required for vacuole biogenesis and vacuole enlargment in dividing and expanding cells. Involved in the docking or fusion of prevacuolar vesicles. Important for the function of both male and female gametophytes, but is not essential for the germination and development of pollen.

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentCORVET complex
Cellular Componentendoplasmic reticulum
Cellular ComponentHOPS complex
Cellular Componentplant-type vacuole membrane
Cellular Componentprotein-containing complex
Biological Processintracellular protein transport
Biological Processnegative regulation of embryonic development
Biological Processvacuole organization
Biological Processvesicle fusion with vacuole

Names & Taxonomy

Protein names

  • Recommended name
    Protein VACUOLELESS1
  • Alternative names
    • Vacuolar protein sorting-associated protein 16 homolog

Gene names

    • Name
      VCL1
    • ORF names
      T8P21.7
    • Ordered locus names
      At2g38020

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q93VQ0
  • Secondary accessions
    • B9DFU5
    • F4IRY5

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

Absence of vacuoles in the embryo and accumulation of small vesicles and autophagosomes. Embryo lethality at late torpedo stage.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 46 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004259701-858Protein VACUOLELESS1

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in roots, leaves, stems, siliques, flowers and mature pollen.

Developmental stage

Expressed throughout development.

Gene expression databases

Interaction

Subunit

Core component of at least two putative endosomal tethering complexes, the homotypic fusion and vacuole protein sorting (HOPS) complex and the class C core vacuole/endosome tethering (CORVET) complex. Their common core is composed of the class C Vps proteins VPS11, VCL1, VPS18 and VPS33, which in HOPS further associates with VPS39 and VPS41 and in CORVET with VPS3.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the VPS16 family.

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q93VQ0-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    858
  • Mass (Da)
    96,632
  • Last updated
    2001-12-01 v1
  • Checksum
    94D8658581CA7023
MANVSVAAEWQLLYDRYYRKPEIYQMKWKHVDLSRNKVACASFGGPIAVIRDDSKIVQLYAESALRKLRIFNSAGILLSETVWKHPGGRLIGMSWSDDQTLICIVQDGTIYRYNIHAELIEPNMSMGQECFEQNVVECVFWGNGVVCLTEGGQLICIFDFKTMKPSKLPDVPGLAEDDLLQPICLTVREPKYTMSGIAEVLVAVGDDIFVVEEDMVQTIRFDEPSVDDSEMQNDDSGNLIGVVQKMIVSPNGKFLTLFTHDGRIVVVDMETKQIAIDYSCESALPPQQMAWCGMDSVLLYWDEDLMMVGPVGDPVHYFYDEPIILIPECDGVRILSNTNLEFLQRVPDSTESIFKIGSTSPAALLYDALDHFDRRSAKADENLRLIRSSLSEAVESCIDAAGHEFDVTRQRALLRAASYGQAFCSNFQRERVQETCRTLRVLNAVRDPAIGIPLSIQQYKLLTPVVLISRLINANCHLLALRISEYLDMNKEVVIMHWACAKITASPSTPDSHLLEILLDKLQLCKGISYAAVATHADNCGRRKLAAMLVEHEPRSTKQVPLLLSIGEEDTALVKATESGDTDLVYLVIFHIWQKRPPLEFFAMIQGRVLARDLFVAYARCHKHEFLKDFFLSTGQIHEVAFLLWKESWDMGKNPMASKGSPLHGPRIKLIEKARNLFSQTKEHTFESKAAEEHAKLLKIQHELEASTKQAIFVDSSINDTIRTCIVLGNNRAAIKVKTEFKVSDKRWYWLKAFALATIKDWAALEKFSKEKRPPMGFRPFVEACIDADEKAEALKYIPKLSDLVERGEAYARIGMAKEAADCAAQANDGGELLERFRKTFVQNAIFDTLLMPFQGAS

Q93VQ0-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 810-834: AYARIGMAKEAADCAAQANDGGELL → VCPAYKTCTWIIGLDMYKIYRNLLV
    • 835-858: Missing

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_053914810-834in isoform 2
Alternative sequenceVSP_053915835-858in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF359240
EMBL· GenBank· DDBJ
AAK43713.1
EMBL· GenBank· DDBJ
mRNA
CP002685
EMBL· GenBank· DDBJ
AEC09479.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002685
EMBL· GenBank· DDBJ
AEC09480.1
EMBL· GenBank· DDBJ
Genomic DNA
AY048248
EMBL· GenBank· DDBJ
AAK82510.1
EMBL· GenBank· DDBJ
mRNA
AY139799
EMBL· GenBank· DDBJ
AAM98105.1
EMBL· GenBank· DDBJ
mRNA
AK316906
EMBL· GenBank· DDBJ
BAH19612.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp