Q91YD3 · DCP1A_MOUSE
- ProteinmRNA-decapping enzyme 1A
- GeneDcp1a
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids602 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1 (By similarity).
Essential for embryonic development (PubMed:11836524).
Essential for embryonic development (PubMed:11836524).
Catalytic activity
- a 5'-end (N7-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + 2 H+ + N7-methyl-GDPThis reaction proceeds in the forward direction.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | dendrite | |
Cellular Component | nucleus | |
Cellular Component | P-body | |
Cellular Component | transcription regulator complex | |
Molecular Function | 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity | |
Molecular Function | enzyme activator activity | |
Molecular Function | identical protein binding | |
Molecular Function | kinesin binding | |
Molecular Function | mRNA binding | |
Biological Process | deadenylation-dependent decapping of nuclear-transcribed mRNA | |
Biological Process | deadenylation-independent decapping of nuclear-transcribed mRNA | |
Biological Process | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | |
Biological Process | positive regulation of DNA-templated transcription | |
Biological Process | protein localization to cytoplasmic stress granule | |
Biological Process | transforming growth factor beta receptor signaling pathway |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namemRNA-decapping enzyme 1A
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ91YD3
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Predominantly cytoplasmic, in processing bodies (PB). Nuclear, after TGFB1 treatment. Translocation to the nucleus depends on interaction with SMAD4 (By similarity).
Colocalizes with NANOS3 in the processing bodies (PubMed:19861488).
Colocalizes with NANOS3 in the processing bodies (PubMed:19861488).
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Embryonic lethality around embryonic day 10.5 concomitant with massive growth retardation and cardiac developmental defects seen.
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | 481 | in strain: C57BL/6J | ||||
Sequence: Q → R |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 25 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000189633 | 1-602 | mRNA-decapping enzyme 1A | |||
Sequence: MALSCSTVRPRRRGSALRSKMELLSRAEQEMSLAALKQHDPYITSIADLTGQVALYTFCPKANQWEKTDIEGTLFVYRRSASPYHGFTIVNRLNMHNLVEPVNKDLEFQLHEPFLLYRNASLSIYSIWFYDKNDCHRIAKLMADVVEEETRRSQQAARDKQSPSQANGCSDQRPIDILEMLSRAKDEYERNQMGGSNISSPGLQPSTQLSNLGSTETLEETPSGSQDKSAPSGHKHLTVEELFGTSLPKEQPTAMGLESEDTDKLLGDASQKEPSSFLPFPFEQSGGAPQSENLGIHSAAHHTVQPEVSTPVLITPASIAQSGDKHPPSYTLPLSPVLSPTLPAEAPTTQVPHLPRNSTMIQAVKTTPRQKSPLLNQPVPELSHSSLVASQSPFRAPVSLANPAGTALPSVDLLQKLRLTPQHDQIQAQPLGKGTMAPSFSSAAGQLATPESFIEPSSKTAAARAAVSASLSNMVLAPTLQSMQQNQDPEVFSQPKVLPSAIPIAGSPLVPATTTAVSSVLLSPSVFQQTVPRAADLERKASSPSPLTVGTAESQRKPSIILSKSQLQDTLIHLIKNDSSFLSTLHAVYLQVLTKNKDNHNL | ||||||
Modified residue | 82 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 162 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 199 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 200 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 335 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 339 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 367 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 372 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 395 | Asymmetric dimethylarginine | ||||
Sequence: R | ||||||
Modified residue | 420 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 441 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 542 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 543 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 545 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 548 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 551 | Phosphothreonine | ||||
Sequence: T |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Ubiquitous, with highest expression in the spleen and testis (at protein level).
Developmental stage
Expression detectable at 9.5 dpc and progressively increases from 11.5 dpc onwards (at protein level).
Gene expression databases
Interaction
Subunit
Forms a complex with EDC3, DCP2, DDX6 and EDC4/HEDLS, within this complex directly interacts with EDC3. Part of a cytoplasmic complex containing proteins involved in mRNA decay, including XRN1 and LSM1. Interacts with DCP1B. Interacts with DCP2. Interacts with DDX17 in an RNA-independent manner. Interacts with PNRC2. Interacts with SMAD4. Interacts with UPF1. Interacts with ZC3HAV1. Interacts with ZFP36L1. Interacts with NBDY. Interacts with DHX34; the interaction is RNA-independent (By similarity).
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 152-174 | Disordered | ||||
Sequence: RSQQAARDKQSPSQANGCSDQRP | ||||||
Compositional bias | 157-171 | Polar residues | ||||
Sequence: ARDKQSPSQANGCSD | ||||||
Region | 191-234 | Disordered | ||||
Sequence: NQMGGSNISSPGLQPSTQLSNLGSTETLEETPSGSQDKSAPSGH | ||||||
Compositional bias | 192-232 | Polar residues | ||||
Sequence: QMGGSNISSPGLQPSTQLSNLGSTETLEETPSGSQDKSAPS | ||||||
Region | 267-291 | Disordered | ||||
Sequence: GDASQKEPSSFLPFPFEQSGGAPQS |
Sequence similarities
Belongs to the DCP1 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length602
- Mass (Da)65,219
- Last updated2001-12-01 v1
- Checksum55BC9C32BCA86CFD
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A286YCN4 | A0A286YCN4_MOUSE | Dcp1a | 177 | ||
A0A286YDC8 | A0A286YDC8_MOUSE | Dcp1a | 419 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 157-171 | Polar residues | ||||
Sequence: ARDKQSPSQANGCSD | ||||||
Compositional bias | 192-232 | Polar residues | ||||
Sequence: QMGGSNISSPGLQPSTQLSNLGSTETLEETPSGSQDKSAPS |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJ344447 EMBL· GenBank· DDBJ | CAC69875.1 EMBL· GenBank· DDBJ | mRNA | ||
BC066173 EMBL· GenBank· DDBJ | AAH66173.1 EMBL· GenBank· DDBJ | mRNA |