Q91YY2 · B4GT3_MOUSE

  • Protein
    Beta-1,4-galactosyltransferase 3
  • Gene
    B4galt3
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Pathway

Protein modification; protein glycosylation.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site132-136UDP-alpha-D-galactose (UniProtKB | ChEBI)
Binding site171-173UDP-alpha-D-galactose (UniProtKB | ChEBI)
Binding site198-199UDP-alpha-D-galactose (UniProtKB | ChEBI)
Binding site199Mn2+ (UniProtKB | ChEBI)
Binding site228UDP-alpha-D-galactose (UniProtKB | ChEBI)
Binding site260UDP-alpha-D-galactose (UniProtKB | ChEBI)
Binding site262-265N-acetyl-D-glucosamine (UniProtKB | ChEBI)
Binding site293Mn2+ (UniProtKB | ChEBI)
Binding site293-295UDP-alpha-D-galactose (UniProtKB | ChEBI)
Binding site305N-acetyl-D-glucosamine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular ComponentGolgi apparatus
Cellular ComponentGolgi cisterna membrane
Molecular Functionbeta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity
Molecular Functiongalactosyltransferase activity
Molecular Functionmetal ion binding
Molecular FunctionN-acetyllactosamine synthase activity
Biological Processcarbohydrate metabolic process
Biological Processgalactosylceramide biosynthetic process
Biological Processglycosylation
Biological Processprotein glycosylation

Keywords

Enzyme and pathway databases

Protein family/group databases

    • GT7Glycosyltransferase Family 7

Names & Taxonomy

Protein names

  • Recommended name
    Beta-1,4-galactosyltransferase 3
  • EC number
  • Short names
    Beta-1,4-GalTase 3; Beta4Gal-T3; b4Gal-T3
  • Alternative names
    • Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase
    • Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase (EC:2.4.1.38
      ) . EC:2.4.1.38 (UniProtKB | ENZYME | Rhea)
    • N-acetyllactosamine synthase (EC:2.4.1.90
      ) . EC:2.4.1.90 (UniProtKB | ENZYME | Rhea)
    • Nal synthase
    • Neolactotriaosylceramide beta-1,4-galactosyltransferase (EC:2.4.1.275) . EC:2.4.1.275 (UniProtKB | ENZYME | Rhea)

Gene names

    • Name
      B4galt3

Organism names

  • Taxonomic identifier
  • Strain
    • FVB/N
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q91YY2
  • Secondary accessions
    • Q9QY13

Proteomes

Organism-specific databases

Subcellular Location

Golgi apparatus, Golgi stack membrane
; Single-pass type II membrane protein
Note: Trans cisternae of Golgi stack.

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-10Cytoplasmic
Transmembrane11-31Helical; Signal-anchor for type II membrane protein
Topological domain32-395Lumenal

Keywords

PTM/Processing

Features

Showing features for chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
ChainPRO_00000805381-395Beta-1,4-galactosyltransferase 3
Glycosylation57N-linked (GlcNAc...) asparagine
Disulfide bond79↔121
Glycosylation168N-linked (GlcNAc...) asparagine
Disulfide bond192↔211
Glycosylation339N-linked (GlcNAc...) asparagine
Glycosylation387N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region340-395Disordered

Sequence similarities

Belongs to the glycosyltransferase 7 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    395
  • Mass (Da)
    44,084
  • Last updated
    2001-12-01 v1
  • Checksum
    16401B033EEB4B21
MLRRLLERPCTLALLVGSQLAVMMYLSLGGFRSLSALFGRDPGPTFDYSHPHDVYSNLSHLPAAPGAAGAPPAQALPYCPERSPFLVGPVSVSFSPVPSLAEIVERNPRVESGGRYRPAGCEPRSRTAIIVPHRAREHHLRLLLYHLHPFLQRQQLAYGIYVIHQAGNGTFNRAKLLNVGVREALRDEEWDCLFLHDVDLLPENDHNLYVCDPRGPRHVAVAMNKFGYSLPYPQYFGGVSALTPDQYLKMNGFPNEYWGWGGEDDDIATRVRLAGMKISRPPTSVGHYKMVKHRGDKGNEENPHRFDLLVRTQNSWTQDGMNSLTYRLLARELGPLYTNITADIGTDPRGPRSPSGPRYPPGSSQAFRQEMLQRRPPARPGPLPTANHTAPRGSH

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A0A6YXE7A0A0A6YXE7_MOUSEB4galt3173
A0A0A6YXS2A0A0A6YXS2_MOUSEB4galt313
D3YUU0D3YUU0_MOUSEB4galt365
D3YVA5D3YVA5_MOUSEB4galt3139

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict353in Ref. 1; AAF22221

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF142671
EMBL· GenBank· DDBJ
AAF22221.1
EMBL· GenBank· DDBJ
mRNA
BC013619
EMBL· GenBank· DDBJ
AAH13619.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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