Q92901 · RL3L_HUMAN
- ProteinRibosomal protein uL3-like
- GeneRPL3L
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids407 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Heart- and skeletal muscle-specific component of the ribosome, which regulates muscle function. Component of the large ribosomal subunit in striated muscle cells: replaces the RPL3 paralog in the ribosome in these cells. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Inhibits myotube growth and muscle function.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytosolic large ribosomal subunit | |
Cellular Component | membrane | |
Cellular Component | ribosome | |
Molecular Function | RNA binding | |
Molecular Function | structural constituent of ribosome | |
Biological Process | negative regulation of myotube differentiation | |
Biological Process | regulation of striated muscle tissue development | |
Biological Process | translation |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRibosomal protein uL3-like
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ92901
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Disease & Variants
Involvement in disease
Cardiomyopathy, dilated, 2D (CMD2D)
- Note
- DescriptionA form of dilated cardiomyopathy, a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. CMD2D is an autosomal recessive, severe form with neonatal onset.
- See alsoMIM:619371
Natural variants in CMD2D
Variant ID | Position(s) | Change | Description | |
---|---|---|---|---|
VAR_085880 | 27 | G>D | in CMD2D; uncertain significance; dbSNP:rs770344400 | |
VAR_087799 | 51 | A>T | in CMD2D; uncertain significance | |
VAR_085881 | 116 | R>H | in CMD2D; uncertain significance; dbSNP:rs376654625 | |
VAR_085882 | 161 | R>W | in CMD2D; uncertain significance; dbSNP:rs143544112 | |
VAR_085883 | 189 | T>M | in CMD2D; uncertain significance; dbSNP:rs924125081 | |
VAR_087800 | 231 | V>F | in CMD2D; uncertain significance | |
VAR_085884 | 308 | D>N | in CMD2D; uncertain significance; dbSNP:rs771732216 | |
VAR_085885 | 308 | D>V | in CMD2D; uncertain significance | |
VAR_085886 | 343 | R>W | in CMD2D; uncertain significance; dbSNP:rs1465045317 |
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_085880 | 27 | in CMD2D; uncertain significance; dbSNP:rs770344400 | |||
Sequence: G → D | ||||||
Natural variant | VAR_087799 | 51 | in CMD2D; uncertain significance | |||
Sequence: A → T | ||||||
Natural variant | VAR_085881 | 116 | in CMD2D; uncertain significance; dbSNP:rs376654625 | |||
Sequence: R → H | ||||||
Natural variant | VAR_085882 | 161 | in CMD2D; uncertain significance; dbSNP:rs143544112 | |||
Sequence: R → W | ||||||
Natural variant | VAR_085883 | 189 | in CMD2D; uncertain significance; dbSNP:rs924125081 | |||
Sequence: T → M | ||||||
Natural variant | VAR_087800 | 231 | in CMD2D; uncertain significance | |||
Sequence: V → F | ||||||
Natural variant | VAR_034461 | 291 | in dbSNP:rs34265469 | |||
Sequence: P → L | ||||||
Natural variant | VAR_085884 | 308 | in CMD2D; uncertain significance; dbSNP:rs771732216 | |||
Sequence: D → N | ||||||
Natural variant | VAR_085885 | 308 | in CMD2D; uncertain significance | |||
Sequence: D → V | ||||||
Natural variant | VAR_085886 | 343 | in CMD2D; uncertain significance; dbSNP:rs1465045317 | |||
Sequence: R → W |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 609 variants from UniProt as well as other sources including ClinVar and dbSNP.
Keywords
- Disease
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000077233 | 1-407 | UniProt | Ribosomal protein uL3-like | |||
Sequence: MSHRKFSAPRHGHLGFLPHKRSHRHRGKVKTWPRDDPSQPVHLTAFLGYKAGMTHTLREVHRPGLKISKREEVEAVTIVETPPLVVVGVVGYVATPRGLRSFKTIFAEHLSDECRRRFYKDWHKSKKKAFTKACKRWRDTDGKKQLQKDFAAMKKYCKVIRVIVHTQMKLLPFRQKKAHIMEIQLNGGTVAEKVAWAQARLEKQVPVHSVFSQSEVIDVIAVTKGRGVKGVTSRWHTKKLPRKTHKGLRKVACIGAWHPARVGCSIARAGQKGYHHRTELNKKIFRIGRGPHMEDGKLVKNNASTSYDVTAKSITPLGGFPHYGEVNNDFVMLKGCIAGTKKRVITLRKSLLVHHSRQAVENIELKFIDTTSKFGHGRFQTAQEKRAFMGPQKKHLEKETPETSGDL | |||||||
Modified residue (large scale data) | 372 | PRIDE | Phosphoserine | ||||
Sequence: S |
Proteomic databases
PTM databases
Expression
Interaction
Subunit
Component of the large ribosomal subunit in striated muscle cells.
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-28 | Basic residues | ||||
Sequence: MSHRKFSAPRHGHLGFLPHKRSHRHRGK | ||||||
Region | 1-35 | Disordered | ||||
Sequence: MSHRKFSAPRHGHLGFLPHKRSHRHRGKVKTWPRD | ||||||
Region | 387-407 | Disordered | ||||
Sequence: AFMGPQKKHLEKETPETSGDL | ||||||
Compositional bias | 388-407 | Basic and acidic residues | ||||
Sequence: FMGPQKKHLEKETPETSGDL |
Sequence similarities
Belongs to the universal ribosomal protein uL3 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length407
- Mass (Da)46,296
- Last updated2007-01-23 v3
- Checksum1965327E225F80D2
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
H3BQN3 | H3BQN3_HUMAN | RPL3L | 43 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-28 | Basic residues | ||||
Sequence: MSHRKFSAPRHGHLGFLPHKRSHRHRGK | ||||||
Compositional bias | 388-407 | Basic and acidic residues | ||||
Sequence: FMGPQKKHLEKETPETSGDL |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U65581 EMBL· GenBank· DDBJ | AAC50777.1 EMBL· GenBank· DDBJ | mRNA | ||
AE006640 EMBL· GenBank· DDBJ | AAK61301.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC050413 EMBL· GenBank· DDBJ | AAH50413.1 EMBL· GenBank· DDBJ | mRNA |