Q92847 · GHSR_HUMAN

  • Protein
    Growth hormone secretagogue receptor type 1
  • Gene
    GHSR
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell surface
Cellular Componentglutamatergic synapse
Cellular Componentmembrane raft
Cellular Componentneuron projection
Cellular Componentplasma membrane
Cellular Componentpostsynapse
Cellular ComponentSchaffer collateral - CA1 synapse
Cellular Componentsynaptic membrane
Molecular FunctionG protein-coupled receptor activity
Molecular Functiongrowth hormone secretagogue receptor activity
Molecular Functiongrowth hormone-releasing hormone receptor activity
Molecular Functionidentical protein binding
Molecular Functionpeptide hormone binding
Biological Processactin polymerization or depolymerization
Biological Processadult feeding behavior
Biological Processcellular response to insulin stimulus
Biological Processcellular response to insulin-like growth factor stimulus
Biological Processcellular response to lipopolysaccharide
Biological Processcellular response to thyroid hormone stimulus
Biological Processdecidualization
Biological ProcessG protein-coupled receptor signaling pathway
Biological Processghrelin secretion
Biological Processgrowth hormone secretion
Biological Processhormone-mediated signaling pathway
Biological Processinsulin-like growth factor receptor signaling pathway
Biological Processlearning or memory
Biological Processnegative regulation of appetite
Biological Processnegative regulation of inflammatory response
Biological Processnegative regulation of insulin secretion
Biological Processnegative regulation of interleukin-1 beta production
Biological Processnegative regulation of interleukin-6 production
Biological Processnegative regulation of locomotion involved in locomotory behavior
Biological Processnegative regulation of macrophage apoptotic process
Biological Processnegative regulation of norepinephrine secretion
Biological Processnegative regulation of tumor necrosis factor production
Biological Processpositive regulation of appetite
Biological Processpositive regulation of eating behavior
Biological Processpositive regulation of fatty acid metabolic process
Biological Processpositive regulation of insulin-like growth factor receptor signaling pathway
Biological Processpositive regulation of multicellular organism growth
Biological Processpositive regulation of small intestinal transit
Biological Processpositive regulation of small intestine smooth muscle contraction
Biological Processpositive regulation of sprouting angiogenesis
Biological Processpositive regulation of vascular endothelial cell proliferation
Biological Processpostsynaptic modulation of chemical synaptic transmission
Biological Processregulation of gastric motility
Biological Processregulation of growth hormone secretion
Biological Processregulation of hindgut contraction
Biological Processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
Biological Processregulation of postsynapse organization
Biological Processregulation of synapse assembly
Biological Processregulation of transmission of nerve impulse
Biological Processresponse to dexamethasone
Biological Processresponse to estradiol
Biological Processresponse to follicle-stimulating hormone
Biological Processresponse to food
Biological Processresponse to growth hormone
Biological Processresponse to hormone
Biological Processresponse to L-glutamate
Biological Processspermatogenesis

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Growth hormone secretagogue receptor type 1
  • Short names
    GHS-R
  • Alternative names
    • GH-releasing peptide receptor (GHRP)
    • Ghrelin receptor

Gene names

    • Name
      GHSR

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q92847
  • Secondary accessions
    • Q14D12
    • Q6ISR8
    • Q92848
    • Q96RJ7

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-40Extracellular
Transmembrane41-66Helical; Name=1
Topological domain67-72Cytoplasmic
Transmembrane73-96Helical; Name=2
Topological domain97-117Extracellular
Transmembrane118-139Helical; Name=3
Topological domain140-162Cytoplasmic
Transmembrane163-183Helical; Name=4
Topological domain184-211Extracellular
Transmembrane212-235Helical; Name=5
Topological domain236-263Cytoplasmic
Transmembrane264-285Helical; Name=6
Topological domain286-302Extracellular
Transmembrane303-326Helical; Name=7
Topological domain327-366Cytoplasmic

Keywords

Disease & Variants

Involvement in disease

Growth hormone deficiency, isolated partial (GHDP)

  • Note
    • The disease is caused by variants affecting the gene represented in this entry
  • Description
    A disorder characterized by partial growth hormone deficiency resulting in growth delay and short stature, sometimes associated with recurrent episodes of abdominal pain, vomiting, ketosis and hypoglycemia.
  • See also
    MIM:615925
Natural variants in GHDP
Variant IDPosition(s)ChangeDescription
VAR_032705204A>Ein GHDP; affects cell-surface expression; impairs constitutive activity; does not affect the ability to respond to ghrelin; dbSNP:rs121917883
VAR_073173237R>Win GHDP; results in partial loss of constitutive activity of the receptor; does not affect response to ghrelin; does not affect receptor cell-surface expression; dbSNP:rs199588904

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_0493895in dbSNP:rs2232165
Natural variantVAR_032705204in GHDP; affects cell-surface expression; impairs constitutive activity; does not affect the ability to respond to ghrelin; dbSNP:rs121917883
Natural variantVAR_073173237in GHDP; results in partial loss of constitutive activity of the receptor; does not affect response to ghrelin; does not affect receptor cell-surface expression; dbSNP:rs199588904

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 511 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Keywords

Organism-specific databases

Miscellaneous

Chemistry

Genetic variation databases

PTM/Processing

Features

Showing features for chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
ChainPRO_00000694791-366Growth hormone secretagogue receptor type 1
Glycosylation13N-linked (GlcNAc...) asparagine
Glycosylation27N-linked (GlcNAc...) asparagine
Disulfide bond116↔198

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Pituitary and hypothalamus.

Gene expression databases

Organism-specific databases

Interaction

Binary interactions

Protein-protein interaction databases

Chemistry

Miscellaneous

Family & Domains

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Keywords

Phylogenomic databases

Family and domain databases

Protein family/group databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q92847-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    366
  • Mass (Da)
    41,329
  • Last updated
    1997-02-01 v1
  • Checksum
    D1B62710DA9DC0C6
MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT

Q92847-2

  • Name
    1B
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 266-289: AVVVFAFILCWLPFHVGRYLFSKS → GGSQRALRLSLAGPILSLCLLPSL
    • 290-366: Missing

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_001916266-289in isoform 1B
Alternative sequenceVSP_001917290-366in isoform 1B

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U60179
EMBL· GenBank· DDBJ
AAC50653.1
EMBL· GenBank· DDBJ
mRNA
U60181
EMBL· GenBank· DDBJ
AAC50654.1
EMBL· GenBank· DDBJ
mRNA
AF369786
EMBL· GenBank· DDBJ
AAK71539.1
EMBL· GenBank· DDBJ
Genomic DNA
AF369786
EMBL· GenBank· DDBJ
AAK71540.1
EMBL· GenBank· DDBJ
Genomic DNA
AY429112
EMBL· GenBank· DDBJ
AAR07907.1
EMBL· GenBank· DDBJ
mRNA
AY322544
EMBL· GenBank· DDBJ
AAP84357.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471052
EMBL· GenBank· DDBJ
EAW78468.1
EMBL· GenBank· DDBJ
Genomic DNA
BC069068
EMBL· GenBank· DDBJ
AAH69068.1
EMBL· GenBank· DDBJ
mRNA
BC069374
EMBL· GenBank· DDBJ
AAH69374.1
EMBL· GenBank· DDBJ
mRNA
BC113547
EMBL· GenBank· DDBJ
AAI13548.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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