STMN2 mediates nuclear translocation of Smad2/3 and enhances TGFbeta signaling by destabilizing microtubules to promote epithelial-mesenchymal transition in hepatocellular carcinoma.
STMN2 is a key regulator functionally connected to known Parkinson's disease risk genes. Network analysis predicts a function of human STMN2 in synaptic trafficking. [Meta-Analysis}
premature polyadenylation-mediated reduction in stathmin-2 is a hallmark of ALS-FTD that functionally links reduced nuclear TDP-43 function to enhanced neuronal vulnerability.
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