Q921Q6 · Q921Q6_MOUSE
- ProteinEctonucleoside triphosphate diphosphohydrolase 1
- GeneEntpd1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids510 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
Catalytic activity
- 2 H2O + ITP = 2 H+ + IMP + 2 phosphateThis reaction proceeds in the forward direction.
- 2 H2O + UTP = 2 H+ + 2 phosphate + UMPThis reaction proceeds in the forward direction.
- ADP + H2O = AMP + H+ + phosphateThis reaction proceeds in the forward direction.
- ATP + 2 H2O = AMP + 2 H+ + 2 phosphateThis reaction proceeds in the forward direction.
- ATP + H2O = ADP + H+ + phosphateThis reaction proceeds in the forward direction.
- CDP + H2O = CMP + H+ + phosphateThis reaction proceeds in the forward direction.
- CTP + 2 H2O = CMP + 2 H+ + 2 phosphateThis reaction proceeds in the forward direction.
- CTP + H2O = CDP + H+ + phosphateThis reaction proceeds in the forward direction.
- GDP + H2O = GMP + H+ + phosphateThis reaction proceeds in the forward direction.
- GTP + 2 H2O = GMP + 2 H+ + 2 phosphateThis reaction proceeds in the forward direction.
- GTP + H2O = GDP + H+ + phosphateThis reaction proceeds in the forward direction.
- H2O + IDP = H+ + IMP + phosphateThis reaction proceeds in the forward direction.
- H2O + ITP = H+ + IDP + phosphateThis reaction proceeds in the forward direction.
- H2O + UDP = H+ + phosphate + UMPThis reaction proceeds in the forward direction.
- H2O + UTP = H+ + phosphate + UDPThis reaction proceeds in the forward direction.
- a ribonucleoside 5'-diphosphate + H2O = a ribonucleoside 5'-phosphate + H+ + phosphateThis reaction proceeds in the forward direction.
- a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + H+ + phosphateThis reaction proceeds in the forward direction.
Cofactor
Protein has several cofactor binding sites:
Features
Showing features for active site, binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Molecular Function | ATP binding | |
Molecular Function | pyrophosphatase activity |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameEctonucleoside triphosphate diphosphohydrolase 1
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ921Q6
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 17-37 | Helical | ||||
Sequence: ILIILGFTSILAVIALIAVGL | ||||||
Transmembrane | 477-499 | Helical | ||||
Sequence: YIGLMVLFSLLLVAVAITGLFIY |
Keywords
- Cellular component
Interaction
Subunit
Homodimer; disulfide-linked.
Structure
Sequence
- Sequence statusComplete
- Length510
- Mass (Da)57,176
- Last updated2001-12-01 v1
- ChecksumE77BB644AE1413A0