Q91ZI8 · IOD3_MOUSE

  • Protein
    Thyroxine 5-deiodinase
  • Gene
    Dio3
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development.

Caution

It is uncertain whether Met-1 or Met-27 is the initiator.

Catalytic activity

Features

Showing features for active site.

130420406080100120140160180200220240260280300
TypeIDPosition(s)Description
Active site170

GO annotations

AspectTerm
Cellular Componentendosome membrane
Cellular Componentplasma membrane
Molecular Functionthyroxine 5'-deiodinase activity
Molecular Functionthyroxine 5-deiodinase activity
Biological Processapoptotic process
Biological Processbrown fat cell proliferation
Biological Processhormone biosynthetic process
Biological Processpositive regulation of multicellular organism growth
Biological Processresponse to hypoxia
Biological Processretinal cone cell apoptotic process
Biological Processretinal cone cell development
Biological Processthyroid hormone catabolic process
Biological Processthyroid hormone metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Thyroxine 5-deiodinase
  • EC number
  • Alternative names
    • 5DIII
    • DIOIII
    • Type 3 DI
    • Type III iodothyronine deiodinase

Gene names

    • Name
      Dio3

Organism names

  • Taxonomic identifier
  • Strains
    • 129/SvJ
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q91ZI8
  • Secondary accessions
    • G3UY28
    • Q3UKD2

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Single-pass type II membrane protein
Endosome membrane
; Single-pass type II membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-44Cytoplasmic
Transmembrane45-67Helical; Signal-anchor for type II membrane protein
Topological domain68-304Extracellular

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001543241-304Thyroxine 5-deiodinase

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Homodimer. May undergo minor heretodimerization with DIO1 and DIO2 (By similarity).

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-22Disordered
Region77-99Disordered

Sequence similarities

Belongs to the iodothyronine deiodinase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    304
  • Mass (Da)
    34,111
  • Last updated
    2014-05-14 v4
  • Checksum
    877DD709B4104A15
MPRQAASRLVVGEGEGPPGASGPAATMLRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVELNSEGEEMPPDDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVVRPDGFQSQRILDYAQGTRPLVLNFGSCTUPPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYVIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLERYDEQLHGTRPHRF

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
K3W4Q2K3W4Q2_MOUSEDio3131

Sequence caution

The sequence AAI06848.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.
The sequence AAI06849.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.
The sequence AAL23960.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.
The sequence BAE24483.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.
The sequence BAE26869.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.

Features

Showing features for non-standard residue.

TypeIDPosition(s)Description
Non-standard residue170Selenocysteine

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF426023
EMBL· GenBank· DDBJ
AAL23960.1
EMBL· GenBank· DDBJ
Genomic DNA Different initiation
AK140797
EMBL· GenBank· DDBJ
BAE24483.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AK146060
EMBL· GenBank· DDBJ
BAE26869.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AL591207
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC106847
EMBL· GenBank· DDBJ
AAI06848.1
EMBL· GenBank· DDBJ
mRNA Different initiation
BC106848
EMBL· GenBank· DDBJ
AAI06849.1
EMBL· GenBank· DDBJ
mRNA Different initiation

Genome annotation databases

Similar Proteins

Disclaimer

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