Q925N3 · PEX5R_RAT

  • Protein
    PEX5-related protein
  • Gene
    Pex5l
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell tip
Cellular Componentcytoplasm
Cellular Componentcytosol
Cellular Componentdendrite
Cellular Componentintracellular cyclic nucleotide activated cation channel complex
Cellular Componentperinuclear region of cytoplasm
Cellular Componentperoxisomal membrane
Cellular Componentreceptor complex
Molecular Functionintracellularly cyclic nucleotide-activated monoatomic cation channel activity
Molecular Functionperoxisome matrix targeting signal-1 binding
Molecular Functionperoxisome targeting sequence binding
Molecular Functionsmall GTPase binding
Biological Processmaintenance of protein location
Biological Processpositive regulation of corticotropin secretion
Biological Processprotein import into peroxisome matrix, docking
Biological Processregulated exocytosis
Biological Processregulation of cAMP-mediated signaling
Biological Processregulation of membrane potential

Names & Taxonomy

Protein names

  • Recommended name
    PEX5-related protein
  • Alternative names
    • PEX5-like protein
    • Peroxin-5-related protein
    • TPR-containing Rab8b-interacting protein
    • Tetratricopeptide repeat-containing Rab8b-interacting protein (Pex5Rp; TRIP8b)

Gene names

    • Name
      Pex5l
    • Synonyms
      Pex2, Pex5r, Trip8b

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    Q925N3

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00001063191-602
Modified residue181Phosphoserine
Modified residue229Phosphoserine
Modified residue233Phosphoserine
Modified residue237Phosphoserine
Modified residue421Phosphoserine
Modified residue423Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Brain specific.

Interaction

Subunit

Forms an obligate 4:4 complex with HCN2 (By similarity).
Interacts with RAB8B (PubMed:11278749).
Interacts with HCN3 (By similarity).
Interacts with HCN4 with a 4:4 HCN4:PEX5L stoichiometry; reduces the effects of cAMP on the voltage-dependence and rate of activation of HCN4 (By similarity).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias, repeat.

TypeIDPosition(s)Description
Region94-140Disordered
Compositional bias107-123Basic and acidic residues
Compositional bias167-189Basic and acidic residues
Region167-206Disordered
Compositional bias190-206Polar residues
Repeat302-335TPR 1
Repeat336-369TPR 2
Repeat371-403TPR 3
Repeat450-483TPR 4
Repeat485-517TPR 5
Repeat519-551TPR 6

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    602
  • Mass (Da)
    66,872
  • Last updated
    2001-12-01 v1
  • Checksum
    5B8841F2AE1D558F
MYQGHMQGKGSRAADKAVAMVMKEIPREESAEEKPLLTMTSQLVNEQQESRPLLSPSIDDFLCETKSEAIAKPVTSNTAVLTTGLDLLDLSEPVSQTQTKAKKSESSSKSSSLKKKADGSDLISADAEQRAQALRGPETSSLDLDIQTQLEKWDDVKFHGDRTSKGHLMAERKSCSSRAGSKELLWSSEHRSQPELSTGKSALNSESASELELVAPAQARLTKEHRWGSALLSRNHSLEEEFERAKAAVESDTEFWDKMQAEWEEMARRNWISENQEAQNQVTVSASEKGYYFHTENPFKDWPGAFEEGLKRLKEGDLPVTILFMEAAILQDPGNAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTSHQQDACEALKNWIKQNPKYKYLVKNKKGSPGLTRRMSKSPVDSSVLEGVKDLYLEAAHQNGDMIDPDLQTGLGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYNLGISCINLGAYREAVSNFLTALSLQRKSRNQQQVPHPAISGNIWAALRIALSLMDQPELFQAANLGDLDVLLRAFNLDP

Computationally mapped potential isoform sequences

There are 8 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8I6AHG5A0A8I6AHG5_RATPex5l648
A0A8I6AGZ2A0A8I6AGZ2_RATPex5l567
A0A8I6AHT0A0A8I6AHT0_RATPex5l602
F1LMT5F1LMT5_RATPex5l613
A0A8I6AMT2A0A8I6AMT2_RATPex5l591
A0A8I6B1I9A0A8I6B1I9_RATPex5l624
A0A8I6A617A0A8I6A617_RATPex5l615
A0A8I6G884A0A8I6G884_RATPex5l650

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias107-123Basic and acidic residues
Compositional bias167-189Basic and acidic residues
Compositional bias190-206Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF324454
EMBL· GenBank· DDBJ
AAK38580.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp