Q92847 · GHSR_HUMAN
- ProteinGrowth hormone secretagogue receptor type 1
- GeneGHSR
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids366 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Molecular function
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameGrowth hormone secretagogue receptor type 1
- Short namesGHS-R
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ92847
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-40 | Extracellular | ||||
Sequence: MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPA | ||||||
Transmembrane | 41-66 | Helical; Name=1 | ||||
Sequence: PLLAGVTATCVALFVVGIAGNLLTML | ||||||
Topological domain | 67-72 | Cytoplasmic | ||||
Sequence: VVSRFR | ||||||
Transmembrane | 73-96 | Helical; Name=2 | ||||
Sequence: ELRTTTNLYLSSMAFSDLLIFLCM | ||||||
Topological domain | 97-117 | Extracellular | ||||
Sequence: PLDLVRLWQYRPWNFGDLLCK | ||||||
Transmembrane | 118-139 | Helical; Name=3 | ||||
Sequence: LFQFVSESCTYATVLTITALSV | ||||||
Topological domain | 140-162 | Cytoplasmic | ||||
Sequence: ERYFAICFPLRAKVVVTKGRVKL | ||||||
Transmembrane | 163-183 | Helical; Name=4 | ||||
Sequence: VIFVIWAVAFCSAGPIFVLVG | ||||||
Topological domain | 184-211 | Extracellular | ||||
Sequence: VEHENGTDPWDTNECRPTEFAVRSGLLT | ||||||
Transmembrane | 212-235 | Helical; Name=5 | ||||
Sequence: VMVWVSSIFFFLPVFCLTVLYSLI | ||||||
Topological domain | 236-263 | Cytoplasmic | ||||
Sequence: GRKLWRRRRGDAVVGASLRDQNHKQTVK | ||||||
Transmembrane | 264-285 | Helical; Name=6 | ||||
Sequence: MLAVVVFAFILCWLPFHVGRYL | ||||||
Topological domain | 286-302 | Extracellular | ||||
Sequence: FSKSFEPGSLEIAQISQ | ||||||
Transmembrane | 303-326 | Helical; Name=7 | ||||
Sequence: YCNLVSFVLFYLSAAINPILYNIM | ||||||
Topological domain | 327-366 | Cytoplasmic | ||||
Sequence: SKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT |
Keywords
- Cellular component
Disease & Variants
Involvement in disease
Growth hormone deficiency, isolated partial (GHDP)
- Note
- DescriptionA disorder characterized by partial growth hormone deficiency resulting in growth delay and short stature, sometimes associated with recurrent episodes of abdominal pain, vomiting, ketosis and hypoglycemia.
- See alsoMIM:615925
Natural variants in GHDP
Variant ID | Position(s) | Change | Description | |
---|---|---|---|---|
VAR_032705 | 204 | A>E | in GHDP; affects cell-surface expression; impairs constitutive activity; does not affect the ability to respond to ghrelin; dbSNP:rs121917883 | |
VAR_073173 | 237 | R>W | in GHDP; results in partial loss of constitutive activity of the receptor; does not affect response to ghrelin; does not affect receptor cell-surface expression; dbSNP:rs199588904 |
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_049389 | 5 | in dbSNP:rs2232165 | |||
Sequence: T → I | ||||||
Natural variant | VAR_032705 | 204 | in GHDP; affects cell-surface expression; impairs constitutive activity; does not affect the ability to respond to ghrelin; dbSNP:rs121917883 | |||
Sequence: A → E | ||||||
Natural variant | VAR_073173 | 237 | in GHDP; results in partial loss of constitutive activity of the receptor; does not affect response to ghrelin; does not affect receptor cell-surface expression; dbSNP:rs199588904 | |||
Sequence: R → W |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 511 variants from UniProt as well as other sources including ClinVar and dbSNP.
Keywords
- Disease
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for chain, glycosylation, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000069479 | 1-366 | Growth hormone secretagogue receptor type 1 | |||
Sequence: MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT | ||||||
Glycosylation | 13 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 27 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 116↔198 | |||||
Sequence: CKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNEC |
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q92847-1 | GHSR Q92847-1 | 12 | EBI-21459171, EBI-21459171 | |
BINARY | Q92847-1 | GHSR Q92847-2 | 10 | EBI-21459171, EBI-21459245 | |
BINARY | Q92847-1 | SIGMAR1 Q99720 | 8 | EBI-21459171, EBI-3248663 |
Protein-protein interaction databases
Chemistry
Miscellaneous
Structure
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q92847-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1A
- Length366
- Mass (Da)41,329
- Last updated1997-02-01 v1
- ChecksumD1B62710DA9DC0C6
Q92847-2
- Name1B
Features
Showing features for alternative sequence.
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U60179 EMBL· GenBank· DDBJ | AAC50653.1 EMBL· GenBank· DDBJ | mRNA | ||
U60181 EMBL· GenBank· DDBJ | AAC50654.1 EMBL· GenBank· DDBJ | mRNA | ||
AF369786 EMBL· GenBank· DDBJ | AAK71539.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF369786 EMBL· GenBank· DDBJ | AAK71540.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY429112 EMBL· GenBank· DDBJ | AAR07907.1 EMBL· GenBank· DDBJ | mRNA | ||
AY322544 EMBL· GenBank· DDBJ | AAP84357.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471052 EMBL· GenBank· DDBJ | EAW78468.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC069068 EMBL· GenBank· DDBJ | AAH69068.1 EMBL· GenBank· DDBJ | mRNA | ||
BC069374 EMBL· GenBank· DDBJ | AAH69374.1 EMBL· GenBank· DDBJ | mRNA | ||
BC113547 EMBL· GenBank· DDBJ | AAI13548.1 EMBL· GenBank· DDBJ | mRNA |