Q91YE9 · 5NT1B_MOUSE
- ProteinCytosolic 5'-nucleotidase 1B
- GeneNt5c1b
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids573 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Catalyzes the hydrolysis of nucleotide monophosphates, releasing inorganic phosphate and the corresponding nucleoside, AMP is the major substrate.
Catalytic activity
- a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate
- AMP + H2O = adenosine + phosphate
Cofactor
Activity regulation
Activated by ADP.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 428 | Nucleophile | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | 5'-nucleotidase activity | |
Molecular Function | magnesium ion binding | |
Molecular Function | nucleotide binding | |
Molecular Function | XMP 5'-nucleosidase activity | |
Biological Process | adenosine metabolic process | |
Biological Process | allantoin metabolic process | |
Biological Process | amide catabolic process | |
Biological Process | AMP catabolic process | |
Biological Process | nucleoside metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytosolic 5'-nucleotidase 1B
- EC number
- Short namescN1B
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ91YE9
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000144797 | 1-573 | Cytosolic 5'-nucleotidase 1B | |||
Sequence: MSQTSLKHKKKNEPGMRYSKESLDAEKRKDSDKTGARLSTQGSQELPLHNTDSRGYVVRNQWSRTSRSPSTGAPSVDEPRSRNTAIKVEAPNSSTTSRTSSASPSQHETSPPPQTSEKSSIQQTPQNRPITQLESQPPTPPETEPNSRRTSAKMYTGSDPWAHRENREPRDLQLRDYAYSCDSREGMPKTREYPRTPPTEWKPYAQRRLQYGTSVDMEPEYISDGPQQRQRQQTEEDEVDEAYWTSVSMLYEKIPSCARPRPPKPKHAITIAVSSRALFNMVDDRKIYEEEGLEKYMEYQLTNENVILTPGPAFRFVKALQHVNSRLRDLYPDEQDLFDIVLMTNNHAQVGVRLINSVNHYGLLIDRFCLTGGKSPIGYLKAYLTNLYLSADSEKVQEAIKEGIASATMYAGAKDMAYCDTQLRVAFDGDAVLFSDESEHIAKDHGLDKFFQHETLFENKPLAQGPLKSFLEDLGKLQKKFYAKDERLLCPIRTYLVTARSAASSGARVLKTLRRWGLEIDEALFLAGAPKGPILVKIRPHIFFDDQMFHIESAQKFGTITAHVPYGIAQKRN |
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed at highest levels in testis. Also expressed in brain, skeletal muscle, kidney and heart.
Gene expression databases
Structure
Family & Domains
Features
Showing features for compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-35 | Basic and acidic residues | ||||
Sequence: MSQTSLKHKKKNEPGMRYSKESLDAEKRKDSDKTG | ||||||
Region | 1-200 | Disordered | ||||
Sequence: MSQTSLKHKKKNEPGMRYSKESLDAEKRKDSDKTGARLSTQGSQELPLHNTDSRGYVVRNQWSRTSRSPSTGAPSVDEPRSRNTAIKVEAPNSSTTSRTSSASPSQHETSPPPQTSEKSSIQQTPQNRPITQLESQPPTPPETEPNSRRTSAKMYTGSDPWAHRENREPRDLQLRDYAYSCDSREGMPKTREYPRTPPTE | ||||||
Compositional bias | 36-78 | Polar residues | ||||
Sequence: ARLSTQGSQELPLHNTDSRGYVVRNQWSRTSRSPSTGAPSVDE | ||||||
Compositional bias | 86-133 | Polar residues | ||||
Sequence: IKVEAPNSSTTSRTSSASPSQHETSPPPQTSEKSSIQQTPQNRPITQL | ||||||
Compositional bias | 160-178 | Basic and acidic residues | ||||
Sequence: PWAHRENREPRDLQLRDYA | ||||||
Region | 218-238 | Disordered | ||||
Sequence: EPEYISDGPQQRQRQQTEEDE |
Sequence similarities
Belongs to the 5'-nucleotidase type 3 family.
