Q92482 · AQP3_HUMAN

  • Protein
    Aquaporin-3
  • Gene
    AQP3
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Water channel required to promote glycerol permeability and water transport across cell membranes (PubMed:12239222, PubMed:30420639).
Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentbasolateral plasma membrane
Cellular Componentcell-cell junction
Cellular Componentcytoplasm
Cellular Componentmembrane
Cellular Componentnucleoplasm
Cellular Componentplasma membrane
Molecular Functionglycerol channel activity
Molecular Functionidentical protein binding
Molecular Functionurea transmembrane transporter activity
Molecular Functionwater channel activity
Biological Processcellular response to hypoxia
Biological Processestablishment of localization in cell
Biological Processglycerol transmembrane transport
Biological Processodontogenesis
Biological Processpositive regulation of immune system process
Biological Processregulation of keratinocyte differentiation
Biological Processrenal water absorption
Biological Processrenal water homeostasis
Biological Processresponse to calcium ion
Biological Processresponse to ischemia
Biological Processresponse to retinoic acid
Biological Processresponse to vitamin D
Biological Processwater transport

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Aquaporin-3
  • Short names
    AQP-3
  • Alternative names
    • Aquaglyceroporin-3

Gene names

    • Name
      AQP3

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q92482
  • Secondary accessions
    • A8K843
    • B2RE16
    • D3DRL3
    • O00108
    • Q6FGT2
    • Q6FGW6

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Basolateral cell membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, transmembrane, intramembrane.

TypeIDPosition(s)Description
Topological domain1-26Cytoplasmic
Transmembrane27-47Helical
Topological domain48-53Extracellular
Transmembrane54-74Helical
Topological domain75-78Cytoplasmic
Intramembrane79-92Discontinuously helical
Topological domain93-98Cytoplasmic
Transmembrane99-123Helical
Topological domain124-157Extracellular
Transmembrane158-178Helical
Topological domain179-188Cytoplasmic
Transmembrane189-208Helical
Intramembrane209-227Discontinuously helical
Topological domain228-244Extracellular
Transmembrane245-265Helical
Topological domain266-292Cytoplasmic

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_02508943in dbSNP:rs34942735

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 280 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Chemistry

Genetic variation databases

PTM/Processing

Features

Showing features for chain, glycosylation.

TypeIDPosition(s)Description
ChainPRO_00000639431-292Aquaporin-3
Glycosylation141N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Widely expressed in epithelial cells of kidney (collecting ducts) and airways, in keratinocytes, immature dendritic cells and erythrocytes. Isoform 2 is not detectable in erythrocytes at the protein level.

Induction

Up-regulated by magnesium.

Gene expression databases

Organism-specific databases

Interaction

Binary interactions

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for motif.

TypeIDPosition(s)Description
Motif83-85NPA 1
Motif215-217NPA 2

Domain

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similarities

Belongs to the MIP/aquaporin (TC 1.A.8) family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q92482-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    292
  • Mass (Da)
    31,544
  • Last updated
    1997-11-01 v2
  • Checksum
    A9555E9576EABA9C
MGRQKELVSRCGEMLHIRYRLLRQALAECLGTLILVMFGCGSVAQVVLSRGTHGGFLTINLAFGFAVTLGILIAGQVSGAHLNPAVTFAMCFLAREPWIKLPIYTLAQTLGAFLGAGIVFGLYYDAIWHFADNQLFVSGPNGTAGIFATYPSGHLDMINGFFDQFIGTASLIVCVLAIVDPYNNPVPRGLEAFTVGLVVLVIGTSMGFNSGYAVNPARDFGPRLFTALAGWGSAVFTTGQHWWWVPIVSPLLGSIAGVFVYQLMIGCHLEQPPPSNEEENVKLAHVKHKEQI

Q92482-2

  • Name
    2
  • Synonyms
    delta5
  • Note
    Due to a polymorphism at the 5'-splice donor site of intron 5, leading to exon 5 skipping and premature termination of translation. This is the molecular basis of the GIL blood group.
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 165-281: FIGTASLIVCVLAIVDPYNNPVPRGLEAFTVGLVVLVIGTSMGFNSGYAVNPARDFGPRLFTALAGWGSAVFTTGQHWWWVPIVSPLLGSIAGVFVYQLMIGCHLEQPPPSNEEENV → DRPALVVGAHRVPTPGLHCGCLRVPADDRLPPGAAPTLQRGRECEAGPCEAQGADLSGKGHLPLRCPGLEHPLTVQGHSQEAPLHDPPFQAKELPIYPHPTKTAPSGFPLDLAQIAP
    • 282-292: Missing

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A2R8Y2R4A0A2R8Y2R4_HUMANAQP3237
A0A2R8YDV4A0A2R8YDV4_HUMANAQP3155
A0A2R8YD22A0A2R8YD22_HUMANAQP3102

Features

Showing features for sequence conflict, alternative sequence.

TypeIDPosition(s)Description
Sequence conflict23in Ref. 6; BAF84897
Sequence conflict137in Ref. 4; CAG46822
Alternative sequenceVSP_003229165-281in isoform 2
Alternative sequenceVSP_003230282-292in isoform 2

Polymorphism

AQP3 is responsible for the GIL blood group system. Isoform 2 is detected in GIL-negative individuals that lack functional AQP3.

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB001325
EMBL· GenBank· DDBJ
BAA19237.1
EMBL· GenBank· DDBJ
mRNA
AJ493597
EMBL· GenBank· DDBJ
CAD38526.1
EMBL· GenBank· DDBJ
mRNA
CR541991
EMBL· GenBank· DDBJ
CAG46788.1
EMBL· GenBank· DDBJ
mRNA
CR542025
EMBL· GenBank· DDBJ
CAG46822.1
EMBL· GenBank· DDBJ
mRNA
BT007199
EMBL· GenBank· DDBJ
AAP35863.1
EMBL· GenBank· DDBJ
mRNA
AK292208
EMBL· GenBank· DDBJ
BAF84897.1
EMBL· GenBank· DDBJ
mRNA
AK315760
EMBL· GenBank· DDBJ
BAG38113.1
EMBL· GenBank· DDBJ
mRNA
DQ083949
EMBL· GenBank· DDBJ
AAY68214.1
EMBL· GenBank· DDBJ
Genomic DNA
AL356218
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471071
EMBL· GenBank· DDBJ
EAW58500.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471071
EMBL· GenBank· DDBJ
EAW58504.1
EMBL· GenBank· DDBJ
Genomic DNA
BC013566
EMBL· GenBank· DDBJ
AAH13566.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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