Q92317 · NCB2_YEAST

Function

function

Component of the NC2 complex which represses RNA polymerase II transcription through binding to SPT15/TBP and thereby inhibiting the assembly of the preinitiation complex. The NC2 complex may also mediate transcriptional activation from TATA-driven promoters through association with SPT15/TBP.

Miscellaneous

Present with 2950 molecules/cell in log phase SD medium.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnegative cofactor 2 complex
Cellular Componentnucleus
Molecular Functionchromatin binding
Molecular Functioncore promoter sequence-specific DNA binding
Molecular Functionprotein heterodimerization activity
Molecular FunctionRNA polymerase II general transcription initiation factor activity
Molecular Functiontranscription corepressor activity
Biological Processcellular response to heat
Biological Processnegative regulation of RNA polymerase II transcription preinitiation complex assembly
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processnegative regulation of transcription by RNA polymerase III
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processregulation of RNA polymerase II transcription preinitiation complex assembly
Biological ProcessRNA polymerase II preinitiation complex assembly

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Negative cofactor 2 complex subunit beta
  • Short names
    NC2 complex subunit beta
  • Alternative names
    • Transcriptional repressor YDR1

Gene names

    • Name
      NCB2
    • Synonyms
      YDR1
    • Ordered locus names
      YDR397C

Organism names

Accessions

  • Primary accession
    Q92317
  • Secondary accessions
    • D6VT30
    • O00064
    • P87340
    • Q04176

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00002552681-146Negative cofactor 2 complex subunit beta
Modified residue135Phosphoserine
Modified residue137Phosphoserine
Modified residue142Phosphoserine

Keywords

Proteomic databases

PTM databases

Interaction

Subunit

Component of the NC2 (negative cofactor 2) complex composed of BUR6 and NCB2. The NC2 complex associates with SPT15/TBP. Interacts with SPT15/TBP.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q92317BUR6 P400966EBI-37723, EBI-11908
View interactors in UniProtKB
View CPX-1662 in Complex Portal

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region124-146Disordered

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    146
  • Mass (Da)
    16,650
  • Last updated
    1997-02-01 v1
  • Checksum
    E04EB0D6F7E8D91D
MAGDSDNVSLPKATVQKMISEILDQDLMFTKDAREIIINSGIEFIMILSSMASEMADNEAKKTIAPEHVIKALEELEYNEFIPFLEEILLNFKGSQKVKETRDSKFKKSGLSEEELLRQQEELFRQSRSRLHHNSVSDPVKSEDSS

Sequence caution

The sequence AAB64838.1 differs from that shown. Reason: Erroneous gene model prediction

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U91948
EMBL· GenBank· DDBJ
AAB51375.1
EMBL· GenBank· DDBJ
Genomic DNA
Y09266
EMBL· GenBank· DDBJ
CAA70461.1
EMBL· GenBank· DDBJ
mRNA
U32274
EMBL· GenBank· DDBJ
AAB64838.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
BK006938
EMBL· GenBank· DDBJ
DAA12240.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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