Q921N6 · DDX27_MOUSE

  • Protein
    Probable ATP-dependent RNA helicase DDX27
  • Gene
    Ddx27
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Probable ATP-dependent RNA helicase. Component of the nucleolar ribosomal RNA (rRNA) processing machinery that regulates 3' end formation of ribosomal 47S rRNA.

Catalytic activity

Features

Showing features for binding site.

1760100200300400500600700
TypeIDPosition(s)Description
Binding site228-235ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentchromosome
Cellular Componentnucleolus
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functionnucleic acid binding
Molecular FunctionRNA helicase activity
Biological ProcessrRNA processing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable ATP-dependent RNA helicase DDX27
  • EC number
  • Alternative names
    • DEAD box protein 27

Gene names

    • Name
      Ddx27

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q921N6
  • Secondary accessions
    • Q3UUG2
    • Q8R0W3
    • Q8R1E2

Proteomes

Organism-specific databases

Subcellular Location

Nucleus, nucleolus
Chromosome
Note: Associates with 60S and 90S pre-ribosomal particles.

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00000550321-760Probable ATP-dependent RNA helicase DDX27
Modified residue23Phosphoserine
Modified residue25Phosphoserine
Modified residue48Phosphoserine
Modified residue133Phosphoserine
Modified residue144Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Associates with PeBoW complex, composed of BOP1, PES1 and WDR12. Interacts directly with BOP1 and PES1.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, motif, compositional bias, domain.

TypeIDPosition(s)Description
Region1-50Disordered
Motif55-57Required for interaction with the PEBOW complex
Region80-149Disordered
Compositional bias81-129Basic and acidic residues
Compositional bias130-144Acidic residues
Motif157-166Nuclear localization signal
Motif184-212Q motif
Domain215-389Helicase ATP-binding
Motif337-340DEAD box
Domain419-569Helicase C-terminal
Region605-624Disordered
Region679-760Disordered
Compositional bias689-722Basic and acidic residues
Compositional bias729-743Basic and acidic residues

Domain

The C-terminal domain regulates nucleolar localization.

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q921N6-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    760
  • Mass (Da)
    85,939
  • Last updated
    2011-07-27 v3
  • Checksum
    C351B13DAC1B1E0B
MLAELGFIRTIGENDEVPVEPESDSGDEEEEGPIVLGRKQKALQKNRSADFNPDFVFTEKEGMYDGSWALADVMSQLKKKRAATTLDEKIEKVRKRRKAEDKEAKSGKVEEKEGQADSDLKGQENPGEDEAGSKDEDSETDYSSEDEEILTKADTLKVKEKKKKKKGQAAGGFFEDASEYDKSLSFQDMNLSRPLLKAITAMGFKQPTPIQKACIPVGLLGKDICACAATGTGKTAAFALPVLERLIYKPRQAAVTRVLVLVPTRELGIQVHSVTKQLAQFCSITTCLAVGGLDVKSQEAALRAAPDILIATPGRLIDHLHNCPSFHLSSIEVLILDEADRMLDEYFEEQMKEIIRMCSHHRQTMLFSATMTDEVKDLASVSLKNPVRIFVNSNTDVAPFLRQEFIRIRPNREGDREAIVAALLMRTFTDHVMLFTQTKKQAHRMHILLGLLGLQVGELHGNLSQTQRLEALRRFKDEQIDILVATDVAARGLDIEGVKTVINFTMPNTVKHYVHRVGRTARAGRAGRSVSLVGEEERKMLKEIVKAAKAPVKARILPQDVILKFRDKIEKLEKDVYAVLQLEAEEKEMQQSEAQIDTAQRLLAKGKETADQEPERSWFQTKEERKKEKIAKALQEFDLALRGKKKRKKFMKDAKKKGEMTAEERSQFEILKAQMFAERLAKRNRRTKRARAMPEDEPTGPAKKQKQQQKSVFDEELTNTSKKALKQYRAGPSFEERKQSGLPRQRRGNFKSKSRYKRKK

Q921N6-2

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
H3BLJ6H3BLJ6_MOUSEDdx27310

Sequence caution

The sequence AAH11321.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.

Features

Showing features for compositional bias, alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Compositional bias81-129Basic and acidic residues
Compositional bias130-144Acidic residues
Alternative sequenceVSP_007073292in isoform 2
Alternative sequenceVSP_007074293-760in isoform 2
Sequence conflict341in Ref. 4; AAH11321
Compositional bias689-722Basic and acidic residues
Compositional bias729-743Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK134274
EMBL· GenBank· DDBJ
BAE22077.1
EMBL· GenBank· DDBJ
mRNA
AK138442
EMBL· GenBank· DDBJ
BAE23664.1
EMBL· GenBank· DDBJ
mRNA
AL591711
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH466551
EMBL· GenBank· DDBJ
EDL06495.1
EMBL· GenBank· DDBJ
Genomic DNA
BC011321
EMBL· GenBank· DDBJ
AAH11321.1
EMBL· GenBank· DDBJ
mRNA Different initiation
BC024730
EMBL· GenBank· DDBJ
AAH24730.1
EMBL· GenBank· DDBJ
mRNA
BC026381
EMBL· GenBank· DDBJ
AAH26381.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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