Q925N3 · PEX5R_RAT
- ProteinPEX5-related protein
- GenePex5l
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids602 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | cell tip | |
Cellular Component | cytoplasm | |
Cellular Component | cytosol | |
Cellular Component | dendrite | |
Cellular Component | intracellular cyclic nucleotide activated cation channel complex | |
Cellular Component | perinuclear region of cytoplasm | |
Cellular Component | peroxisomal membrane | |
Cellular Component | receptor complex | |
Molecular Function | intracellularly cyclic nucleotide-activated monoatomic cation channel activity | |
Molecular Function | peroxisome matrix targeting signal-1 binding | |
Molecular Function | peroxisome targeting sequence binding | |
Molecular Function | small GTPase binding | |
Biological Process | maintenance of protein location | |
Biological Process | positive regulation of corticotropin secretion | |
Biological Process | protein import into peroxisome matrix, docking | |
Biological Process | regulated exocytosis | |
Biological Process | regulation of cAMP-mediated signaling | |
Biological Process | regulation of membrane potential |
Names & Taxonomy
Protein names
- Recommended namePEX5-related protein
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionQ925N3
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000106319 | 1-602 | PEX5-related protein | |||
Sequence: MYQGHMQGKGSRAADKAVAMVMKEIPREESAEEKPLLTMTSQLVNEQQESRPLLSPSIDDFLCETKSEAIAKPVTSNTAVLTTGLDLLDLSEPVSQTQTKAKKSESSSKSSSLKKKADGSDLISADAEQRAQALRGPETSSLDLDIQTQLEKWDDVKFHGDRTSKGHLMAERKSCSSRAGSKELLWSSEHRSQPELSTGKSALNSESASELELVAPAQARLTKEHRWGSALLSRNHSLEEEFERAKAAVESDTEFWDKMQAEWEEMARRNWISENQEAQNQVTVSASEKGYYFHTENPFKDWPGAFEEGLKRLKEGDLPVTILFMEAAILQDPGNAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTSHQQDACEALKNWIKQNPKYKYLVKNKKGSPGLTRRMSKSPVDSSVLEGVKDLYLEAAHQNGDMIDPDLQTGLGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYNLGISCINLGAYREAVSNFLTALSLQRKSRNQQQVPHPAISGNIWAALRIALSLMDQPELFQAANLGDLDVLLRAFNLDP | ||||||
Modified residue | 181 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 229 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 233 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 237 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 421 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 423 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Brain specific.
Interaction
Subunit
Forms an obligate 4:4 complex with HCN2 (By similarity).
Interacts with RAB8B (PubMed:11278749).
Interacts with HCN3 (By similarity).
Interacts with HCN4 with a 4:4 HCN4:PEX5L stoichiometry; reduces the effects of cAMP on the voltage-dependence and rate of activation of HCN4 (By similarity).
Interacts with RAB8B (PubMed:11278749).
Interacts with HCN3 (By similarity).
Interacts with HCN4 with a 4:4 HCN4:PEX5L stoichiometry; reduces the effects of cAMP on the voltage-dependence and rate of activation of HCN4 (By similarity).
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 94-140 | Disordered | ||||
Sequence: VSQTQTKAKKSESSSKSSSLKKKADGSDLISADAEQRAQALRGPETS | ||||||
Compositional bias | 107-123 | Basic and acidic residues | ||||
Sequence: SSKSSSLKKKADGSDLI | ||||||
Compositional bias | 167-189 | Basic and acidic residues | ||||
Sequence: HLMAERKSCSSRAGSKELLWSSE | ||||||
Region | 167-206 | Disordered | ||||
Sequence: HLMAERKSCSSRAGSKELLWSSEHRSQPELSTGKSALNSE | ||||||
Compositional bias | 190-206 | Polar residues | ||||
Sequence: HRSQPELSTGKSALNSE | ||||||
Repeat | 302-335 | TPR 1 | ||||
Sequence: WPGAFEEGLKRLKEGDLPVTILFMEAAILQDPGN | ||||||
Repeat | 336-369 | TPR 2 | ||||
Sequence: AEAWQFLGITQAENENEQAAIVALQRCLELQPNN | ||||||
Repeat | 371-403 | TPR 3 | ||||
Sequence: KALMALAVSYTNTSHQQDACEALKNWIKQNPKY | ||||||
Repeat | 450-483 | TPR 4 | ||||
Sequence: PDLQTGLGVLFHLSGEFNRAIDAFNAALTVRPED | ||||||
Repeat | 485-517 | TPR 5 | ||||
Sequence: SLWNRLGATLANGDRSEEAVEAYTRALEIQPGF | ||||||
Repeat | 519-551 | TPR 6 | ||||
Sequence: RSRYNLGISCINLGAYREAVSNFLTALSLQRKS |
Sequence similarities
Belongs to the peroxisomal targeting signal receptor family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length602
- Mass (Da)66,872
- Last updated2001-12-01 v1
- Checksum5B8841F2AE1D558F
Computationally mapped potential isoform sequences
There are 8 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8I6AHG5 | A0A8I6AHG5_RAT | Pex5l | 648 | ||
A0A8I6AGZ2 | A0A8I6AGZ2_RAT | Pex5l | 567 | ||
A0A8I6AHT0 | A0A8I6AHT0_RAT | Pex5l | 602 | ||
F1LMT5 | F1LMT5_RAT | Pex5l | 613 | ||
A0A8I6AMT2 | A0A8I6AMT2_RAT | Pex5l | 591 | ||
A0A8I6B1I9 | A0A8I6B1I9_RAT | Pex5l | 624 | ||
A0A8I6A617 | A0A8I6A617_RAT | Pex5l | 615 | ||
A0A8I6G884 | A0A8I6G884_RAT | Pex5l | 650 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 107-123 | Basic and acidic residues | ||||
Sequence: SSKSSSLKKKADGSDLI | ||||||
Compositional bias | 167-189 | Basic and acidic residues | ||||
Sequence: HLMAERKSCSSRAGSKELLWSSE | ||||||
Compositional bias | 190-206 | Polar residues | ||||
Sequence: HRSQPELSTGKSALNSE |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF324454 EMBL· GenBank· DDBJ | AAK38580.1 EMBL· GenBank· DDBJ | mRNA |