Q91YE9 · 5NT1B_MOUSE

  • Protein
    Cytosolic 5'-nucleotidase 1B
  • Gene
    Nt5c1b
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Catalyzes the hydrolysis of nucleotide monophosphates, releasing inorganic phosphate and the corresponding nucleoside, AMP is the major substrate.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Activity regulation

Activated by ADP.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site428Nucleophile

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Function5'-nucleotidase activity
Molecular Functionmagnesium ion binding
Molecular Functionnucleotide binding
Molecular FunctionXMP 5'-nucleosidase activity
Biological Processadenosine metabolic process
Biological Processallantoin metabolic process
Biological Processamide catabolic process
Biological ProcessAMP catabolic process
Biological Processnucleoside metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytosolic 5'-nucleotidase 1B
  • EC number
  • Short names
    cN1B
  • Alternative names
    • Autoimmune infertility-related protein
    • Cytosolic 5'-nucleotidase IB (cN-IB)

Gene names

    • Name
      Nt5c1b
    • Synonyms
      Airp

Organism names

  • Taxonomic identifier
  • Strains
    • CD-1
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q91YE9
  • Secondary accessions
    • E9QNH2
    • Q91Y48

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001447971-573Cytosolic 5'-nucleotidase 1B

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed at highest levels in testis. Also expressed in brain, skeletal muscle, kidney and heart.

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for compositional bias, region.

TypeIDPosition(s)Description
Compositional bias1-35Basic and acidic residues
Region1-200Disordered
Compositional bias36-78Polar residues
Compositional bias86-133Polar residues
Compositional bias160-178Basic and acidic residues
Region218-238Disordered

Sequence similarities

Belongs to the 5'-nucleotidase type 3 family.

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q91YE9-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    573
  • Mass (Da)
    65,002
  • Last updated
    2011-06-28 v2
  • Checksum
    948868F505D6B965
MSQTSLKHKKKNEPGMRYSKESLDAEKRKDSDKTGARLSTQGSQELPLHNTDSRGYVVRNQWSRTSRSPSTGAPSVDEPRSRNTAIKVEAPNSSTTSRTSSASPSQHETSPPPQTSEKSSIQQTPQNRPITQLESQPPTPPETEPNSRRTSAKMYTGSDPWAHRENREPRDLQLRDYAYSCDSREGMPKTREYPRTPPTEWKPYAQRRLQYGTSVDMEPEYISDGPQQRQRQQTEEDEVDEAYWTSVSMLYEKIPSCARPRPPKPKHAITIAVSSRALFNMVDDRKIYEEEGLEKYMEYQLTNENVILTPGPAFRFVKALQHVNSRLRDLYPDEQDLFDIVLMTNNHAQVGVRLINSVNHYGLLIDRFCLTGGKSPIGYLKAYLTNLYLSADSEKVQEAIKEGIASATMYAGAKDMAYCDTQLRVAFDGDAVLFSDESEHIAKDHGLDKFFQHETLFENKPLAQGPLKSFLEDLGKLQKKFYAKDERLLCPIRTYLVTARSAASSGARVLKTLRRWGLEIDEALFLAGAPKGPILVKIRPHIFFDDQMFHIESAQKFGTITAHVPYGIAQKRN

Q91YE9-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 17 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1Y7VK90A0A1Y7VK90_MOUSENt5c1b557
A0A1Y7VJB2A0A1Y7VJB2_MOUSENt5c1b452
A0A1W2P6J4A0A1W2P6J4_MOUSENt5c1b302
A0A1W2P7E9A0A1W2P7E9_MOUSENt5c1b571
A0A1W2P7K9A0A1W2P7K9_MOUSENt5c1b615
A0A1W2P7D6A0A1W2P7D6_MOUSENt5c1b382
A0A1W2P782A0A1W2P782_MOUSENt5c1b430
A0A1W2P6X8A0A1W2P6X8_MOUSENt5c1b631
A0A1W2P6R5A0A1W2P6R5_MOUSENt5c1b320
A0A1W2P710A0A1W2P710_MOUSENt5c1b362
A0A1W2P7V4A0A1W2P7V4_MOUSENt5c1b391
A0A1W2P893A0A1W2P893_MOUSENt5c1b378
A0A1W2P7P9A0A1W2P7P9_MOUSENt5c1b280
A0A1W2P7Q8A0A1W2P7Q8_MOUSENt5c1b269
A0A1W2P7S7A0A1W2P7S7_MOUSENt5c1b495
D3Z145D3Z145_MOUSENt5c1b271
D6REF4D6REF4_MOUSENt5c1b474

Sequence caution

The sequence AAK39109.1 differs from that shown. Reason: Erroneous initiation

Features

Showing features for compositional bias, alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Compositional bias1-35Basic and acidic residues
Compositional bias36-78Polar residues
Compositional bias86-133Polar residues
Alternative sequenceVSP_01020488-89in isoform 2
Sequence conflict103in Ref. 2; AAK39109
Sequence conflict121in Ref. 1; CAC44364 and 2; AAK39109
Compositional bias160-178Basic and acidic residues
Sequence conflict162in Ref. 1; CAC44364
Sequence conflict185in Ref. 1; CAC44364
Sequence conflict228in Ref. 1; CAC44364
Alternative sequenceVSP_010205247-262in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ295253
EMBL· GenBank· DDBJ
CAC44364.1
EMBL· GenBank· DDBJ
mRNA
AF356186
EMBL· GenBank· DDBJ
AAK39109.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AC157570
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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