Q92633 · LPAR1_HUMAN

  • Protein
    Lysophosphatidic acid receptor 1
  • Gene
    LPAR1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Receptor for lysophosphatidic acid (LPA) (PubMed:19306925, PubMed:25025571, PubMed:26091040, PubMed:9070858).
Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G12/G13, and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels (PubMed:26091040).
Signaling triggers an increase of cytoplasmic Ca2+ levels (PubMed:19656035, PubMed:19733258, PubMed:26091040).
Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate (PubMed:19306925).
Signaling mediates activation of down-stream MAP kinases (By similarity).
Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction (PubMed:26091040).
Promotes the activation of Rho and the formation of actin stress fibers (PubMed:26091040).
Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1 (By similarity).
Through its function as LPA receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding (PubMed:18066075, PubMed:19656035, PubMed:19733258).
Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14. Promotes cell proliferation in response to LPA (By similarity).
Inhibits the intracellular ciliogenesis pathway in response to LPA and through AKT1 activation (PubMed:31204173).
Required for normal skeleton development. May play a role in osteoblast differentiation. Required for normal brain development. Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus. Plays a role in pain perception and in the initiation of neuropathic pain (By similarity).

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site39a 1-acyl-sn-glycero-3-phosphate (UniProtKB | ChEBI)
Binding site124-129a 1-acyl-sn-glycero-3-phosphate (UniProtKB | ChEBI)
Binding site210a 1-acyl-sn-glycero-3-phosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcell surface
Cellular Componentcytoplasm
Cellular Componentdendritic shaft
Cellular Componentdendritic spine
Cellular Componentendosome
Cellular ComponentGABA-ergic synapse
Cellular Componentglutamatergic synapse
Cellular Componentneuronal cell body
Cellular Componentplasma membrane
Cellular Componentpostsynaptic membrane
Cellular Componentpresynaptic membrane
Molecular FunctionG protein-coupled receptor activity
Molecular FunctionG-protein alpha-subunit binding
Molecular Functionlysophosphatidic acid binding
Molecular Functionlysophosphatidic acid receptor activity
Molecular FunctionPDZ domain binding
Biological Processadenylate cyclase-activating G protein-coupled receptor signaling pathway
Biological Processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Biological Processbleb assembly
Biological Processcalmodulin dependent kinase signaling pathway
Biological Processcell chemotaxis
Biological Processcellular response to 1-oleoyl-sn-glycerol 3-phosphate
Biological Processcellular response to oxygen levels
Biological Processcerebellum development
Biological Processcorpus callosum development
Biological ProcessG protein-coupled receptor signaling pathway
Biological Processmyelination
Biological Processnegative regulation of cAMP-mediated signaling
Biological Processnegative regulation of cilium assembly
Biological Processnegative regulation of neuron projection development
Biological Processneurogenesis
Biological Processoligodendrocyte development
Biological Processoptic nerve development
Biological Processpositive regulation of apoptotic process
Biological Processpositive regulation of canonical NF-kappaB signal transduction
Biological Processpositive regulation of cytosolic calcium ion concentration
Biological Processpositive regulation of dendritic spine development
Biological Processpositive regulation of MAPK cascade
Biological Processpositive regulation of Rho protein signal transduction
Biological Processpositive regulation of smooth muscle cell chemotaxis
Biological Processpositive regulation of stress fiber assembly
Biological Processregulation of cell shape
Biological Processregulation of metabolic process
Biological Processregulation of postsynaptic neurotransmitter receptor internalization
Biological Processregulation of synaptic vesicle cycle

Keywords

Enzyme and pathway databases

Chemistry

Names & Taxonomy

Protein names

  • Recommended name
    Lysophosphatidic acid receptor 1
  • Short names
    LPA receptor 1; LPA-1
  • Alternative names
    • Lysophosphatidic acid receptor Edg-2

Gene names

    • Name
      LPAR1
    • Synonyms
      EDG2, LPA1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q92633
  • Secondary accessions
    • B4DK36
    • O00656
    • O00722
    • P78351

Proteomes

Organism-specific databases

Subcellular Location

Cell surface
Cell membrane
; Multi-pass membrane protein
Endosome
Note: Prior to LPA treatment found predominantly at the cell surface. Internalized after LPA treatment. Colocalizes with RALA in endocytic vesicles after LPA treatment.

