Lineage-specific biology revealed by a finished genome assembly of the mouse.Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L.[...], Ponting C.P.View abstractCited forNUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]StrainC57BL/6JCategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCPLoS Biol. 7:E1000112-E1000112 (2009)Cited in99+99+
Characterization and comparative analysis of the EGLN gene family.Taylor M.S.View abstractCited forNUCLEOTIDE SEQUENCE [MRNA] OF 34-400CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCGene 275:125-132 (2001)Cited in6Mapped to8
Mammalian EGLN genes have distinct patterns of mRNA expression and regulation.Lieb M.E., Menzies K., Moschella M.C., Ni R., Taubman M.B.View abstractCited forNUCLEOTIDE SEQUENCE [MRNA] OF 205-400, TISSUE SPECIFICITYCategoriesSequences, ExpressionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCBiochem. Cell Biol. 80:421-426 (2002)Cited in3
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).The MGC Project TeamView abstractCited forNUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 268-400TissueMammary glandCategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCGenome Res. 14:2121-2127 (2004)Cited in99+99+
SM-20 is a novel growth factor-responsive gene regulated during skeletal muscle development and differentiation.Moschella M.C., Menzies K., Tsao L., Lieb M.A., Kohtz J.D., Kohtz D.S., Taubman M.B.View abstractCited forINDUCTIONCategoriesExpressionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCGene Expr. 8:59-66 (1999)Cited in2Mapped to2
Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure.Minamishima Y.A., Moslehi J., Bardeesy N., Cullen D., Bronson R.T., Kaelin W.G. Jr.View abstractCited forDISRUPTION PHENOTYPE, FUNCTIONCategoriesFunction, Phenotypes & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCBlood 111:3236-3244 (2008)Cited in1Mapped to4
Enhancement of angiogenesis through stabilization of hypoxia-inducible factor-1 by silencing prolyl hydroxylase domain-2 gene.Wu S., Nishiyama N., Kano M.R., Morishita Y., Miyazono K., Itaka K., Chung U.I., Kataoka K.View abstractCited forDISRUPTION PHENOTYPE, FUNCTIONCategoriesFunction, Phenotypes & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCMol. Ther. 16:1227-1234 (2008)Cited in1Mapped to1
A tissue-specific atlas of mouse protein phosphorylation and expression.Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.View abstractCited forIDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]TissueBrown adipose tissue, Heart, Lung, TestisCategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCCell 143:1174-1189 (2010)Cited in99+99+Mapped to6
Prolyl hydroxylase domain protein 2 (PHD2) mediates oxygen-induced retinopathy in neonatal mice.Duan L.J., Takeda K., Fong G.H.View abstractCited forDISRUPTION PHENOTYPE, FUNCTIONCategoriesFunction, Phenotypes & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCAm. J. Pathol. 178:1881-1890 (2011)Cited in1Mapped to1
CRISPR editing of anti-anemia drug target rescues independent preclinical models of retinitis pigmentosa.Nolan N.D., Cui X., Robbings B.M., Demirkol A., Pandey K., Wu W.H., Hu H.F., Jenny L.A., Lin C.S.[...], Tsang S.H.View abstractSourceMGI: 1932286PubMedEurope PMCCell Rep Med 5:101459-101459 (2024)Mapped to23
Endothelial specific prolyl hydroxylase domain-containing protein 2 deficiency attenuates aging-related obesity and exercise intolerance.Pan L., He X., Xu R., Bhattarai U., Niu Z., do Carmo J., Sun Y., Zeng H., Clemmer J.S.[...], Chen Y.View abstractAnnotationEndothelial specific prolyl hydroxylase domain-containing protein 2 deficiency attenuates aging-related obesity and exercise intolerance.SourceGeneRif: 112405PubMedEurope PMCGeroscience 46:3945-3956 (2024)Mapped to2
Loss of prolyl hydroxylase 1 and 2 in SM22alpha-expressing cells prevents Hypoxia-Induced pulmonary hypertension.Barnes E.A., Ito R., Che X., Alvira C.M., Cornfield D.N.View abstractAnnotationLoss of prolyl hydroxylase 1 and 2 in SM22alpha-expressing cells prevents Hypoxia-Induced pulmonary hypertension.CategoriesFunctionSourceGeneRif: 112405, MGI: 1932286PubMedEurope PMCAm J Physiol Lung Cell Mol Physiol 325:L741-L755 (2023)Mapped to20
Prolonged hypoxia alleviates prolyl hydroxylation-mediated suppression of RIPK1 to promote necroptosis and inflammation.Zhang T., Xu D., Liu J., Wang M., Duan L.J., Liu M., Meng H., Zhuang Y., Wang H.[...], Wei W.View abstractCategoriesFunctionSourceMGI: 1932286PubMedEurope PMCNat Cell Biol 25:950-962 (2023)Mapped to27
