Q92PB7 · Q92PB7_RHIME

Function

function

Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Organic acid metabolism; glycolate biosynthesis; glycolate from 2-phosphoglycolate: step 1/1.

Features

Showing features for active site, binding site.

Type
IDPosition(s)Description
Active site9Nucleophile
Binding site9Mg2+ (UniProtKB | ChEBI)
Binding site11Mg2+ (UniProtKB | ChEBI)
Binding site171Mg2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionmetal ion binding
Molecular Functionphosphoglycolate phosphatase activity
Biological Processcarbohydrate metabolic process
Biological Processdephosphorylation
Biological ProcessDNA repair
Biological Processglycolate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoglycolate phosphatase
  • EC number
  • Short names
    PGP
    ; PGPase

Gene names

    • Name
      gph1
    • Synonyms
      gph
    • ORF names
      SMc00151

Organism names

Accessions

  • Primary accession
    Q92PB7

Proteomes

Subcellular Location

Family & Domains

Sequence similarities

Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    227
  • Mass (Da)
    24,483
  • Last updated
    2001-12-01 v1
  • MD5 Checksum
    6DACBE2FF3C799B8F6E1AFF69950E122
MSLPLVVFDLDGTLVDTAPDLVASLNHAVTQAGIEPVTYADLTHLVGHGARAMIERTFALRGRTIAEEELTWQMKEFVDFYHGSMPGESLPYPGLIEALDRLQDAGLKLAVCTNKPEMLAKRLLEGLGLLGRFAAISGGDTFTVRKPHADHLLSTVSNAGGMAERAVMVGDSLNDVLVARNASVPSIVVPFGYSDVPIESLLPDRIIGHFDELTPDLVETVLSRKPK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL591688
EMBL· GenBank· DDBJ
CAC46436.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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