Q92686 · NEUG_HUMAN
- ProteinNeurogranin
- GeneNRGN
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Acts as a 'third messenger' substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity).
Features
Showing features for site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 38 | Crucial for interaction with calmodulin | ||||
Sequence: R |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | calmodulin binding | |
Biological Process | nervous system development | |
Biological Process | signal transduction |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNeurogranin
- Short namesNg
- Alternative names
- Cleaved into 1 chains
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ92686
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 77 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for modified residue, chain, modified residue (large scale data), peptide.
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Modified residue | 1 | UniProt | N-acetylmethionine | ||||
Sequence: M | |||||||
Chain | PRO_0000159591 | 1-78 | UniProt | Neurogranin | |||
Sequence: MDCCTENACSKPDDDILDIPLDDPGANAAAAKIQASFRGHMARKKIKSGERGRKGPGPGGPGGAGVARGGAGGGPSGD | |||||||
Modified residue | 36 | UniProt | Phosphoserine; by PHK and PKC | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 36 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Peptide | PRO_0000377703 | 55-78 | UniProt | NEUG(55-78) | |||
Sequence: GPGPGGPGGAGVARGGAGGGPSGD | |||||||
Modified residue | 68 | UniProt | Citrulline; partial | ||||
Sequence: R | |||||||
Modified residue | 68 | UniProt | Omega-N-methylarginine | ||||
Sequence: R |
Post-translational modification
Phosphorylated at Ser-36 by PHK and PKC, phosphorylation prevents interaction with Calmodulin and interrupts several learning- and memory-associated functions.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
In the cerebral cortex, found in the cell bodies of neurons in layers II-VI, and in apical and basal dendrites of pyramidal neurons. Is not found in the dendrites in patients with Alzheimer disease.
Gene expression databases
Organism-specific databases
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 26-47 | IQ | ||||
Sequence: ANAAAAKIQASFRGHMARKKIK | ||||||
Region | 39-78 | Disordered | ||||
Sequence: GHMARKKIKSGERGRKGPGPGGPGGAGVARGGAGGGPSGD | ||||||
Domain | 48-78 | Collagen-like | ||||
Sequence: SGERGRKGPGPGGPGGAGVARGGAGGGPSGD |
Domain
Neurogranin is intrinsically unstructured; however, upon binding with CaM, The IQ domain adopts a helical conformation.
Sequence similarities
Belongs to the neurogranin family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length78
- Mass (Da)7,618
- Last updated1997-02-01 v1
- Checksum0D6ED790A31D5785
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
Y09689 EMBL· GenBank· DDBJ | CAA70867.1 EMBL· GenBank· DDBJ | mRNA | ||
Y15058 EMBL· GenBank· DDBJ | CAA75343.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Y15059 EMBL· GenBank· DDBJ | CAA75343.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X99076 EMBL· GenBank· DDBJ | CAA67533.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X99075 EMBL· GenBank· DDBJ | CAA67533.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U89165 EMBL· GenBank· DDBJ | AAB49458.1 EMBL· GenBank· DDBJ | mRNA | ||
AJ317956 EMBL· GenBank· DDBJ | CAC37631.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BT007325 EMBL· GenBank· DDBJ | AAP35989.1 EMBL· GenBank· DDBJ | mRNA | ||
BC002835 EMBL· GenBank· DDBJ | AAH02835.1 EMBL· GenBank· DDBJ | mRNA |