Q91XV4 · DCXR_MESAU
- ProteinL-xylulose reductase
- GeneDCXR
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids244 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules.
Catalytic activity
- xylitol + NADP+ = L-xylulose + NADPH + H+
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 11-39 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 136 | substrate | |||
Active site | 149 | Proton acceptor | |||
Active site | 153 | ||||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | acrosomal vesicle | |
Cellular Component | brush border | |
Cellular Component | cytoplasmic microtubule | |
Cellular Component | cytosol | |
Cellular Component | membrane | |
Cellular Component | microvillus | |
Molecular Function | carbonyl reductase (NADPH) activity | |
Molecular Function | identical protein binding | |
Molecular Function | L-xylulose reductase (NADPH) activity | |
Molecular Function | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | |
Biological Process | D-glucuronate catabolic process to D-xylulose 5-phosphate | |
Biological Process | D-xylose metabolic process | |
Biological Process | glucose metabolic process | |
Biological Process | NADP metabolic process | |
Biological Process | positive regulation of reactive oxygen species metabolic process | |
Biological Process | xylulose metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameL-xylulose reductase
- EC number
- Short namesXR
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Cricetidae > Cricetinae > Mesocricetus
Accessions
- Primary accessionQ91XV4
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Peripheral membrane protein
Note: Probably recruited to membranes via an interaction with phosphatidylinositol. During epididymal transit, it accumulates on the acrosomal cap of spermatozoa.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for modified residue, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Modified residue | 1 | N-acetylmethionine | |||
Chain | PRO_0000054555 | 1-244 | L-xylulose reductase | ||
Modified residue | 21 | Omega-N-methylarginine | |||
Modified residue | 46 | Phosphoserine | |||
Keywords
- PTM
Expression
Tissue specificity
Highly expressed in kidney and liver. Expressed in epididymis. Weakly expressed in brain, heart, lung, spleen and testis.
Interaction
Structure
Sequence
- Sequence statusComplete
- Length244
- Mass (Da)25,675
- Last updated2001-12-01 v1
- MD5 Checksum7531955C0567CD0850961952A928861E
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB045204 EMBL· GenBank· DDBJ | BAB61727.1 EMBL· GenBank· DDBJ | mRNA |