ATX genetic deletion from CD11b+ cells attenuated the severity of experimental autoimmune encephalomyelitis (EAE) thus proposing a pathogenic role for the ATX/LPA axis in neuroinflammatory disorders.
Data (including data from studies in transgenic/knockout mice) suggest that expression in adult brain neurons (especially in parabrachial nucleus) of both Dmbx1 and AgRP (agouti-related peptide) is important in appetite regulation leading to leanness.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.