Q91ZD1 · OSR2_MOUSE

  • Protein
    Protein odd-skipped-related 2
  • Gene
    Osr2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

May be involved in the development of the mandibular molar tooth germ at the bud stage.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA-binding transcription activator activity, RNA polymerase II-specific
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Functionmetal ion binding
Molecular FunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding
Molecular Functionsequence-specific DNA binding
Biological Processbone morphogenesis
Biological Processcell differentiation
Biological Processcell population proliferation
Biological Processchondrocyte differentiation
Biological Processembryo development ending in birth or egg hatching
Biological Processembryonic digit morphogenesis
Biological Processembryonic forelimb morphogenesis
Biological Processembryonic hindlimb morphogenesis
Biological Processembryonic skeletal joint development
Biological Processembryonic skeletal joint morphogenesis
Biological Processembryonic skeletal limb joint morphogenesis
Biological Processembryonic skeletal system morphogenesis
Biological Processeyelid development in camera-type eye
Biological Processhead development
Biological Processmesonephros development
Biological Processmetanephros development
Biological Processmiddle ear morphogenesis
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processodontogenesis
Biological Processosteoblast proliferation
Biological Processpositive regulation of bone mineralization
Biological Processpositive regulation of DNA-templated transcription
Biological Processpositive regulation of epithelial cell proliferation
Biological Processpositive regulation of gastrulation
Biological Processpositive regulation of gene expression
Biological Processpositive regulation of stem cell proliferation
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processpronephros development
Biological Processregulation of transcription by RNA polymerase II
Biological Processroof of mouth development
Biological Processstem cell proliferation
Biological Processurogenital system development

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Protein odd-skipped-related 2

Gene names

    • Name
      Osr2

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • FVB/N
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q91ZD1
  • Secondary accessions
    • Q8BPV6
    • Q91V54

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

Decrease in expression of the Wnt signaling genes Dkk2, Sfrp1 and Sfrp2 and an increase in Lef1 and Tcf7 in the mandibular molar tooth mesenchyme at 13.5 dpc.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 10 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000470081-312

Proteomic databases

PTM databases

Expression

Developmental stage

First detected at 9.25 dpc, specifically in the mesonephric vesicles. By 10.0 dpc expression is also observed in the rostro-lateral mandibular mesenchyme immediately adjacent to the maxillary processes. In the developing limb buds it is expressed in a unique mesenchymal domain and the onset of the expression follows a distinct dorsal to ventral developmental time sequence beginning in the forelimb and then in the hindlimb. It exhibits a dynamic expression pattern during craniofacial development, in the mandibular and maxillary processes as well as the developing palate. It is also expressed at sites of epithelial-mesenchymal interactions during tooth and kidney development.

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region, zinc finger.

TypeIDPosition(s)Description
Region146-165Disordered
Zinc finger172-194C2H2-type 1
Zinc finger200-222C2H2-type 2
Zinc finger228-250C2H2-type 3
Zinc finger256-278C2H2-type 4
Zinc finger284-306C2H2-type 5

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q91ZD1-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    1
  • Synonyms
    OSR2A
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    312
  • Mass (Da)
    35,454
  • Last updated
    2001-12-01 v1
  • Checksum
    33B4B92B1FA11D20
MGSKALPAPIPLHPSLQLTNYSFLQAVNTFPAAVDHLQGLYGLSAVQTMHMNHWTLGYPSVHEITRSTITEMAAAQGLVDARFPFPSLPFATHLFHPKQGAIAHVLPALHKDRPRFDFANLAVAATQEDPPKMGDLSKLSPGLGSPISGLSKLNPDRKPSRGRLPSKTKKEFICKFCGRHFTKSYNLLIHERTHTDERPYTCDICHKAFRRQDHLRDHRYIHSKEKPFKCQECGKGFCQSRTLAVHKTLHMQESPHKCPTCGRTFNQRSNLKTHLLTHTDIKPYSCEQCGKVFRRNCDLRRHSLTHTPRQNF

Q91ZD1-2

  • Name
    2
  • Synonyms
    OSR2B
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 253-312: ESPHKCPTCGRTFNQRSNLKTHLLTHTDIKPYSCEQCGKVFRRNCDLRRHSLTHTPRQNF → TSSPTAASSAAKCSGETAICGGTA

Features

Showing features for sequence conflict, alternative sequence.

TypeIDPosition(s)Description
Sequence conflict142in Ref. 3; BAC34859
Alternative sequenceVSP_017122253-312in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF370121
EMBL· GenBank· DDBJ
AAL07364.1
EMBL· GenBank· DDBJ
mRNA
AY038074
EMBL· GenBank· DDBJ
AAK74068.1
EMBL· GenBank· DDBJ
mRNA
AK052147
EMBL· GenBank· DDBJ
BAC34859.1
EMBL· GenBank· DDBJ
mRNA
BC013504
EMBL· GenBank· DDBJ
AAH13504.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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