Q92331 · VPS5_YEAST

Function

function

Plays a role in vesicular protein sorting. Required for retention of late Golgi membrane proteins and vacuolar biogenesis. Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport. The VPS5-VPS17 subcomplex may assemble onto the membrane to promote vesicle formation.

Miscellaneous

Present with 6120 molecules/cell in log phase SD medium.

Features

Showing features for binding site.

167550100150200250300350400450500550600650
TypeIDPosition(s)Description
Binding site320a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) (UniProtKB | ChEBI)
Binding site346a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) (UniProtKB | ChEBI)
Binding site360a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentendomembrane system
Cellular Componentendosome
Cellular Componentendosome membrane
Cellular ComponentGolgi membrane
Cellular Componentretromer complex
Cellular Componentretromer, tubulation complex
Molecular Functionphosphatidylinositol binding
Molecular Functionphosphatidylinositol-3-phosphate binding
Biological Processendocytic recycling
Biological Processprotein retention in Golgi apparatus
Biological Processprotein transport
Biological Processretrograde transport, endosome to Golgi

Keywords

Enzyme and pathway databases

Protein family/group databases

    • 9.A.63.1.1the retromer-dependent vacuolar protein sorting (r-vps) family

Names & Taxonomy

Protein names

  • Recommended name
    Vacuolar protein sorting-associated protein 5
  • Alternative names
    • Carboxypeptidase Y-deficient protein 10
    • Vacuolar protein-targeting protein 5

Gene names

    • Name
      VPS5
    • Synonyms
      GRD2, PEP10, VPT5
    • ORF names
      YOR29-20
    • Ordered locus names
      YOR069W

Organism names

Accessions

  • Primary accession
    Q92331
  • Secondary accessions
    • D6W2D1
    • E9P8U6
    • Q08483

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002138041-675Vacuolar protein sorting-associated protein 5

Post-translational modification

Phosphorylated on serine residue(s).

Keywords

Proteomic databases

PTM databases

Interaction

Subunit

Component of the retromer complex which consists of VPS29, VPS26, VPS35, VPS5 and VPS17. Component of a retromer subcomplex consisting of VPSD5 and VPS17.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q92331PEP8 P403353EBI-20483, EBI-20373
BINARY Q92331VPS17 P329138EBI-20483, EBI-20366
BINARY Q92331VPS35 P341104EBI-20483, EBI-20415

Complex viewer

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region1-26Disordered
Region65-84Disordered
Region165-219Disordered
Compositional bias191-219Basic and acidic residues
Domain279-394PX

Domain

The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization.

Sequence similarities

Belongs to the sorting nexin family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    675
  • Mass (Da)
    76,484
  • Last updated
    1997-02-01 v1
  • Checksum
    FBBA994EADBDC2BD
MDYEDNLEAPVWDELNHEGDKTQSLVSNSIESIGQISTNEERKDNELLETTASFADKIDLDSAPEWKDPGLSVAGNPQLEEHDNSKADDLINSLAPEQDPIADLKNSTTQFIATRESGGALFTGNANSPLVFDDTIYDANTSPNTSKSISGRRSGKPRILFDSARAQRNSKRNHSLKAKRTTASDDTIKTPFTDPLKKAEKENEFVEEPLDDRNERRENNEGKFTASVEKNILEQVDRPLYNLPQTGANISSPAEVEENSEKFGKTKIGSKVPPTEKAVAFKVEVKDPVKVGELTSIHVEYTVISESSLLELKYAQVSRRYRDFRWLYRQLQNNHWGKVIPPPPEKQSVGSFKENFIENRRFQMESMLKKICQDPVLQKDKDFLLFLTSDDFSSESKKRAFLTGSGAINDSNDLSEVRISEIQLLGAEDAAEVLKNGGIDAESHKGFMSISFSSLPKYNEADEFFIEKKQKIDELEDNLKKLSKSLEMVDTSRNTLAASTEEFSSMVETLASLNVSEPNSELLNNFADVHKSIKSSLERSSLQETLTMGVMLDDYIRSLASVKAIFNQRSKLGYFLVVIENDMNKKHSQLGKLGQNIHSEKFREMRKEFQTLERRYNLTKKQWQAVGDKIKDEFQGFSTDKIREFRNGMEISLEAAIESQKECIELWETFYQTNL

Sequence caution

The sequence CAA94554.1 differs from that shown. Reason: Frameshift
The sequence CAA99262.1 differs from that shown. Reason: Erroneous initiation
The sequence Z74976 differs from that shown. Reason: Frameshift

Features

Showing features for compositional bias, sequence conflict.

TypeIDPosition(s)Description
Compositional bias191-219Basic and acidic residues
Sequence conflict376in Ref. 6; AAS56361

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U73512
EMBL· GenBank· DDBJ
AAB62976.1
EMBL· GenBank· DDBJ
Genomic DNA
U84735
EMBL· GenBank· DDBJ
AAB41798.1
EMBL· GenBank· DDBJ
Genomic DNA
Z70678
EMBL· GenBank· DDBJ
CAA94554.1
EMBL· GenBank· DDBJ
Genomic DNA Frameshift
Z74976
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
Z74977
EMBL· GenBank· DDBJ
CAA99262.1
EMBL· GenBank· DDBJ
Genomic DNA Different initiation
AY558035
EMBL· GenBank· DDBJ
AAS56361.1
EMBL· GenBank· DDBJ
Genomic DNA
BK006948
EMBL· GenBank· DDBJ
DAA10847.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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