Q91ZD1 · OSR2_MOUSE
- ProteinProtein odd-skipped-related 2
- GeneOsr2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids312 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
May be involved in the development of the mandibular molar tooth germ at the bud stage.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Ligand
Names & Taxonomy
Protein names
- Recommended nameProtein odd-skipped-related 2
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ91ZD1
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
Decrease in expression of the Wnt signaling genes Dkk2, Sfrp1 and Sfrp2 and an increase in Lef1 and Tcf7 in the mandibular molar tooth mesenchyme at 13.5 dpc.
Variants
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The viewer provides 10 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000047008 | 1-312 | Protein odd-skipped-related 2 | |||
Sequence: MGSKALPAPIPLHPSLQLTNYSFLQAVNTFPAAVDHLQGLYGLSAVQTMHMNHWTLGYPSVHEITRSTITEMAAAQGLVDARFPFPSLPFATHLFHPKQGAIAHVLPALHKDRPRFDFANLAVAATQEDPPKMGDLSKLSPGLGSPISGLSKLNPDRKPSRGRLPSKTKKEFICKFCGRHFTKSYNLLIHERTHTDERPYTCDICHKAFRRQDHLRDHRYIHSKEKPFKCQECGKGFCQSRTLAVHKTLHMQESPHKCPTCGRTFNQRSNLKTHLLTHTDIKPYSCEQCGKVFRRNCDLRRHSLTHTPRQNF |
Proteomic databases
PTM databases
Expression
Developmental stage
First detected at 9.25 dpc, specifically in the mesonephric vesicles. By 10.0 dpc expression is also observed in the rostro-lateral mandibular mesenchyme immediately adjacent to the maxillary processes. In the developing limb buds it is expressed in a unique mesenchymal domain and the onset of the expression follows a distinct dorsal to ventral developmental time sequence beginning in the forelimb and then in the hindlimb. It exhibits a dynamic expression pattern during craniofacial development, in the mandibular and maxillary processes as well as the developing palate. It is also expressed at sites of epithelial-mesenchymal interactions during tooth and kidney development.
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, zinc finger.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 146-165 | Disordered | ||||
Sequence: PISGLSKLNPDRKPSRGRLP | ||||||
Zinc finger | 172-194 | C2H2-type 1 | ||||
Sequence: FICKFCGRHFTKSYNLLIHERTH | ||||||
Zinc finger | 200-222 | C2H2-type 2 | ||||
Sequence: YTCDICHKAFRRQDHLRDHRYIH | ||||||
Zinc finger | 228-250 | C2H2-type 3 | ||||
Sequence: FKCQECGKGFCQSRTLAVHKTLH | ||||||
Zinc finger | 256-278 | C2H2-type 4 | ||||
Sequence: HKCPTCGRTFNQRSNLKTHLLTH | ||||||
Zinc finger | 284-306 | C2H2-type 5 | ||||
Sequence: YSCEQCGKVFRRNCDLRRHSLTH |
Sequence similarities
Belongs to the Odd C2H2-type zinc-finger protein family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q91ZD1-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- SynonymsOSR2A
- Length312
- Mass (Da)35,454
- Last updated2001-12-01 v1
- Checksum33B4B92B1FA11D20
Q91ZD1-2
- Name2
- SynonymsOSR2B
- Differences from canonical
- 253-312: ESPHKCPTCGRTFNQRSNLKTHLLTHTDIKPYSCEQCGKVFRRNCDLRRHSLTHTPRQNF → TSSPTAASSAAKCSGETAICGGTA
Features
Showing features for sequence conflict, alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 142 | in Ref. 3; BAC34859 | ||||
Sequence: G → W | ||||||
Alternative sequence | VSP_017122 | 253-312 | in isoform 2 | |||
Sequence: ESPHKCPTCGRTFNQRSNLKTHLLTHTDIKPYSCEQCGKVFRRNCDLRRHSLTHTPRQNF → TSSPTAASSAAKCSGETAICGGTA |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF370121 EMBL· GenBank· DDBJ | AAL07364.1 EMBL· GenBank· DDBJ | mRNA | ||
AY038074 EMBL· GenBank· DDBJ | AAK74068.1 EMBL· GenBank· DDBJ | mRNA | ||
AK052147 EMBL· GenBank· DDBJ | BAC34859.1 EMBL· GenBank· DDBJ | mRNA | ||
BC013504 EMBL· GenBank· DDBJ | AAH13504.1 EMBL· GenBank· DDBJ | mRNA |