Q92482 · AQP3_HUMAN
- ProteinAquaporin-3
- GeneAQP3
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids292 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Water channel required to promote glycerol permeability and water transport across cell membranes (PubMed:12239222, PubMed:30420639).
Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism (By similarity).
Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | basolateral plasma membrane | |
Cellular Component | cell-cell junction | |
Cellular Component | cytoplasm | |
Cellular Component | membrane | |
Cellular Component | nucleoplasm | |
Cellular Component | plasma membrane | |
Molecular Function | glycerol channel activity | |
Molecular Function | identical protein binding | |
Molecular Function | urea transmembrane transporter activity | |
Molecular Function | water channel activity | |
Biological Process | cellular response to hypoxia | |
Biological Process | establishment of localization in cell | |
Biological Process | glycerol transmembrane transport | |
Biological Process | odontogenesis | |
Biological Process | positive regulation of immune system process | |
Biological Process | regulation of keratinocyte differentiation | |
Biological Process | renal water absorption | |
Biological Process | renal water homeostasis | |
Biological Process | response to calcium ion | |
Biological Process | response to ischemia | |
Biological Process | response to retinoic acid | |
Biological Process | response to vitamin D | |
Biological Process | water transport |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameAquaporin-3
- Short namesAQP-3
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ92482
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Basolateral cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane, intramembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-26 | Cytoplasmic | ||||
Sequence: MGRQKELVSRCGEMLHIRYRLLRQAL | ||||||
Transmembrane | 27-47 | Helical | ||||
Sequence: AECLGTLILVMFGCGSVAQVV | ||||||
Topological domain | 48-53 | Extracellular | ||||
Sequence: LSRGTH | ||||||
Transmembrane | 54-74 | Helical | ||||
Sequence: GGFLTINLAFGFAVTLGILIA | ||||||
Topological domain | 75-78 | Cytoplasmic | ||||
Sequence: GQVS | ||||||
Intramembrane | 79-92 | Discontinuously helical | ||||
Sequence: GAHLNPAVTFAMCF | ||||||
Topological domain | 93-98 | Cytoplasmic | ||||
Sequence: LAREPW | ||||||
Transmembrane | 99-123 | Helical | ||||
Sequence: IKLPIYTLAQTLGAFLGAGIVFGLY | ||||||
Topological domain | 124-157 | Extracellular | ||||
Sequence: YDAIWHFADNQLFVSGPNGTAGIFATYPSGHLDM | ||||||
Transmembrane | 158-178 | Helical | ||||
Sequence: INGFFDQFIGTASLIVCVLAI | ||||||
Topological domain | 179-188 | Cytoplasmic | ||||
Sequence: VDPYNNPVPR | ||||||
Transmembrane | 189-208 | Helical | ||||
Sequence: GLEAFTVGLVVLVIGTSMGF | ||||||
Intramembrane | 209-227 | Discontinuously helical | ||||
Sequence: NSGYAVNPARDFGPRLFTA | ||||||
Topological domain | 228-244 | Extracellular | ||||
Sequence: LAGWGSAVFTTGQHWWW | ||||||
Transmembrane | 245-265 | Helical | ||||
Sequence: VPIVSPLLGSIAGVFVYQLMI | ||||||
Topological domain | 266-292 | Cytoplasmic | ||||
Sequence: GCHLEQPPPSNEEENVKLAHVKHKEQI |
Keywords
- Cellular component
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_025089 | 43 | in dbSNP:rs34942735 | |||
Sequence: V → M |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 280 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000063943 | 1-292 | Aquaporin-3 | |||
Sequence: MGRQKELVSRCGEMLHIRYRLLRQALAECLGTLILVMFGCGSVAQVVLSRGTHGGFLTINLAFGFAVTLGILIAGQVSGAHLNPAVTFAMCFLAREPWIKLPIYTLAQTLGAFLGAGIVFGLYYDAIWHFADNQLFVSGPNGTAGIFATYPSGHLDMINGFFDQFIGTASLIVCVLAIVDPYNNPVPRGLEAFTVGLVVLVIGTSMGFNSGYAVNPARDFGPRLFTALAGWGSAVFTTGQHWWWVPIVSPLLGSIAGVFVYQLMIGCHLEQPPPSNEEENVKLAHVKHKEQI | ||||||
Glycosylation | 141 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Widely expressed in epithelial cells of kidney (collecting ducts) and airways, in keratinocytes, immature dendritic cells and erythrocytes. Isoform 2 is not detectable in erythrocytes at the protein level.
Induction
Up-regulated by magnesium.
Gene expression databases
Organism-specific databases
Interaction
Binary interactions
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Motif | 83-85 | NPA 1 | ||||
Sequence: NPA | ||||||
Motif | 215-217 | NPA 2 | ||||
Sequence: NPA |
Domain
Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
Sequence similarities
Belongs to the MIP/aquaporin (TC 1.A.8) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q92482-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length292
- Mass (Da)31,544
- Last updated1997-11-01 v2
- ChecksumA9555E9576EABA9C
Q92482-2
- Name2
- Synonymsdelta5
- NoteDue to a polymorphism at the 5'-splice donor site of intron 5, leading to exon 5 skipping and premature termination of translation. This is the molecular basis of the GIL blood group.
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2R8Y2R4 | A0A2R8Y2R4_HUMAN | AQP3 | 237 | ||
A0A2R8YDV4 | A0A2R8YDV4_HUMAN | AQP3 | 155 | ||
A0A2R8YD22 | A0A2R8YD22_HUMAN | AQP3 | 102 |
Features
Showing features for sequence conflict, alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 23 | in Ref. 6; BAF84897 | ||||
Sequence: R → G | ||||||
Sequence conflict | 137 | in Ref. 4; CAG46822 | ||||
Sequence: V → A | ||||||
Alternative sequence | VSP_003229 | 165-281 | in isoform 2 | |||
Sequence: FIGTASLIVCVLAIVDPYNNPVPRGLEAFTVGLVVLVIGTSMGFNSGYAVNPARDFGPRLFTALAGWGSAVFTTGQHWWWVPIVSPLLGSIAGVFVYQLMIGCHLEQPPPSNEEENV → DRPALVVGAHRVPTPGLHCGCLRVPADDRLPPGAAPTLQRGRECEAGPCEAQGADLSGKGHLPLRCPGLEHPLTVQGHSQEAPLHDPPFQAKELPIYPHPTKTAPSGFPLDLAQIAP | ||||||
Alternative sequence | VSP_003230 | 282-292 | in isoform 2 | |||
Sequence: Missing |
Polymorphism
AQP3 is responsible for the GIL blood group system. Isoform 2 is detected in GIL-negative individuals that lack functional AQP3.
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB001325 EMBL· GenBank· DDBJ | BAA19237.1 EMBL· GenBank· DDBJ | mRNA | ||
AJ493597 EMBL· GenBank· DDBJ | CAD38526.1 EMBL· GenBank· DDBJ | mRNA | ||
CR541991 EMBL· GenBank· DDBJ | CAG46788.1 EMBL· GenBank· DDBJ | mRNA | ||
CR542025 EMBL· GenBank· DDBJ | CAG46822.1 EMBL· GenBank· DDBJ | mRNA | ||
BT007199 EMBL· GenBank· DDBJ | AAP35863.1 EMBL· GenBank· DDBJ | mRNA | ||
AK292208 EMBL· GenBank· DDBJ | BAF84897.1 EMBL· GenBank· DDBJ | mRNA | ||
AK315760 EMBL· GenBank· DDBJ | BAG38113.1 EMBL· GenBank· DDBJ | mRNA | ||
DQ083949 EMBL· GenBank· DDBJ | AAY68214.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AL356218 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471071 EMBL· GenBank· DDBJ | EAW58500.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471071 EMBL· GenBank· DDBJ | EAW58504.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC013566 EMBL· GenBank· DDBJ | AAH13566.1 EMBL· GenBank· DDBJ | mRNA |