Q91XV4 · DCXR_MESAU

Function

function

Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules.

Catalytic activity

Features

Showing features for binding site, active site.

124420406080100120140160180200220240
Type
IDPosition(s)Description
Binding site11-39NADP+ (UniProtKB | ChEBI)
Binding site136substrate
Active site149Proton acceptor
Active site153

GO annotations

AspectTerm
Cellular Componentacrosomal vesicle
Cellular Componentbrush border
Cellular Componentcytoplasmic microtubule
Cellular Componentcytosol
Cellular Componentmembrane
Cellular Componentmicrovillus
Molecular Functioncarbonyl reductase (NADPH) activity
Molecular Functionidentical protein binding
Molecular FunctionL-xylulose reductase (NADPH) activity
Molecular Functionoxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
Biological ProcessD-glucuronate catabolic process to D-xylulose 5-phosphate
Biological ProcessD-xylose metabolic process
Biological Processglucose metabolic process
Biological ProcessNADP metabolic process
Biological Processpositive regulation of reactive oxygen species metabolic process
Biological Processxylulose metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    L-xylulose reductase
  • EC number
  • Short names
    XR
  • Alternative names
    • Dicarbonyl/L-xylulose reductase
    • Sperm antigen P26h

Gene names

    • Name
      DCXR

Organism names

  • Taxonomic identifier
  • Strain
    • Syrian
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Cricetidae > Cricetinae > Mesocricetus

Accessions

  • Primary accession
    Q91XV4

Proteomes

Subcellular Location

Membrane
; Peripheral membrane protein
Note: Probably recruited to membranes via an interaction with phosphatidylinositol. During epididymal transit, it accumulates on the acrosomal cap of spermatozoa.

Keywords

PTM/Processing

Features

Showing features for modified residue, chain.

Type
IDPosition(s)Description
Modified residue1N-acetylmethionine
ChainPRO_00000545551-244L-xylulose reductase
Modified residue21Omega-N-methylarginine
Modified residue46Phosphoserine

Keywords

Expression

Tissue specificity

Highly expressed in kidney and liver. Expressed in epididymis. Weakly expressed in brain, heart, lung, spleen and testis.

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    244
  • Mass (Da)
    25,675
  • Last updated
    2001-12-01 v1
  • MD5 Checksum
    7531955C0567CD0850961952A928861E
MDLGLAGRRALVTGAGKGIGRSTVLALQAAGAHVVAVSRTQADLDSLVSECPGVETVCVDLADWEATEQALSSVGPVDLLVNNAAVALLQPFLEVTKEAFDMSFNVNLRAVIQVSQIVARGMIARGAPGAIVNVSSQASQRALANHSVYCSTKGALDMLTKMMALELGPHKIRVNAVNPTVVMTSMGRTNWSDPHKAKVMLDRIPLGKFAEVENVVDAILFLLSHRSNMTTGSTLPVDGGFLVT

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB045204
EMBL· GenBank· DDBJ
BAB61727.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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