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-50Extracellular
Transmembrane51-75Helical; Name=1
Topological domain76-83Cytoplasmic
Transmembrane84-107Helical; Name=2
Topological domain108-121Extracellular
Transmembrane122-144Helical; Name=3
Topological domain145-163Cytoplasmic
Transmembrane164-184Helical; Name=4
Topological domain185-204Extracellular
Transmembrane205-225Helical; Name=5
Topological domain226-255Cytoplasmic
Transmembrane256-280Helical; Name=6
Topological domain281-294Extracellular
Transmembrane295-315Helical; Name=7
Topological domain316-364Cytoplasmic

Keywords

Disease & Variants

Features

Showing features for natural variant, mutagenesis.

TypeIDPosition(s)Description
Natural variantVAR_04941477in dbSNP:rs11542862
Mutagenesis85Impairs localization at the cell membrane.
Mutagenesis87Impairs localization at the cell membrane.
Mutagenesis325-326Impairs localization at the cell membrane.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 380 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Chemistry

Genetic variation databases

PTM/Processing

Features

Showing features for chain, disulfide bond, glycosylation, modified residue, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
ChainPRO_00000694171-364UniProtLysophosphatidic acid receptor 1
Disulfide bond24↔190UniProt
Glycosylation27UniProtN-linked (GlcNAc...) asparagine
Glycosylation35UniProtN-linked (GlcNAc...) asparagine
Disulfide bond188↔195UniProt
Disulfide bond284↔287UniProt
Modified residue341UniProtPhosphoserine
Modified residue (large scale data)341PRIDEPhosphoserine
Modified residue (large scale data)344PRIDEPhosphoserine
Modified residue (large scale data)346PRIDEPhosphoserine
Modified residue (large scale data)347PRIDEPhosphoserine
Modified residue351UniProtPhosphothreonine
Modified residue (large scale data)351PRIDEPhosphothreonine
Modified residue (large scale data)358PRIDEPhosphoserine
Modified residue (large scale data)362PRIDEPhosphoserine

Post-translational modification

N-glycosylated.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in many adult organs, including brain, heart, colon, small intestine, placenta, prostate, ovary, pancreas, testes, spleen, skeletal muscle, and kidney. Little or no expression in liver, lung, thymus, or peripheral blood leukocytes (PubMed:9070858).
Detected in lung fibroblasts from bronchoalveolar fluid from patients with idiopathic pulmonary fibrosis (PubMed:18066075).
Detected in bone marrow-derived mesenchymal stem cells (PubMed:19733258).

Gene expression databases

Organism-specific databases

Interaction

Subunit

Interacts with RALA and GRK2 (PubMed:19306925).
Interacts with GNAQ and GNA13. Interacts with CD14; the interaction is enhanced by exposure to bacterial lipopolysaccharide (LPS) (By similarity).

Protein-protein interaction databases

Chemistry

Miscellaneous

Family & Domains

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Keywords

Phylogenomic databases

Family and domain databases

Protein family/group databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q92633-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    364
  • Mass (Da)
    41,109
  • Last updated
    2002-12-06 v3
  • Checksum
    4CA6262FD00DFE74
MAAISTSIPVISQPQFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQRSENPTGPTEGSDRSASSLNHTILAGVHSNDHSVV

Q92633-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-15: MAAISTSIPVISQPQ → MLLLLIPAHSSVLENE

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
B1AP63B1AP63_HUMANLPAR1182

Features

Showing features for alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Alternative sequenceVSP_0570461-15in isoform 2
Sequence conflict340in Ref. 1; AAC51139

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U80811
EMBL· GenBank· DDBJ
AAC51139.1
EMBL· GenBank· DDBJ
mRNA
Y09479
EMBL· GenBank· DDBJ
CAA70686.1
EMBL· GenBank· DDBJ
mRNA
Y09479
EMBL· GenBank· DDBJ
CAA70687.1
EMBL· GenBank· DDBJ
mRNA
U78192
EMBL· GenBank· DDBJ
AAC00530.1
EMBL· GenBank· DDBJ
mRNA
AY322546
EMBL· GenBank· DDBJ
AAP84359.1
EMBL· GenBank· DDBJ
mRNA
AK296374
EMBL· GenBank· DDBJ
BAG59048.1
EMBL· GenBank· DDBJ
mRNA
AC007157
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL157881
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL442064
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC030615
EMBL· GenBank· DDBJ
AAH30615.1
EMBL· GenBank· DDBJ
mRNA
BC036034
EMBL· GenBank· DDBJ
AAH36034.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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