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q91YE9-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length573
- Mass (Da)65,002
- Last updated2011-06-28 v2
- Checksum948868F505D6B965
Q91YE9-2
- Name2
Computationally mapped potential isoform sequences
There are 17 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A1Y7VK90 | A0A1Y7VK90_MOUSE | Nt5c1b | 557 | ||
A0A1Y7VJB2 | A0A1Y7VJB2_MOUSE | Nt5c1b | 452 | ||
A0A1W2P6J4 | A0A1W2P6J4_MOUSE | Nt5c1b | 302 | ||
A0A1W2P7E9 | A0A1W2P7E9_MOUSE | Nt5c1b | 571 | ||
A0A1W2P7K9 | A0A1W2P7K9_MOUSE | Nt5c1b | 615 | ||
A0A1W2P7D6 | A0A1W2P7D6_MOUSE | Nt5c1b | 382 | ||
A0A1W2P782 | A0A1W2P782_MOUSE | Nt5c1b | 430 | ||
A0A1W2P6X8 | A0A1W2P6X8_MOUSE | Nt5c1b | 631 | ||
A0A1W2P6R5 | A0A1W2P6R5_MOUSE | Nt5c1b | 320 | ||
A0A1W2P710 | A0A1W2P710_MOUSE | Nt5c1b | 362 | ||
A0A1W2P7V4 | A0A1W2P7V4_MOUSE | Nt5c1b | 391 | ||
A0A1W2P893 | A0A1W2P893_MOUSE | Nt5c1b | 378 | ||
A0A1W2P7P9 | A0A1W2P7P9_MOUSE | Nt5c1b | 280 | ||
A0A1W2P7Q8 | A0A1W2P7Q8_MOUSE | Nt5c1b | 269 | ||
A0A1W2P7S7 | A0A1W2P7S7_MOUSE | Nt5c1b | 495 | ||
D3Z145 | D3Z145_MOUSE | Nt5c1b | 271 | ||
D6REF4 | D6REF4_MOUSE | Nt5c1b | 474 |
Sequence caution
Features
Showing features for compositional bias, alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-35 | Basic and acidic residues | ||||
Sequence: MSQTSLKHKKKNEPGMRYSKESLDAEKRKDSDKTG | ||||||
Compositional bias | 36-78 | Polar residues | ||||
Sequence: ARLSTQGSQELPLHNTDSRGYVVRNQWSRTSRSPSTGAPSVDE | ||||||
Compositional bias | 86-133 | Polar residues | ||||
Sequence: IKVEAPNSSTTSRTSSASPSQHETSPPPQTSEKSSIQQTPQNRPITQL | ||||||
Alternative sequence | VSP_010204 | 88-89 | in isoform 2 | |||
Sequence: Missing | ||||||
Sequence conflict | 103 | in Ref. 2; AAK39109 | ||||
Sequence: S → F | ||||||
Sequence conflict | 121 | in Ref. 1; CAC44364 and 2; AAK39109 | ||||
Sequence: I → T | ||||||
Compositional bias | 160-178 | Basic and acidic residues | ||||
Sequence: PWAHRENREPRDLQLRDYA | ||||||
Sequence conflict | 162 | in Ref. 1; CAC44364 | ||||
Sequence: A → V | ||||||
Sequence conflict | 185 | in Ref. 1; CAC44364 | ||||
Sequence: E → Q | ||||||
Sequence conflict | 228 | in Ref. 1; CAC44364 | ||||
Sequence: Q → H | ||||||
Alternative sequence | VSP_010205 | 247-262 | in isoform 2 | |||
Sequence: Missing |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJ295253 EMBL· GenBank· DDBJ | CAC44364.1 EMBL· GenBank· DDBJ | mRNA | ||
AF356186 EMBL· GenBank· DDBJ | AAK39109.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AC157570 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |