Q91Z92 · B3GT6_MOUSE
- ProteinBeta-1,3-galactosyltransferase 6
- GeneB3galt6
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids325 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-linked galactose residue. Has a preference for galactose-beta-1,4-xylose that is found in the linker region of glycosaminoglycans, such as heparan sulfate and chondroitin sulfate. Has no activity towards substrates with terminal glucosamine or galactosamine residues.
Catalytic activity
- 3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose = 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H+ + UDPThis reaction proceeds in the forward direction.
Cofactor
Pathway
Glycan metabolism; chondroitin sulfate biosynthesis.
Glycan metabolism; heparan sulfate biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | Golgi apparatus | |
Cellular Component | Golgi cisterna membrane | |
Cellular Component | Golgi medial cisterna | |
Cellular Component | Golgi membrane | |
Molecular Function | galactosylxylosylprotein 3-beta-galactosyltransferase activity | |
Biological Process | chondroitin sulfate biosynthetic process | |
Biological Process | glycosaminoglycan biosynthetic process | |
Biological Process | heparan sulfate proteoglycan biosynthetic process | |
Biological Process | protein O-linked glycosylation | |
Biological Process | proteoglycan biosynthetic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameBeta-1,3-galactosyltransferase 6
- EC number
- Short namesBeta-1,3-GalTase 6; Beta3Gal-T6; Beta3GalT6
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ91Z92
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-11 | Cytoplasmic | ||||
Sequence: MKVFRRAWRHR | ||||||
Transmembrane | 12-30 | Helical; Signal-anchor for type II membrane protein | ||||
Sequence: VALGLGGLAFCGTTLLYLA | ||||||
Topological domain | 31-325 | Lumenal | ||||
Sequence: RCASEGETPSASGAARPRAKAFLAVLVASAPRAVERRTAVRSTWLAPERRGGPEDVWARFAVGTGGLGSEERRALELEQAQHGDLLLLPALRDAYENLTAKVLAMLTWLDERVDFEFVLKADDDSFARLDAILVDLRAREPARRRRLYWGFFSGRGRVKPGGRWREAAWQLCDYYLPYALGGGYVLSADLVHYLRLSREYLRAWHSEDVSLGTWLAPVDVQREHDPRFDTEYKSRGCNNQYLVTHKQSPEDMLEKQQMLLHEGRLCKHEVQLRLSYVYDWSAPPSQCCQRKEGVP |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000219169 | 1-325 | Beta-1,3-galactosyltransferase 6 | |||
Sequence: MKVFRRAWRHRVALGLGGLAFCGTTLLYLARCASEGETPSASGAARPRAKAFLAVLVASAPRAVERRTAVRSTWLAPERRGGPEDVWARFAVGTGGLGSEERRALELEQAQHGDLLLLPALRDAYENLTAKVLAMLTWLDERVDFEFVLKADDDSFARLDAILVDLRAREPARRRRLYWGFFSGRGRVKPGGRWREAAWQLCDYYLPYALGGGYVLSADLVHYLRLSREYLRAWHSEDVSLGTWLAPVDVQREHDPRFDTEYKSRGCNNQYLVTHKQSPEDMLEKQQMLLHEGRLCKHEVQLRLSYVYDWSAPPSQCCQRKEGVP | ||||||
Glycosylation | 127 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Sequence
- Sequence statusComplete
- Length325
- Mass (Da)37,021
- Last updated2001-12-01 v1
- Checksum971D2C00528169A2
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY050569 EMBL· GenBank· DDBJ | AAL11441.1 EMBL· GenBank· DDBJ | mRNA | ||
AK033608 EMBL· GenBank· DDBJ | BAC28387.1 EMBL· GenBank· DDBJ | mRNA | ||
AK078083 EMBL· GenBank· DDBJ | BAC37119.1 EMBL· GenBank· DDBJ | mRNA | ||
AK090344 EMBL· GenBank· DDBJ | BAC41178.1 EMBL· GenBank· DDBJ | mRNA | ||
BC082998 EMBL· GenBank· DDBJ | AAH82998.1 EMBL· GenBank· DDBJ | mRNA |