Proline hydroxylase 2 (PHD2) promotes brown adipose thermogenesis by enhancing the hydroxylation of UCP1.Li F., Zhang F., Yi X., Quan L.L., Yang X., Yin C., Ma Z., Wu R., Zhao W.[...], Wang S.View abstractAnnotationProline hydroxylase 2 (PHD2) promotes brown adipose thermogenesis by enhancing the hydroxylation of UCP1.CategoriesFunction, ExpressionSourceGeneRif: 112405PubMedEurope PMCMol Metab 73:101747-101747 (2023)Mapped to3
HIF prolyl hydroxylase 2/3 deletion disrupts astrocytic integrity and exacerbates neuroinflammation.Rosiewicz K.S., Muinjonov B., Kunz S., Radbruch H., Chen J., Juttner R., Kerkering J., Ucar J., Crowley T.[...], Siffrin V.View abstractCategoriesFunctionSourceMGI: 1932286PubMedEurope PMCGlia 71:2024-2044 (2023)Mapped to4
Tailless and hypoxia inducible factor-2alpha cooperate to sustain proangiogenic states of retinal astrocytes in neonatal mice.Duan L.J., Jiang Y., Shi Y., Fong G.H.View abstractCategoriesFunctionSourceMGI: 1932286PubMedEurope PMCBiol Open 12:bio059684-bio059684 (2023)Mapped to7
The HIF-prolyl hydroxylases have distinct and nonredundant roles in colitis-associated cancer.Kennel K.B., Burmeister J., Radhakrishnan P., Giese N.A., Giese T., Salfenmoser M., Gebhardt J.M., Strowitzki M.J., Taylor C.T.[...], Harnoss J.M.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1932286PubMedEurope PMCJCI Insight 7:e153337-e153337 (2022)Mapped to8
HIF1 inhibitor acriflavine rescues early-onset preeclampsia phenotype in mice lacking placental prolyl hydroxylase domain protein 2.Sallais J., Park C., Alahari S., Porter T., Liu R., Kurt M., Farrell A., Post M., Caniggia I.View abstractCategoriesFunctionSourceMGI: 1932286PubMedEurope PMCJCI Insight 7:e158908-e158908 (2022)Mapped to78
Adipocyte-derived lactate is a signalling metabolite that potentiates adipose macrophage inflammation via targeting PHD2.Feng T., Zhao X., Gu P., Yang W., Wang C., Guo Q., Long Q., Liu Q., Cheng Y.[...], Hui X.View abstractAnnotationAdipocyte-derived lactate is a signalling metabolite that potentiates adipose macrophage inflammation via targeting PHD2.CategoriesFunctionSourceGeneRif: 112405, MGI: 1932286PubMedEurope PMCNat Commun 13:5208-5208 (2022)Mapped to38
Myeloid PHD2 deficiency accelerates neointima formation via Hif-1alpha.Christoph M., Pfluecke C., Mensch M., Augstein A., Jellinghaus S., Ende G., Mierke J., Franke K., Wielockx B.[...], Poitz D.M.View abstractAnnotationMyeloid PHD2 deficiency accelerates neointima formation via Hif-1alpha.CategoriesFunction, Phenotypes & VariantsSourceGeneRif: 112405, MGI: 1932286PubMedEurope PMCMol Immunol 149:48-58 (2022)Mapped to11
AMP-activated protein kinase alpha1 phosphorylates PHD2 to maintain systemic iron homeostasis.Wang C., Zhang W., Xu W., Liu Z., Huang K.View abstractAnnotationAMP-activated protein kinase alpha1 phosphorylates PHD2 to maintain systemic iron homeostasis.CategoriesFunction, PTM / ProcessingSourceGeneRif: 112405PubMedEurope PMCClin Transl Med 12:e854-e854 (2022)Mapped to17
Deletion of hypoxia-inducible factor prolyl 4-hydroxylase 2 in FoxD1- lineage mesenchymal cells leads to congenital truncal alopecia.Rosendahl A.H., Monnius M., Laitala A., Railo A., Miinalainen I., Heljasvaara R., Maki J.M., Myllyharju J.View abstractAnnotationDeletion of hypoxia-inducible factor prolyl 4-hydroxylase 2 in FoxD1-lineage mesenchymal cells leads to congenital truncal alopecia.CategoriesFunction, ExpressionSourceGeneRif: 112405, MGI: 1932286PubMedEurope PMCJ Biol Chem 298:101787-101787 (2022)Mapped to99+
Adaptation of the Oxygen Sensing System during Lung Development.Kirschner K.M., Kelterborn S., Stehr H., Penzlin J.L.T., Jacobi C.L.J., Endesfelder S., Sieg M., Kruppa J., Dame C., Sciesielski L.K.View abstractCategoriesExpressionSourceMGI: 1932286PubMedEurope PMCOxid Med Cell Longev 2022:9714669-9714669 (2022)Mapped to49
The oxygen sensor prolyl hydroxylase domain 2 regulates the in vivo suppressive capacity of regulatory T cells.Ajouaou Y., Azouz A., Taquin A., Denanglaire S., Hussein H., Krayem M., Andris F., Moser M., Goriely S., Leo O.View abstractAnnotationThe oxygen sensor prolyl hydroxylase domain 2 regulates the in vivo suppressive capacity of regulatory T cells.CategoriesFunctionSourceGeneRif: 112405, MGI: 1932286PubMedEurope PMCElife 11:e70555-e70555 (2022)Mapped to16
Repression of hypoxia-inducible factor-1 contributes to increased mitochondrial reactive oxygen species production in diabetes.Zheng X., Narayanan S., Xu C., Eliasson Angelstig S., Grunler J., Zhao A., Di Toro A., Bernardi L., Mazzone M.[...], Catrina S.B.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1932286PubMedEurope PMCElife 11:e70714-e70714 (2022)Mapped to13